Examination of the physiological role of salsolinol in dopaminergic neurotransmission  Page description

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Details of project

  
Identifier
43370
Type K
Principal investigator Nagy M., György
Title in Hungarian A salsolinol dopaminerg transzmisszióban betöltött fiziológiás szerepének vizsgálata
Title in English Examination of the physiological role of salsolinol in dopaminergic neurotransmission
Panel Physiology, Pathophysiology, Pharmacology and Endocrinology
Department or equivalent Neuromorphological and Neuroendocrine Research Laboratory (Office for Research Groups Attached to Universities and Other Institutions)
Participants Bodnár, Ibolya
Fekete, Márton
Homicskó, Krisztián
Tóth, E. Béla
Starting date 2003-01-01
Closing date 2006-12-31
Funding (in million HUF) 11.656
FTE (full time equivalent) 0.00
state closed project





 

Final report

  
Results in Hungarian
Korábban kimutattuk, hogy a hipofízis közti-hátsó lebenyének (NIL) prolaktin (PRL) ürítő hatásért a salsolinol (SAL) felelős. A PRL-szint emelkedéssel párhuzamosan a SAL az eminentia medianaban (ME) csökkenti, míg az elülső lebenyben (AL) növeli cAMP szintet. A SAL-nak egy szerkezeti analógja, az 1MeDIQ képes gátolni a szopási ingerre és a stresszre bekövetkező PRL szint emelkedést. Mindezek alátámasztják korábbi feltevésünket, hogy a SAL az a régóta keresett élettanilag is jelentős prolaktoliberin. Az 1MeDIQ az amfetamin (AMPH)-hoz hasonló psziho-stimuláns hatással is rendelkezik, növeli a plazma katecholamin-szinteket. A perifériás szimpatikus beidegzések műtéti vagy farmakológiás (chlorisondamine) lézióját követően fellépő változások a SAL hatásában világosan jelzik, hogy az 1MeDIQ hatásában a norepinefrin (NE)-erg rendszer kulcsszerepet játszik. A PRL felszabadító hatása mellett a SAL csökkenti a stressz és az 1MeDIQ kiváltotta plazma NE és epinefrin (E) emelkedést. Hasonló kölcsönhatást találtunk az AMPH és a SAL prolaktin elválasztásra gyakorolt hatásában is. A szimpatikus idegelemek által beidegzett szervekben, mint a pitvarban, lépben, májban, vagy az ovariumban, a SAL szelektíven csökkenti a dopamin (DA) koncentrációját. SAL-nak ez a hatása a kivédhető AMPH-előkezeléssel. Összefoglalva, a SAL és az AMPH között kölcsönhatás állapítható meg az elülső lebenyi PRL-ürítés és a szimpatikus végződésekben zajló katecholamin-metabolizmus vonatkozásában egyaránt.
Results in English
We have previously shown that salsolinol (SAL) is responsible for the prolactin (PRL) releasing activity detected in the neurointermediate lobe (NIL) of the pituitary gland. SAL can induce a decrease of cAMP level in the median eminence (ME) and an increase in the anterior lobe (AL). A structural analogue of SAL, 1MeDIQ, can inhibit the elevation of plasma PRL induced by physiological stimuli like suckling or stress. All these data support our assumption that SAL may be the physiologically relevant prolactoliberin. 1MeDIQ has a psycho-stimulant action as well, which is similar to the effect of amphetamine (AMPH) i.e. induces an increase in plasma catecholamine concentrations. Surgical or pharmacological (chlorisondamine) lesions of peripheral sympathetic innervations clearly indicate that norepinephrin (NE)-erg system has pivotal role in the action of 1MeDIQ. SAL, besides its PRL releasing activity, can significantly decrease stress and 1MeDIQ induced increase in plasma NE and epinephrine (E) levels. There is an interaction between AMPH and SAL on pituitary PRL release too. SAL treatment results in a selective decrease in DA content of sympathetically innervated organs like atrium, spleen, liver, ovaries, and salivary gland. This effect of SAL is prevented by AMPH pretreatment. It is clear that there is a mutual interaction between SAL and AMPH not only on PRL release, but their interaction is obvious on the catecholamine “metabolism” of nerve terminals as well.
Full text http://real.mtak.hu/1042/
Decision
Yes





 

List of publications

  
Nagy GM, Bodnár I, Bánky Zs, Halász B: Control of prolactin secretion by excitatory amino acids., Endocrine 28(3): 303-309., 2005
Hashizume T, Shida R, Suzuki S, Nonaka S, Yonezawa C, Yamashita T, Kasuya, Sutoh M, Oláh M, Székács D, Nagy GM: Salsolinol is present in the bovine posterior pituitary gland and stimulates prolactin release both in vivo and in vitro in ruminants., Domest Anim Endocrinol, 2007 Jan 16; (Epud ahead of print), 2006
Radnai B, Mravec B, Bodnár I, Kubovcakova L, Fülöp F, Fekete MIK, Nagy GM, Kvetnansky R: Pivotal role of an endogenous tetrahydroisoquinoline, salsolinol (SAL), in stress-, and suckling-induced release of prolactin (PRL)., Ann N Y Acad Sci. 1018:183-191, 2004
Homicskó KG, Kertész I, Radnai B, Tóth BE, Tóth G, Fülöp F, Fekete MIK, Nagy GM: Binding site of salsolinol: its properties in different regions of the brain and the pituitary gland., Neurochemistry International 42:19-26, 2003
Góth MI, Hubina E, Raptis S, Nagy GM, Tóth BE: Physiological and pathological angiogenesis in the endocrine system., Microscopy Research and Technique 60:98-106, 2003
Zelena D, Makara GB, Nagy GM: Effect of glutamate receptor antagonists on suckling-induced prolactin release in rats., Endocrine 21(2):147-52, 2003
Bodnár I, Mravec B, Kubovcakova L, Tóth EB, Fülöp F., Fekete MIK, Kvetnansky R, Nagy GM: Stress-, as well as suckling-induced prolactin (PRL) response is blocked by a structural analogue of the putative hypophyseotrofic PRL releasing factor, salsolinol (SAL)., Journal of Neuroendocrinology 16(3):208-213, 2004
Mravec B, Bodnar I, Kubovcakova L, Nagy GM, Palkovits M, Kvetnansky R: Inhibitory effect of formalin administration on immobilization-induced epinephrine release., Ann N Y Acad Sci. 1018:105-112, 2004
Naoi M, Maruyama W, Nagy GM: Dopamine-derivatives as endogenous monoamine oxidase inhibitors: Occurrence, metabolism and function in human brains., Neurotoxicology 25(1-2):193-204, 2004
Raptis S, Fekete C, Sarkar S, Rand WM, Emerson CH, Nagy GM, Lechan RM: CART co-contained in TRH neurons of the hypothalamic paraventricular nucleus (PVN) modulates TRH-induced prolactin secretion., Endocrinology 145(4): 1695-1699, 2004
Mravec B, Bodnár I, Fekete MIK, Nagy GM, Kvetnansky R: An antagonist of prolactoliberine induces an increase in plasma catecholamine levels in the rat., Autonomic Neuroscience 115(1-2): 35-40, 2004
Saito TR, Tatsuno T, Takeda A, Hashimoto H, Suzuki M, Terada M, Aoki-Komori S, Tanaka M, Koranyi L, Nagy GM: Effects of i.c.v. administration of leptin on copulatory and ingestive behavior in STZ-induced diabetic male rats., Exp Anim. 53(5):445-51, 2004
Radnai B, Kandár Z, Somogyvári-Vigh A, Mergl Zs, Oláh M, Fülöp F, Vecsernyés M, Nagy GM: Salsolinol induces a decrease in cyclic AMP at the median eminence and an increase at the adenohypophysis in lactating rats., Brain Research Bull. 65(2):105-110, 2005
Bodnár I, Bánky Zs, Nagy GM, Halász B: Non-NMDA glutamate receptor antagonist injected into the hypothalamic paraventricular nucleus blocks the suckling stimulus-induced release of prolactin., Brain Research Bull. 65(2):163-168, 2005
Bodnár I, Szekács D, Oláh M, Okamura H, Vecsernyés M, Fekete MIK, Nagy GM: Effect of neonatal treatment with monosodium glutamate (MSG) on dopamine and DOPA neurons of the medial basal hypothalamus of rats., The probable roles of DOPA as a neurotransmitter. Progress in Pharmacology and Toxicology. (Mannfred A. Hollinger eds, pp 1-6, Taylor and Franceis Publishers, London), 2005
Iván G, Szigeti-Csúcs N, Oláh M, Nagy GM, Góth MI: Treatment of pituitary tumors: Dopamine agonists., Review. Endocrine 28(2): 101-110, 2005
Mravec B, Bodnar I, Uhereczky G, Nagy GM, Richard Kvetnansky R, Palkovits M: Formalin inhibits the stress-induced increase in plasma epinephrine levels., J Neuroendocrinol. 17(11): 727-32, 2005
Jozsa R, Olah A, Comelissen G, Csernus V, Otsuka K, Zeman M, Nagy G, Kaszaki J, Stebelova K, Csokas N, Pan W, Herold M, Bakken EE, Halberg F: Circadian and extracircadian exploration during daytime hours of circulating corticosterone and other endocrine chronomes., Biomed Pharmacother. 59 Suppl 1:S109-16., 2005
Stebelova K, Zeman M, Cornelissen G, Bubenik G, Jozs R, Hardeland R, Poeggeler B, Huether G, Olah A, Nagy G, Csernus V, Kaszaki J, Pan W, Otsuka K, Bakken EE, Halberg F: Chronomics reveal and quantify circadian rhythmic melatonin in duodenum of rats., Biomed Pharmacother. 59 Suppl 1:S209-12, 2005
Jozsa R, Halberg F, Cornélissen G, Zeman M, Kazsaki J, Csernus V, Katinas GS, Wendt H W, Schwartzkopff O, Stebelova K, Dulkova K, Chibisov SM, Engebreston M, Pan W, Bubenik GA, Nagy G, Herold M, Harde: Chronomics, Neuroendocrine feedsidewards and the recording and consulting of nowcasts-forecasts of geomagnetics., Biomed Pharmacother 59 Suppl 1:S24-30, 2005
Zeman M, Jozsa R, Cornelissen G, Stebelova K, Bubenik G, Olah A, Poeggeler B, Huether G, Hardeland R, Nagy G, Csernus V, Pan W, Otsuka K, Halberg F: Chronomics: circadian lead of extrapineal vs. pineal melatonin rhythms with an infradian hypothalamic exploration., Biomed Pharmacother. 59 Suppl 1:S213-9, 2005
Nagy GM, Bodnár I, Bánky Zs, Halász B: Control of prolactin secretion by excitatory amino acids., Review. Endocrine 28(3): 303-309, 2005
Hubina E, Nanzer AM, Hanson MR, Ciccarelli E, Losa M, Gaia D, Papotti M, Terreni MR, Khalaf S, Jordan S, Czirjak S, Hanzely Z, Nagy GM, Goth MI, Grossman AB, Korbonits M: Somatostatin analogues stimulate p27 expression and inhibit the MAP kinase pathway in pituitary tumours., Eur J Endocrinol. 155(2):371-379., 2006
Barabás K, Szegő ÉM, Kaszás A, Nagy GM, Juhász GD, Ábrahám IM: Sex differences in oestrogen-induced p44/42 MAPK phosphorylation in the mouse brain in vivo., J. Neuroendocrinol. 18:621-628., 2006
Hubina E, Nanzer AM, Hanson MR, Ciccarelli E, Losa M, Gaia D, Papotti M, Terreni MR, Khalaf S, Jordan S, Czirjak S, Hanzely Z, Nagy GM, Goth MI, Grossman AB, Korbonits M: Somatostatin analogues stimulate p27 expression and inhibit the MAP kinase pathway in pituitary tumours., Eur J Endocrinol. 155(2):371-379., 2006
Székács D, Bodnár I, Mravec B, Kvetnansky R, Vizi ES, Nagy GM, Fekete MI: The peripheral noradrenergic terminal as possible site of action of salsolinol as prolactoliberin., Neurochemistry International 50(2): 427-434., 2007
Ibolya Bodnár, Dániel Hechtl, Dániel Székács, Márk Oláh, György M. Nagy: Effect of local (intracerebral and intracerebroventricular) administration of tyrosine hydroxylase inhibitor on the neuroendocrine dopaminergic neurons and prolactin release., Clinical Neuroscience, 2007
Dániel Székács, Ibolya Bodnár, György M. Nagy, Márton I.K. Fekete: Salsolinol and the peripheral sympathetic activity: the effects of hypophysectomy, adrenalectomy and adrenal medullectomy., Clinical Neuroscience, 2007



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