Host-vector-pathogen coevolution strategies: role of pathogens in shaping bat and bat-parasite population dynamics  Page description

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Details of project

  
Identifier
132794
Type K
Principal investigator Sándor, Attila
Title in Hungarian Gazda-parazita-kórokozó koevolúciós stratégiák: a kórokozók fontossága a denevérek és elősködőik populáció-dinamikájában
Title in English Host-vector-pathogen coevolution strategies: role of pathogens in shaping bat and bat-parasite population dynamics
Keywords in Hungarian gazda-parazita kapcsolatok, Chiroptera, Diptera, Cimicidae, ko-evolúció, patogének, vektorok
Keywords in English host-parasite relatioships, Chiroptera, Diptera, Cimicidae, co-evolution, pathogens, vectors
Discipline
Veterinary parasitology (Council of Complex Environmental Sciences)70 %
Microbiology: virology, bacteriology, parasitology, mycology (Council of Medical and Biological Sciences)20 %
Ortelius classification: Animal parasitology
Evolutionary ecology and genetics, coevolution (Council of Complex Environmental Sciences)10 %
Panel Plant and animal breeding
Department or equivalent Department of Parasitology and Zoology (University of Veterinary Medicine Budapest)
Participants Hornok, Sándor
Szekeres, Sándor
Takács, Nóra
Starting date 2019-12-01
Closing date 2024-11-30
Funding (in million HUF) 35.056
FTE (full time equivalent) 6.00
state running project





 

Final report

  
Results in Hungarian
Projektünk legfőbb célja az volt, hogy feltárjuk a paraziták által alkalmazott olyan stratégiákat, amelyekkel növelik esélyeiket az új gazdaszervezetek megfertőzésére/kolonizálására, illetve, hogy feltérképezzük a gazdaszervezetek válaszait, megismerve azokat a viselkedési mechanizmusokat amelyek segítségével elkerülhetik a fertőződést. Úgy terepi, mint kísérletes vizsgálatokat végeztünk egy háromszereplős rendszerben, a denevér-vektor-patogén ciklus modelljére támaszkodva. Természetes és ltervezett laborkisérletek során számos hipotézist teszteltünk a gazdaválasztással, a kórokozó/parazita elkerülésével és a gazdamanipulációval kapcsolatban. Emellett az egyes vektorfajok kórokozó-átvitelben betöltött jelentőségének megállapítása érdekében összehasonlító vizsgálatokat végeztünk több kórokozó csoporttal. Kísérletileg vizsgáltuk az óvantagok kórokozó-átvitelét, a denevérlegyek vektorkapacitását zoonótikus baktériumok, valamint a heemosporidiumok, például a Polychromophilus spp. számára. Vizsgálataink célja elsősorban az olyan kórokozók mikrobiológiai kimutatása volt, amelyek előfordulása valószínűsíthető a palearktikus denevérek öt legfontosabb ízeltlábú parazita csoportjánál (denevérlegyek, poloskák, bolhák, kullancsok és atkák). Így sikerült új adatokat szolgáltatnunk a kullancsok és legyek denevér-maláriában betöltött jelentőségéről, megvilágítani a különböző denevérlegyek, atkák és bolhák Bartonella-átvitelében játszott szerepét, de azt is, hogy az egyéni mikrobiom milyen jelentőséggel bírhat a gazda-parazita immunkonfliktusok intenzitásának csökkentésében.
Results in English
Our aim with this project was to elucidate the main strategies used by parasites to increase their chances to infest/colonize new hosts and to decode the hosts’ responses to avoid or reduce this by behavioural mechanisms. We used experimental and descriptive studies in a three-actor system, relying on the model of the bat-vector-pathogen cycle. Using both in-situ, as well experimental settings we tested several hypotheses on host choice, pathogen/parasite avoidance and host-manipulation. In addition, in order to establish the importance of individual vector species in pathogen transmission, we implemented comparative assessments of phylogenetically close pathogens. We experimentally tested soft ticks for pathogen transfer, and tried to characterize bat flies for their capacity in vectoring zoonotic bacteria, as well haemosporidians, such as Polychromophilus spp. Our studies targeted the presence of zoonotic pathogens in five arthropod parasite clades (bat flies, bat bugs, fleas, ticks and gamasid mites) of Palearctic bats. As such we managed to provide new data on the importance of ticks and flies for bat-malaria, to elucidate the role played by different bat flies, gamasid acarians and fleas in Bartonella spp. transfer, but also on the importance of individual microbiome may have in reducing the intensity of host-parasite immune conflicts.
Full text https://www.otka-palyazat.hu/download.php?type=zarobeszamolo&projektid=132794
Decision
Yes





 

List of publications

  
Sándor, AD: Intraguild predation by Eurasian Eagle-owl Bubo bubo on Booted Eagle Aquila pennata and Long-legged Buzzard Buteo rufinus, Acta Ornithologica, 2022
Hornok, S, AM Cini Bruno, N Takács, G Keve, AD Sándor, J Kontschán: An update on the occurrence of flies (Diptera: Muscidae, Calliphoridae) and sucking lice (Phthiraptera: Anoplura) of veterinary importance in Malta: First record of Lucil, Frontiers in Veterinary Science, 2023
Hornok, S, O Plantard, J Kontschán, N Takács, D Fedorov, AD Mihalca, AD Sándor: Phylogenetic analyses of Ixodes rugicollis with notes on its morphology in comparison with Ixodes cornutus, Parasites & Vectors, 2023
Corduneanu, A, A Wu-Chuang, A Maitre, D Obregon, AD Sándor, A Cabezas-Cruz: Structural differences in the gut microbiome of bats using terrestrial vs. aquatic feeding resources, BMC Microbiology, 2023
Matei, IA, Z Kalmár, A Balea, M Mihaiu, AD Sándor, A Cocian, S Crăciun, C Bouari, VT Briciu, N Fiț: The role of wild boars in the circulation of some tick-borne pathogens: the first evidence of Rickettsia monacensis presence., Animals, 2023
Barti, L, Sándor AD: First records of Mediterranean Horseshoe Bat (Rhinolophus euryale Blasius, 1853) (Mammalia: Chiroptera) in Romanian Dobrudja, Black Sea region, Acta Zoologica Bulgarica, 2023
Kalmár, Z, AD Sándor, A Balea, S Borșan, IA Matei, AM Ionică, CM Gherman, AD Mihalca, A Cozma-Petruț, V Mircean, A Györke: Toxoplasma gondii in small mammals in Romania: the influence of host, season and sampling location, BMC Veterinary Research, 2023
Corduneanu, A, Z Zając, J Kulisz, A Foucault-Simonin, S Moutailler, A Wu-Chuang, Á Péter, AD Sándor, A Cabezas-Cruz: Detection of bacterial and protozoan pathogens in individual bats and their ectoparasites using high throughput microfluidic real-time PCR, Microbiology Spectrum, 2023
Bendjeddou, M.L., F. Khelfaoui, A. Abiadh, N. Mechouk, A.D. Mihalca, A.D. Sándor: Bat ectoparasites (Acari, Diptera, Hemiptera, Siphonaptera) in the Grand Maghreb (Algeria, Libya, Mauritania, Morocco and Tunisia): a literature review and new data, Acta Parasitologica, 2024
Sándor, AD, A Corduneanu, S Hornok, AD Mihalca, Á Péter: Season and host-community composition inside roosts may affect host-specificity of bat flies, Scientific Reports, 2024
Sándor, AD, A Corduneanu, M Orlova, S Hornok, A Cabezas-Cruz, A Foucault-Simonin, J Kulisz, Z Zając, M Borzan: Diversity of bartonellae in wing mites (Acari: Mesostigmata: Macronyssidae and Spinturnicidae) of boreal forest bats: effect of host specificity of mites and habitat selection of hosts on vector potential, Medical and Veterinary Entomology, 2024
Hornok, S., J. Daccord, N. Takács, J. Kontschán, B. Tuska-Szalay, A.D. Sándor, S. Szekeres, M.L. Meli, R. Hofmann-Lehmann: Investigation on haplotypes of ixodid ticks and retrospective finding of Borrelia miyamotoi in bank vole (Myodes glareolus) in Switzerland, Ticks and Tick-borne Diseases, 2022
Péter, Á., AD. Mihalca, D. Haelewaters, AD. Sándor: Focus on hyperparasites: Biotic and abiotic traits affecting the prevalence of parasitic fungi on bat ectoparasites, Frontiers in Ecology and Evolution, 2022
Péter, Á., AD. Mihalca, AD. Sándo: Annotated checklist of the bat flies (Diptera: Nycteribiidae) of Romania, Zootaxa, 2022
Hornok, S., SA. Boldogh, N. Takács, J. Kontschán, S. Szekeres, E. Sós, AD. Sándor, Y. Wang, B. Tuska-Szalay: Molecular epidemiological study on ticks and tick-borne protozoan parasites (Apicomplexa: Cytauxzoon and Hepatozoon spp.) from wild cats (Felis silvestris), Mustelidae an, Parasites & Vectors 15: 174., 2022
Hornok, S., R. Berkecz, E. Sós, A.D. Sándor, T. Körmöczi, J. Kontschán, A. Hunyadi: Arthropod molting hormones (ecdysteroids) are present in the blood of insectivorous bats, Mammal Review 52: 317-321., 2022
Bendjeddou, ML., I. Bouam, S. Aulagnier, SE. Abdalaziz, K. Etayeb, AD. Mihalca, AD. Sándor: First record of the lesser horseshoe bat, Rhinolophus hipposideros (Borkhausen, 1797), in Libya and potential distribution in North Africa, Mammalia 86: 328-332., 2022
Keve, G., AD. Sándor, S. Hornok: Hard ticks (Acari: Ixodidae) associated with birds in Europe: review of literature data, Frontiers in Veterinary Science 9:928756., 2022
Reynolds, C., J. Kontschán, N. Takács, N. Solymosi, AD. Sándor, G. Keve, S. Hornok: Shift in the seasonality of ixodid ticks after a warm winter in an urban habitat with notes on morphotypes of Ixodes ricinus and data in support of cryptic species within, Experimental and Applied Acarology 88: 127–138., 2022
Sándor AD, Corduneanu A, Péter A, Mihalca AD, Barti L, Csősz I, Szőke K, Hornok S: Geographical distribution, host selection and seasonality of occurrence in bat-specialist ticks of Europe, 10th Tick and Tick Borne Pathogen Conference, 29 August and 2 September 2022, Murghiol, Danube Delta, Romania, 2022
Sándor, Ad., A. Corduneanu, Á. Péter, L. Barti, I. Csősz, S. Hornok: Anthropogenic roost selection in cave-dwelling bat species: a role for parasites?, 6th International Berlin Bat Meeting: The human perspective on bats (22nd - 24th March 2021, online), 2021
Sándor, D.A., Á. Péter, A. Corduneanu, L. Barti, I. Csősz, Z. Kalmár, S. Hornok, J. Kontschán, A.D. Mihalca: Wide distribution and diversity of malaria-related haemosporidian parasites (Polychromophilus spp.) in bats and their ectoparasites in Eastern Europe, Microorganisms, 2021
Matei, IM; A. Corduneanu; A.D. Sándor; A.M. Ionică; L. Panait; Z. Kalmár; T. Ivan; I. Papuc; C. Bouari; N. Fit; A.D. Mihalca: Rickettsia spp. in bats of Europe: high prevalence of Rickettsia monacensis in two insectivorous bat species, Parasites & Vectors, 2021
Hornok, S., N. Takács, G. Sipos, P. Morandini, A.D. Sándor, S. Szekeres, A. Grima, J. Kontschán: Urban emergence of Dermanyssus gallinae lineage L1 and Ornithonyssus sylviarum in Hungary: phylogenetic differentiation between the roles of migrating vs transported syna, Parasites & Vectors, 2021
Hornok, S., E. Meyer-Kayser, J. Kontschán, N. Takács, O. Plantard, S. Cullen, A. Gaughran, S. Szekeres, G. Majoros, R. Beck, S.A. Boldogh, G. Horváth, C. Kutasi, A.D. Sándor: Morphology of Pholeoixodes species associated with carnivores in the western Palearctic: pictorial key based on molecularly identified Ixodes (Ph.) canisuga, I. (Ph.) hex, Ticks and Tick-borne Diseases, 2021
Péter, Á., L. Barti, A. Corduneanu, S. Hornok, A.D. Mihalca, A.D. Sándor: First record of Ixodes simplex found on a human host, with a review of cases of human infestation by bat-specialist ticks., Ticks and Tick-borne Diseases, 2021
Sándor, A.D., A. D. Mihalca, C. Domșa, Á. Péter, S. Hornok: Argasid ticks of Palearctic bats: distribution, host selection and zoonotic importance, Frontiers in Veterinary Science, 2021
Sándor, A.D, B. Milchev, N. Takács, J. Kontschán, S. Szekeres, S. Hornok: Five ixodid tick species including two morpho-types of Rhipicephalus turanicus on nestlings of Eurasian eagle owl (Bubo bubo) from southeastern Bulgaria, Parasites & Vectors, 2021
Hornok, S., J. Kontschán, N. Takács, AL Chaber, A. Halajian, S. Szekeres, AD. Sándor, O. Plantard: Rickettsiaceae in two reptile-associated tick species, Amblyomma exornatum and Africaniella transversale: first evidence of Occidentia massiliensis in hard ticks (Acari:, Ticks and Tick-borne Diseases, 2022
Matei, I.A., A.M. Ionică, A. Corduneanu, C. Domșa, A.D. Sándor: The presence of Ehrlichia canis in Rhipicephalus bursa ticks collected from ungulates in continental Eastern Europe, Journal of Veterinary Research, 2021
Haelewaters, D., B. Dima, A.I.I. Abdel-Hafiz, M.A. Abdel-Wahab, S.R. Abul-Ezz, I. Acar, E. Aguirre-Acosta, M.C. Aime, S. Aldemir, M. Ali, O. Ayala-Vásquez, M.S. Bakhit, H. Bashir, E. Battistin, E. Bendiksen, R. Castro-Rivera, Ö. Faruk Çolak, A. De Kesel, J. Isaac de la Fuente, A. Dizkırıcı, S. Hussain, G. Maarten Jansen, O. Kaygusuz, A. Nasir Khalid, J. Khan, A.A. Kiyashko, E. Larsson, C.R. Martínez-González, O.V. Morozova, A.R. Niazi, M.E. Noordeloos, T.H. Giang Pham, E.S. Popov, N.V. Psurtseva, N. Schoutteten, H. Sher, I. Türkekul, A. Verbeken, H. Ahmad, N. ul Sehar Afshan, P. Christe, M. Fiaz, O. Glaizot, J. Liu, J. Majeed, W. Markotter, A. Nagy, H. Nawaz, V. Papp, Á. Péter, W.P. Pfliegler, T. Qasim, M. Riaz, A.D. Sándor, T. Szentiványi, H. Voglmayr, N. Yousaf, I. Krisai-Greilhuber: Fungal Systematics and Evolution: FUSE 6, Sydowia 72: 231–356, 2020
Corduneanu, A., AD Mihalca, AD. Sándor, S Hornok, M Malmberg, N. Pin Viso, E Bongcam-Rudloff: The bacteriome of insectivorous bats from Central and South Eastern Europe, Comparative Immunology, Microbiology & Infectious Disease, 2021
Péter, Á., A.D. Mihalca, A.D. Sándor: First report of the bat fly species Basilia italica in Romania., Biodiversity Data Journal, 2021
de Groot, M.D., I. Dumolein, T. Hiller, A.D. Sándor, T. Szentiványi, M. Schilthuizen, M.C. Aime, A. Verbeken, D. Haelewaters: On the fly: Tritrophic associations of bats, bat flies, and fungi, Journal of Fungi, 2020
Péter, Á., A.D. Mihalca, A.D. Sándor: First report of the bat fly species Basilia italica in Romania., Biodiversity Data Journal, 2021
de Groot, M.D., I. Dumolein, T. Hiller, A.D. Sándor, T. Szentiványi, M. Schilthuizen, M.C. Aime, A. Verbeken, D. Haelewaters: On the fly: Tritrophic associations of bats, bat flies, and fungi, Journal of Fungi, 2020
Corduneanu, A., AD Mihalca, AD. Sándor, S Hornok, M Malmberg, N. Pin Viso, E Bongcam-Rudloff: The heart microbiome of insectivorous bats from Central and South Eastern Europe, Comparative Immunology, Microbiology & Infectious Disease, 2021



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