The molecular mechanisms underlying the anti-cancer therapeutic PARP inhibitor sensitivity of POLE3 and POLE4 deficient cells  Page description

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Details of project

  
Identifier
143248
Type K
Principal investigator Timinszky, Gyula
Title in Hungarian A POLE3 és POLE4 deficiens sejtek a daganatellenes PARP gátlókkal szembeni érzékenységének molekuláris alapjai
Title in English The molecular mechanisms underlying the anti-cancer therapeutic PARP inhibitor sensitivity of POLE3 and POLE4 deficient cells
Keywords in Hungarian daganatellenes terápia, PARP gátló, sejtciklus szabályozás, kromatin szabályozás
Keywords in English anti-cancer therapy, PARP inhibitor, Cell-cycle regulation, chromatin regulation
Discipline
Cell cycle and division (Council of Medical and Biological Sciences)50 %
DNA synthesis, modification, repair, recombination and degradation (Council of Medical and Biological Sciences)30 %
Epigenetics and gene regulation (Council of Medical and Biological Sciences)20 %
Panel Molecular and Structural Biology and Biochemistry
Department or equivalent Institute of Genetics (HUN-REN Biological Research Centre Szeged)
Participants Fajka Boja, Roberta
Hegedűs, Zoltán
Mórocz, Mónika
Szüts, Dávid
Starting date 2022-12-01
Closing date 2026-11-30
Funding (in million HUF) 48.000
FTE (full time equivalent) 4.10
state running project




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