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Establishment of reliable of human and canine atrial and ventricular action potential computer models
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List of publications |
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Muntean DM, Kiss L, Jost N, Baczkó I.: ATP-Sensitive Potassium Channel Modulators and Cardiac Arrhythmias: an Update, Curr Pharm Des. epub, 2014 | Oliver J. Britton, Alfonso Bueno-Orovio, Laszlo Virag, Andras Varro, Blanca Rodriguez: Effect of Inter-Subject Variability in Determining Response to IKr Block in Human Ventricular Myocytes, Computing in Cardiology, 2014 | N Jost, Zs Kohajda, A Horváth, N Morvai, J Levijoki, P Pollesello, T Koskelainen, L Otsomaa, I Leprán, J Gy Papp, A Varró, L Virág: Effects of ORM-10962, a novel inhibitor of sodium/calcium exchanger, on ion currents of canine cardiomyocytes, and its antiarrhythmic action in guinea pigs, Heart Rhythm, 11(5S), S172,, 2014 | Petrus, Alexandra, Duicu O, Privistirescu A, Sturza A, Noveanu L, Muntean D, Baczkó I, Jost N: Modulation of mitochondrial respiration by novel ATP-sensitive poassium channel openers, Program and Abstract book of the European Section Meeting of the International Academy of Cardiovascular Sciences (IACS) (ISBN: 978-963-306-329-3), 2014 | Muntean DM, Kiss L, Jost N, Baczkó I.: ATP-Sensitive Potassium Channel Modulators and Cardiac Arrhythmias: an Update, Curr Pharm Des. 21(8):1091-1102, 2015 | Andersen-Tawil syndrome. Ördög B, Hategan L, Kovács M, Seprényi G, Kohajda Z, Nagy I, Hegedűs Z, Környei L, Jost N, Katona M, Szekeres M, Forster T, Papp JG, Varró A, Sepp R.: Identification and functional characterisation of a novel KCNJ2 mutation, Val302del, causing Andersen-Tawil syndrome., Can J Physiol Pharmacol, 93(7):569-75, 2015 | Nagy N, Szél T, Jost N, Tóth A, Gy Papp J, Varró A.: Novel experimental results in human cardiac electrophysiology: measurement of the Purkinje fibre action potential from the undiseased human heart., Can J Physiol Pharmacol. 93(9):803-180, 2015 | Baczkó I, Jost N, Varró A.: Cardioprotection and arrhythmias, Part I., 93(7):v. doi: 10.1139/cjpp-2015-0198, 2015 | Baczkó I, Jost N, Varró A.: Cardioprotection and arrhythmias, Part 2, Can J Physiol Pharmacol, 93(9):v. doi: 10.1139/cjpp-2015-0400, 2015 | Petruş A, Duicu OM, Sturza A, Noveanu L, Kiss L, Dănilă M, Baczkó I, Muntean DM, Jost N.: Modulation of mitochondrial respiratory function and ROS production by novel benzopyran analogues., Can J Physiol Pharmacol, 93(9):811-8, 2015 | Nagy N, Kormos A, Kohajda Z, Szebeni Á, Szepesi J, Pollesello P, Levijoki J, Acsai K, Virág L, Nánási PP, Papp JG, Varró A, Tóth A: Selective Na(+) /Ca(2+) exchanger inhibition prevents Ca(2+) overload-induced triggered arrhythmias., Br J Pharmacol. 171(24):5665-5681, 2014 | Orvos P, Virág L, Tálosi L, Hajdú Z, Csupor D, Jedlinszki N, Szél T, Varró A, Hohmann J.: Effects of Chelidonium majus extracts and major alkaloids on hERG potassium channels and on dog cardiac action potential - a safety approach., Fitoterapia, 100:156-165, 2015 | Jost N, Muntean DM, Christ T.: Cardiac Arrhythmias: Introduction, Electrophysiology of the Heart, Action Potential and Membrane Currents, Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Eds. Jagadeesh G, Balakumar P, Maungh-U K, pp 977-1002, Adis_Springer Publishing, doi: 10.1007/978-3-319-15, 2015 | Christ T, Pecha S, Jost N.: Treatment of Atrial Fibrillation and Atrial Flutter., Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Eds. Jagadeesh, Balakumar, Maungh-U, pp 977-1002, Adis_Springer Publish, doi: 10.1007/978-3-319-15961-4_50, 2015 | Petruş A, Duicu OM, Sturza A, Noveanu L, Kiss L, Dănilă M, Baczkó I, Muntean DM, Jost N.: Modulation of mitochondrial respiratory function and ROS production by novel benzopyran analogues., Can J Physiol Pharmacol, 93(9):811-8, 2015 | Jost N, Muntean DM, Christ T.: Cardiac Arrhythmias: Introduction, Electrophysiology of the Heart, Action Potential and Membrane Currents, Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Eds. Jagadeesh G, Balakumar P, Maungh-U K, pp 977-1002, Adis_Springer Publishing, doi: 10.1007/978-3-319-15, 2015 | Pueyo E, Dangerfield CE, Britton OJ, Virág L, Kistamás K, Szentandrássy N, Jost N, Varró A, Nánási PP, Burrage K, Rodríguez B: Experimentally-Based Computational investigation into beat-to-beat variability in ventricular repolarization and its response to ionic current inhibition, PLoS ONE 11(3): e0151461. doi:10.1371/journal.pone.0151461, 2016 | Major P, Baczkó I, Hiripi L, Odening KE, Juhász V, Kohajda Z, Horváth A, Seprényi G, Kovács M, Virág L, Jost N, Prorok J, Ördög B, Doleschall Z, Nattel S, Varró A, Bősze Z: A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of KCNE1 gene, British Journal of Pharmacology, 173, 2046–2061, 2016 | Baczkó I, Jost N, Virág L, Bősze Zs, Varró A: Rabbit models as tools for preclinical cardiac electrophysiological safety testing: importance of repolarization reserve, Progress in Biophys and Mol Biol, 121(2):157-168, 2016 | Christ T, Kovács PP, Acsai K, Knaut M, Eschenhagen T, Jost N, Varró A, Wettwer E, Ravens U: Block of Na+/Ca2+ exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation, Eur J Pharmacol, 788, 286–293, 2016 | Geramipour A, Kohajda Zs, Corici C, Prorok J, Szakonyi Zs, Oravecz K, Márton Z, Nagy N, Tóth A, Acsai K, Virág L, Varró A, Jost N: The investigation of the cellular electrophysiological and antiarrhythmic effects of a novel selective sodium-calcium exchanger inhibitor GYKB-6635 in canine and guinea p, Canadian Journal Physiology and Pharmacology, 94(10), 1090-1101, 2016 | Pueyo E, Dangerfield CE, Britton OJ, Virág L, Kistamás K, Szentandrássy N, Jost N, Varró A, Nánási PP, Burrage K, Rodríguez B: Experimentally-Based Computational investigation into beat-to-beat variability in ventricular repolarization and its response to ionic current inhibition, PLoS ONE 11(3): e0151461. doi:10.1371/journal.pone.0151461, 2016 | Major P, Baczkó I, Hiripi L, Odening KE, Juhász V, Kohajda Z, Horváth A, Seprényi G, Kovács M, Virág L, Jost N, Prorok J, Ördög B, Doleschall Z, Nattel S, Varró A, Bősze Z: A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of KCNE1 gene, British Journal of Pharmacology, 173, 2046–2061, 2016 | Baczkó I, Jost N, Virág L, Bősze Zs, Varró A: Rabbit models as tools for preclinical cardiac electrophysiological safety testing: importance of repolarization reserve, Progress in Biophys and Mol Biol, 121(2):157-168, 2016 | Geramipour A, Kohajda Zs, Corici C, Prorok J, Szakonyi Zs, Oravecz K, Márton Z, Nagy N, Tóth A, Acsai K, Virág L, Varró A, Jost N: The investigation of the cellular electrophysiological and antiarrhythmic effects of a novel selective sodium-calcium exchanger inhibitor GYKB-6635 in canine and guinea p, Canadian Journal Physiology and Pharmacology, 94(10), 1090-1101, 2016 | Kohajda Z, Farkas-Morvay N, Jost N, Nagy N, Geramipour A, Horváth A, Varga RS, Hornyik T, Corici C, Acsai K, Horváth B, Prorok J, Ördög B, Déri S, Tóth D, Levijoki J, Pollesello P, Koskelainen T, Otsomaa L, Tóth A, Baczkó I, Leprán I, Nánási PP, Papp JG, Varró A, Virág L: The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments., PLoS One. 11(11):e0166041. doi: 10.1371/journal.pone.016604, 2016 | Gurabi Z, Patocskai B, Györe B, Virág L, Mátyus P, Papp JG, Varró A, Koncz I: Different electrophysiological effects of the levo- and dextro-rotatory isomers of mexiletine in isolated rabbit cardiac muscle, Can J Physiol Pharmacol, 95(7):830-836. doi: 10.1139/cjpp-2016-0599, 2017 | Britton OJ, Bueno-Orovio A, Virág L, Varró A, Rodriguez B: The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study, Front Physiol. 2017 May 5;8:278. doi: 10.3389/fphys.2017.00278. eCollection, 2017 |
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