![](img/space.gif) |
Generation of a genetically engineered total PPARg null mouse line, a new model to study the function of the receptor
|
Help
Print
|
Here you can view and search the projects funded by NKFI since 2004
Back »![](img/space.gif)
![](img/space.gif)
![](img/space.gif)
![](img/space.gif)
|
![](img/print_ver.gif) |
List of publications |
|
|
Czimmerer Z, Varga T, Kiss M, Ovando Vázquez C, Doan-Xuan QM, Rückerl D, Tattikota SG, Yan X, S Nagy Z, Daniel B, Poliska S, Horvath A, Nagy G, Varallyay E, Poy MN, Allen JA, Bacso Z, Abreu-Goodger C, Nagy L: The IL4-STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p, GENOME MED 8: (1) 63, 2016 | Simandi Z, Horvath A, Nagy G P, Nagy L: Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation, JOVE-J VIS EXP : Paper e53978. - közlésre elfogadva, 2016 | Tamas Varga, Rémi Mounier, Attila Horváth, Sylvain Cuvellier, Florent Dumont, Szilárd Póliska, Hamida Ardjoune, Gaëtan Juban, László Nagy, Bénédicte Chazaud: Highly dynamic transcriptional signature of distinct macrophage subsets during sterile inflammation, resolution, and tissue repair, J IMMUNOL *: (*), 2016 | Ixchelt Cuaranta-Monroy, Zoltan Simandi, Laszlo Nagy: Differentiation of Adipocytes in Monolayer from Mouse Embryonic Stem Cells, METHODS MOL BIOL 1341: 407-415, 2015 | Simándi Zoltán, Czipa Erik, Horváth Attila, Kőszeghy Áron, Bordás Csilla, Póliska Szilárd, Juhász István, Imre László, Szabó Gábor, Dezső Balázs, Barta Endre, Sauer Sascha, Károlyi Katalin, Kovács Ilona, Hutóczky Gábor, Bognár László, Klekner Álmos, Szűcs Péter, Bálint Bálint László, Nagy László: PRMT1 and PRMT8 regulate retinoic acid-dependent neuronal differentiation with implications to neuropathology, STEM CELLS 33: (3) 726-741, 2015 | Brazda P, Krieger J, Daniel B, Jonas D, Szekeres T, Langowski J, Tóth K, Nagy L, Vámosi G: Ligand binding shifts highly mobile RXR to chromatin-bound state in a coactivator-dependent manner as revealed by single cell imaging., MOL CELL BIOL 34: (7) 1234-1245, 2014 | Daniel B, Nagy G, Hah H, Horvath A, Czimmerer Z, Poliska P, Gyuris T, Keirsse J, Gysemans C, Ginderachter J, Balint B L, Evans R M, Barta E, Nagy L: The Active Enhancer Network Operated by Liganded RXR Supports Angiogenic Activity in Macrophages, GENE DEV 28: (14) 1562-1577, 2014 | Dozsa A, Dezso B, Toth BI, Bacsi A, Poliska S, Camera E, Picardo M, Zouboulis CC, Biro T, Schmitz G, Liebisch G, Ruhl R, Remenyik E, Nagy L: PPARgamma-Mediated and Arachidonic Acid-Dependent Signaling is Involved in Differentiation and Lipid Production of Human Sebocytes., J INVEST DERMATOL 134: (4) 910-920, 2014 | Kotlinowski J, Grochot-Przeczek A, Taha H, Kozakowska M, Pilecki B, Skrzypek K, Bartelik A, Derlacz R, Horrevoets A J G, Pap A, Nagy L, Dulak J, Jozkowicz A: PPARγ activation but not PPARγ haplodeficiency affects proangiogenic potential of endothelial cells and bone marrow-derived progenitors, CARDIOVASC DIABETOL 13: 150, 2014 | Brignull LM, Czimmerer Z, Saidi H, Daniel B, Villela I, Bartlett NW, Johnston SL, Meira LB, Nagy L, Nohturfft A: Reprogramming of lysosomal gene expression by interleukin-4 and Stat6., BMC GENOMICS 14:, 2013 | Gyongyosi A, Szatmari I, Pap A, Dezso B, Pos Z, Szeles L, Varga T, Nagy L: RDH10, RALDH2 and CRABP2 are required components of PPARg-directed all-trans-retinoic acid synthesis and signaling in human dendritic cells, J LIPID RES 54: (9) 2458-2474, 2013 | Mesko B, Poliska S, Váncsa A, Szekanecz Z, Palatka K, Hollo Z, Horvath A, Steiner L, Zahuczky G, Podani J, Nagy L: Peripheral blood derived gene panels predict response to infliximab in rheumatoid arthritis and Crohn’s disease, GENOME MED 5:, 2013 | Nagy Zs, Czimmerer Zs, Nagy L: Pro-inflammatory cytokines negatively regulate PPARg mediated gene expression in both human and murine macrophages via multiple mechanisms, IMMUNOBIOLOGY 218: (11) 1336-1344, 2013 | Varga T, Mounier R, Gogolak P, Poliska S, Chazaud B, Nagy L: Tissue LyC6- macrophages are generated in the absence of circulating LyC6- monocytes and Nur77 in a model of muscle regeneration., J IMMUNOL 191: (11) 5695-5701, 2013 | Czimmerer Z, Varga T, Poliska S, Nemet I, Szanto A, Nagy L: Identification of novel markers of human alternative macrophage activation including potential endogenous PPARγ ligand production mechanisms, IMMUNOBIOLOGY 217: (12) 1301-1314, 2012 | Nagy, L., Szanto, A., Szatmari, I. and Szeles, L.: Decision-making by macrophages and dendritic cells using heterodimeric nuclear receptors to sense their lipid environment, Physiological Reviews 92(2) 739-789, 2012 | Nagy, Z., Czimmerer Z. and Nagy, L.: Nuclear receptor mediated mechanisms of macrophage cholesterol metabolism, Cellular and Molecular Endocrinology, 2012 | Czimmerer, Z, Varga, T., Poliska, S., Nemet, I., Szanto, A. and Nagy, L.: Identification of novel markers of human alternative macrophage activation including potential endogenous PPARγ ligand production mechanisms, Immunobiology 217: 1301-1314, 2012 | Nagy, L: Would eating carrots protect your liver? A new role involving NKT cells for retinoic acid in hepatitis, European Journal of Immunology 42:1677-1680, 2012 | Czimmerer Z, Hulvely J, Simandi Z, Varallyay E, Havelda Z, Szabo E, Varga A, Dezso B, Balogh M, Horvath A, Domokos B, Torok Z, Nagy L, Balint BL: A versatile method to design stem-loop primer-based quantitative PCR assays for detecting small regulatory RNA molecules., PLOS ONE 8: (1) e55168, 2013 | Dozsa A, Dezso B, Toth BI, Bacsi A, Poliska S, Camera E, Picardo M, Zouboulis CC, Biro T, Schmitz G, Liebisch G, Ruhl R, Remenyik E, Nagy L: PPARgamma-Mediated and Arachidonic Acid-Dependent Signaling is Involved in Differentiation and Lipid Production of Human Sebocytes., J INVEST DERMATOL 1: (1) 1, 2013 | Gyongyosi A, Szatmari I, Pap A, Dezso B, Pos Z, Szeles L, Varga T, Nagy L: RDH10, RALDH2 and CRABP2 are required components of PPARg-directed all-trans-retinoic acid synthesis and signaling in human dendritic cells, J LIPID RES 54: (9) 2458-2474, 2013 | I Cuaranta-Monroy, Nagy L: PPARy needs a helping hand to make fat, CELL DEATH DIFFER 20: 1599-1600, 2013 | Kiss M, Czimmerer Zs, Nagy L: The role of lipid-activated nuclear receptors in shaping macrophage and dendritic cell function - from physiology to pathology, J ALLERGY CLIN IMMUN &: (132) 264-286, 2013 | Nagy G, Daniel B, Jonas D, Nagy L, Barta E: A novel method to predict regulatory regions
based on histone mark landscapes
in macrophages, IMMUNOBIOLOGY 218: (11) 1416-1427, 2013 | Nagy Zs, Czimmerer Zs, Nagy L: Pro-inflammatory cytokines negatively regulate PPARg mediated gene expression in both human and murine macrophages via multiple mechanisms, IMMUNOBIOLOGY 218: (11) 1336-1344, 2013 | Nagy Zs, Ross J, Rodriguez G, Balint L B, Szeles L, Nagy L, Kirken R A: Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target, PLOS ONE 8: (2) , 2013 | Szenasi T, Kenesi E, Nagy A, Molnar A, Balint BL, Zvara A, Csabai Z, Deak F, Boros Olah B, Mates L, Nagy L, Puskas LG, Kiss I: Hmgb1 can facilitate activation of the matrilin-1 gene promoter by Sox9 and L-Sox5/Sox6 in early steps of chondrogenesis., BBA-GENE REGUL MECH 1829: (10) 1075-1091, 2013 | Varga T, Mounier R, Gogolak P, Poliska S, Chazaud B, Nagy L: Tissue LyC6- macrophages are generated in the absence of circulating LyC6- monocytes and Nur77 in a model of muscle regeneration., J IMMUNOL 191: (11) 5695-5701, 2013 | Czimmerer Z, Varga T, Poliska S, Nemet I, Szanto A, Nagy L: Identification of novel markers of human alternative macrophage activation including potential endogenous PPARγ ligand production mechanisms, IMMUNOBIOLOGY 217: (12) 1301-1314, 2012 | Brazda P, Krieger J, Daniel B, Jonas D, Szekeres T, Langowski J, Tóth K, Nagy L, Vámosi G: Ligand binding shifts highly mobile RXR to chromatin-bound state in a coactivator-dependent manner as revealed by single cell imaging., MOL CELL BIOL 34: (7) 1234-1245, 2014 | Cuaranta-Monroy I, Simandi Z, Kolostyak Z, Doan Xuan Quang Minh, Szilard Poliska, Bacso Z, Nagy L: Highly efficient differentiation of embryonic stem cells into adipocytes by ascorbic acid, STEM CELL RES 13: 88-97, 2014 | Daniel B, Balint BL, Nagy Zs, Nagy L: Mapping the genomic binding sites of the activated retinoid x receptor in murine bone marrow-derived macrophages using chromatin immunoprecipitation sequencing., METHODS MOL BIOL 1204: 15-24, 2014 | Daniel B, Nagy G, Hah H, Horvath A, Czimmerer Z, Poliska P, Gyuris T, Keirsse J, Gysemans C, Ginderachter J, Balint B L, Evans R M, Barta E, Nagy L: The Active Enhancer Network Operated by Liganded RXR Supports Angiogenic Activity in Macrophages, GENE DEV 28: (14) 1562-1577, 2014 | Daniel B, Nagy G, Nagy L: The intriguing complexities of mammalian gene regulation: How to link enhancers to regulated genes. Are we there yet?, FEBS LETT 588: (15) 2379-2391, 2014 | Dozsa A, Dezso B, Toth BI, Bacsi A, Poliska S, Camera E, Picardo M, Zouboulis CC, Biro T, Schmitz G, Liebisch G, Ruhl R, Remenyik E, Nagy L: PPARgamma-Mediated and Arachidonic Acid-Dependent Signaling is Involved in Differentiation and Lipid Production of Human Sebocytes., J INVEST DERMATOL 134: (4) 910-920, 2014 | Daniel B, Nagy G, Hah H, Horvath A, Czimmerer Z, Poliska P, Gyuris T, Keirsse J, Gysemans C, Ginderachter J, Balint B L, Evans R M, Barta E, Nagy L: The Active Enhancer Network Operated by Liganded RXR Supports Angiogenic Activity in Macrophages, GENE DEV 28: (14) 1562-1577, 2014 | Gyongyosi A, Docs O, Czimmerer Z, Orosz L, Horvath A, Torok O, Mehes G, Nagy L, Balint BL: Measuring expression levels of small regulatory RNA molecules from body fluids and formalin-fixed, paraffin-embedded samples, METHODS MOL BIOL 1182: 105-119, 2014 | Simándi Zoltán, Czipa Erik, Horváth Attila, Kőszeghy Áron, Bordás Csilla, Póliska Szilárd, Juhász István, Imre László, Szabó Gábor, Dezső Balázs, Barta Endre, Sauer Sascha, Károlyi Katalin, Kovács Ilona, Hutóczky Gábor, Bognár László, Klekner Álmos, Szűcs Péter, Bálint Bálint László, Nagy László: PRMT1 and PRMT8 regulate retinoic acid dependent neuronal differentiation with implication to neuropathology, STEM CELLS Epub ahead of print: &, 2014 | Daniel B, Nagy G, Nagy L: The intriguing complexities of mammalian gene regulation: How to link enhancers to regulated genes. Are we there yet?, FEBS LETT 588: (15) 2379-2391, 2014 | Brignull LM, Czimmerer Z, Saidi H, Daniel B, Villela I, Bartlett NW, Johnston SL, Meira LB, Nagy L, Nohturfft A: Reprogramming of lysosomal gene expression by interleukin-4 and Stat6., BMC GENOMICS 14: , 2013 | Daniel B, Nagy G, Hah H, Horvath A, Czimmerer Z, Poliska P, Gyuris T, Keirsse J, Gysemans C, Ginderachter J, Balint B L, Evans R M, Barta E, Nagy L: The Active Enhancer Network Operated by Liganded RXR Supports Angiogenic Activity in Macrophages, GENE DEV 28: (14) 1562-1577, 2014 | Gyongyosi A, Docs O, Czimmerer Z, Orosz L, Horvath A, Torok O, Mehes G, Nagy L, Balint BL: Measuring expression levels of small regulatory RNA molecules from body fluids and formalin-fixed, paraffin-embedded samples, METHODS MOL BIOL 1182: 105-119, 2014 | Kiss M, Czimmerer Zs, Nagy L: The role of lipid-activated nuclear receptors in shaping macrophage and dendritic cell function - from physiology to pathology, J ALLERGY CLIN IMMUN &: (132) 264-286, 2013 | Czimmerer Z, Hulvely J, Simandi Z, Varallyay E, Havelda Z, Szabo E, Varga A, Dezso B, Balogh M, Horvath A, Domokos B, Torok Z, Nagy L, Balint BL: A versatile method to design stem-loop primer-based quantitative PCR assays for detecting small regulatory RNA molecules., PLOS ONE 8: (1) e55168, 2013 | Nagy Zs, Ross J, Rodriguez G, Balint L B, Szeles L, Nagy L, Kirken R A: Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target, PLOS ONE 8: (2) , 2013 | Szenasi T, Kenesi E, Nagy A, Molnar A, Balint BL, Zvara A, Csabai Z, Deak F, Boros Olah B, Mates L, Nagy L, Puskas LG, Kiss I: Hmgb1 can facilitate activation of the matrilin-1 gene promoter by Sox9 and L-Sox5/Sox6 in early steps of chondrogenesis., BBA-GENE REGUL MECH 1829: (10) 1075-1091, 2013 | Nagy G, Daniel B, Jonas D, Nagy L, Barta E: A novel method to predict regulatory regions
based on histone mark landscapes
in macrophages, IMMUNOBIOLOGY 218: (11) 1416-1427, 2013 | I Cuaranta-Monroy, Nagy L: PPARy needs a helping hand to make fat, CELL DEATH DIFFER 20: 1599-1600, 2013 | Nagy, L., Szanto, A., Szatmari, I. and Szeles, L.: 27. Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response, Physiological Reviews 92(2) 739-789, 2012 | Nagy, Z., Czimmerer Z. and Nagy, L.: Nuclear receptor mediated mechanisms of macrophage cholesterol metabolism, Cellular and Molecular Endocrinology, 2012 | Nagy, L: Would eating carrots protect your liver? A new role involving NKT cells for retinoic acid in hepatitis, European Journal of Immunology 42:1677-1680, 2012 |
![](img/space.gif)
|
|
|
![](img/shadow_right_up.gif)
|
![](img/shadow_left_bottom.gif)
|
![](img/shadow_right_bottom.gif)
|
![](img/space.gif)
Back »
|
![](img/space.gif) |
|