Amplification of the mutant EGFR gene: molecular mechanism and role in therapeutic resistance

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Identifier

134818

Type

Principal investigator

Németh, Eszter

Title in Hungarian

A mutáns EGFR gén amplifikációjának molekuláris mechanizmusa és szerepe a terápia rezisztenciában

Title in English

Amplification of the mutant EGFR gene: molecular mechanism and role in therapeutic resistance

Keywords in Hungarian

amplifikáció, extrakromoszomális cirkuláris DNS, rák, rezisztencia, teljes genom szekvenálás

Keywords in English

amplification, extrachromosomal circular DNA, cancer, therapy, resistance, whole genome sequencing

Discipline

DNA synthesis, modification, repair, recombination and degradation (Council of Medical and Biological Sciences)	50 %
Bioinformatics (Council of Medical and Biological Sciences)	30 %
Cancer and its biological basis (Council of Medical and Biological Sciences)	20 %
Ortelius classification: Oncology

Panel

Molecular and Structural Biology and Biochemistry

Department or equivalent

Institute of Molecular Life Sciences (Research Center of Natural Sciences)

Starting date

2020-12-01

Closing date

2024-09-30

Funding (in million HUF)

25.497

FTE (full time equivalent)

2.40

state

running project