Investigation of apparent injury in the vascular and cardiorespiratory system due to ischemia and reperfusion  Page description

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Details of project

  
Identifier
43403
Type K
Principal investigator Papp, Lajos
Title in Hungarian Az iszkémiás és posztiszkémiás vaszkuláris és kardiorespiratorikus károsodások tanulmányozása
Title in English Investigation of apparent injury in the vascular and cardiorespiratory system due to ischemia and reperfusion
Panel Physiology, Pathophysiology, Pharmacology and Endocrinology
Department or equivalent Heart Institute (University of Pécs)
Participants Cziráki, Attila
Fazekas, Levente
Gaszner, Balázs
Hejjel, László
Horváth, Iván Gábor
Lénárd, László
Simor, Tamás
Szokodi, István
Starting date 2003-01-01
Closing date 2007-12-31
Funding (in million HUF) 11.280
FTE (full time equivalent) 0.00
state closed project





 

Final report

  
Results in Hungarian
((1) A szívhipertrófiát irányító GATA-4 transzkripciós faktort a mitogén-aktiválta protein kinázok (p38, ERK) aktiválják mechanikai feszítés során. (2) Kamrai falfeszülés az endogén endothelin-1 és az angiotenzin II révén váltja ki a BNP expressziójának fokozódását. (3) Az endogén ouabain-szerű anyag szerepet játszik az ANP bal kamrai génexpressziójának szabályozásában. (4) A nukleáris faktor-kappaB transzkripciós faktor gátlása kivédi a bal kamrai remodellinget annak előrehaladott fázisában. (5) A szívizom-kontraktilitás szabályozásában döntő szerepet játszanak a mitogén aktiválta protein kinázok. (6) Viabilitás, coronária occlusios idő okozta bal kamra funkció változás vizsgálata MRI-vel. Az occlusios idő 45 és 90 perc között változtatvan proporcionálisan rontotta a bal kamra funkciót, mely mögött okként az arányos infarctus méret áll. (7) Humán mitrokondriumok nem termelnek relevans mennyiségű nitrogén oxidot iszkémiás szívbetegekben. (8) A flavonoid szupplementáció előnyös hatású krónikus obstruktív tüdőbetegségben. (9) Invazív módon validáltuk az artériás stifness meghatározására szolgáló non-invazív Arteriográf készüléket. (10) Jellemeztük a szérum asszimmetrikus dimetil-arginin változását katéteres revascularizatios eljáráson átesett betegeknél. (11) A poli-ADP-ribóz polimeráz enzim gátlása javítja a bal kamrai funkciót akut és krónikus experimentális szívelégtelenségben. (12) A szívritmus variabilitás vizsgálatára hatékony elemző rendszert fejlesztettünk ki.
Results in English
(1) Our results suggest that the prohypertrophic transcription factor GATA-4 is activated by mitogen-activated protein kinases (p38, ERK) in response to mechanical stretch. (2) Stretch-induced activation of B-type natriuretic peptid gene expression is regulated by endogenous endothelin-1 and angiotensin II. (3) Adrenal-derived endogenous ouabain-like compound is involved in the activation of atrial natriuretic peptide in the left ventricle. (4) Inhibition of nuclear factor kappa-B attenuates severe left ventricular remodeling. (5) Mitogen-activated protein kinases play pivotal role in the regulation of myocardial contractility. (6) MRI study of LV function: dependence on coronary occlusion time and viability. Occlusion time between 45 and 60 minutes induced larger infarct and consequent heart failure proportionally. (7) Human heart mitochondria do not produce physiologically relevant quantities of nitric oxide. (8) Dietary flavonoids are beneficial in chronic obstructive pulmonary disease. (9) A new, oscillometric, portable device for measuring augmentation index and aortic pulse wave velocity (Areteriograph) has been validated invasively. (10) The response of asymetric dimethylarginine levels to stent placement has been characterized in patients with coronary heart disease. (11) Inhibition of poly(ADP-ribose) polymerase improves cardiac function in acute and chronic heart failure. (12) A data analysis system has been developed for analysis of heart rate variability.
Full text http://real.mtak.hu/1060/
Decision
Yes





 

List of publications

  
P. SURANYI, P. Kiss, T. Simor, A. Elgavish and G.A. Elgavish: A: Combined Method for the Determination of Myocardial Perfusion in Experimental Animals Using Microspheres and MRI., Journal of Cardiovascular Magnetic Resonance; JCMR-6010-R2, 2006
Szokodi I, Kerkelä R, Kubin AM, Sármán B, Skoumal R, Papp L, Tóth M, Ruskoaho H: Functionally opposing roles of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase in the regulation of cardiac contractility, Circulation. 110(17 Suppl. III):III-108-III-108, 2004
Tenhunen O, Sármán B, Kerkela R, Szokodi I, Papp L, Tóth M, Ruskoaho H: Mitogen-activated protein kinases p38 and ERK 1/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart, J Biol Chem. 279(23):24852-24860, 2004
Sármán B, Skoumal R, Leskinen H, Ilves M, Soini Y, Pikkarainen S, Lakó-Futó Z, Papp L, Tóth M, Ruskoaho H, Szokodi I: Inhibition of nuclear factor-kappaB signaling attenuates angiotensin II-induced cardiac hypertrophy, remodeling, and apoptosis, Circulation. 110(17 Suppl. III):III-21-III-21, 2004
Hejjel L: Suppression of power-line interference by analog notch filtering in the ECG signal for heart rate variability analysis. To do or not to do?, Med Sci Monit. 10(1):MT6-MT13, 2004
Hejjel L, Roth E: What is the adequate sampling interval of the ECG signal for heart rate variability analysis in the time domain?, Physiol Meas. 25:1405-1411, 2004
Hejjel L, Kellenyi L: The corner frequencies of the ECG amplifier for heart rate variability analysis, Physiol Meas 26:39-47, 2005
Hejjel L: Reappraising technical aspects of the ECG recording for HRV analysis, ESH-BAVAR Congress Book. 37, 2004
Faludi R, Toth L, Poto L, Cziraki A, Simor T, Papp L: Relationship between B-type natriuretic peptide levels, conventional Doppler and tissue Doppler echocardiographic parameters in patients with hypertrophic cardiomyopathy., Eur J Echocardiogr. 1(Suppl.):S8., 2004
Komócsi A, Pintér T, Horváth IG: Raising the loading dose of clopidogrel, aiming the proper target?, Eur Heart J. 26(7):740, 2005
Papp E, Czopf L, Habon T, Halmosi R, Horvath B, Marton Z, Tahin T, Komocsi A, Horvath I, Melegh B, Toth K: Drug-induced myocardial infarction in young patients; Report of two cases, Int J Cardiol. 98(1):169-170, 2005
Hejjel L, Komócsi A, Kónyi A, Lénárd L, Imre J, Papp L: Az akut koronária szindrómáról 2004-ben., Cardiol Hung. 34:194-200., 2004
Komócsi A, Horváth IG, Papp L: Krónikus antikoagulálás otthoni ellenorzése., Cardiol Hung. 34: 136-141., 2004
Toth L, Simor T, Faludi R, Sepp R, Repa I, Papp L: Characterization of hypertrophic obstructive and non-obstructive cardiomyopathy using contrast agent enhanced cardiac MRI., J Cardiovasc Magn Reson. 1:298-299, 2004
Simor T, Toth L, Faludi R, Papp L, Repa I: Characterization of regional function in HCM using contrast agent enhanced cardiac MRI, J Cardiovasc Magn Reson. 1:301-302, 2004
Faludi R, Toth L, Poto L, Cziraki A, Simor T, Papp L: Correlation of B-type natriuretic peptide (NT-proBNP) levels and conventional and tissue Doppler echocardiographic parameters of left ventricular diastolic function in patients with hypertrophic cardiomyopathy, Orv Hetil. 146(1):23-6, 2005
Atlasz T, Kellenyi L, Kovacs P, Babai N, Thuroczy G, Hejjel L, Hernadi I: The application of surface plethysmography for heart rate variability analysis after GSM radiofrequency exposure, J Biochem Biophys Methods. 69(1-2):233-236, 2006
Piuhola J, Szokodi I, Ruskoaho H: Endothelin-1 and angiotensin II contribute to BNP but not c-fos gene expression response to elevated load in isolated mice hearts, Biochim Biophys Acta. 1772(3):338-344, 2007
Pacher P, Liaudet L, Mabley JG, Cziraki A, Hasko G, Szabo C: Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure., Int J Mol Med. 17(2):369-75, 2006
Simor T, Gaszner B, Oshinski JN, Waldrop SM, Pettigrew RI, Horvath IG, Hild G, Elgavish GA: Gd(ABE-DTTA)-enhanced cardiac MRI for the diagnosis of ischemic events in the heart, J Magn Reson Imaging 21(5):536-545., 2005
Tenhunen O, Szokodi I, Ruskoaho H: Posttranscriptional activation of BNP gene expression in response to increased left ventricular wall stress: role of calcineurin and PKC, Regul Pept. 128(3):187-196, 2005
Kovács I, Hejjel L, Gál I, Rőth E: Sequential changes of heart rate variability following laparoscopic or open cholecystectomy, Exp Clin Card. 11(3):256, 2006
Balaskó M, Soós Sz, Cziráki A, Sárszegi Zs, Papp L, Garai J, Szelényi Z: The benefit of dietary flavonoids in chronic obstructive pulmonary disease in manopausa, Eur Resp J. (under revision), 2007
Toth L, Simor T, Faludi R, Fodi E, Knausz M, Repa I, Papp L: Characterisation of asymmetric septal and apical hypertrophic cardiomyopathy using cardiac ceMRI, EURO CMR 2005, Zurich, Switzerland, 2005
Csordas A, Pankotai E, Snipes JA, Cselenyak A, Sarszegi Z, Cziraki A, Gaszner B, Papp L, Benko R, Kiss L, Kovacs E, Kollai M, Szabo C, Busija DW, Lacza Z: Human heart mitochondria do not produce physiologically relevant quantities of nitric oxide., Life Sci. 23;80(7):633-637, 2007
Cziráki A., Sárszegi Zs., Gaszner B.,Illyés M., Papp L.: A vaszkuláris endothel és a pulmonális epitel noninvazív vizsgálata iszkémiás szívbetegekben., Cardiol Hung. 35:A50, 2005
Miklán D., Keller J., Sárszegi Z., Gaszner B., Cziráki A., Papp L: Evaluation of mechanical arterial properties in patients with coronary vasoconstriction, Eur J Echocardiogr. 7:S120, 2006
Simor T, Tóth L, Horváth I, Tóth A, Tormási I, Hüttl K, Repa I, Papp L: Stressz perfúziós MR vizsgálat diagnosztikus értéke, Cardiol Hung. 35:A59, 2005
Tóth L, Faludi R, Knausz M, Simor T, Papp L: Nonkompakt kardiomiopátia, családleírás, irodalmi áttekintés, Cardiol Hung. 35:A86, 2005
Papp L, Király L, Hejjel L: Cardiac surgery - 2005, Orv Hetil. 146(20 Suppl 2):1099-1106, 2005
Faludi R, Toth L, Simor T, Papp L: NT-proBNP levels and left atrial volumes in patients with isolated left ventricular diastolic dysfunction., Eur J Heart Fail 4(Suppl. 1.):247, 2005
Faludi R, Toth L, Fodi E, Kolto G, Gyomorei B, Simor T, Papp L: Correlation between left ventricular mass and the parameters characterizing the left ventricular diastolic function in patients with hypertrophic cardiomyopathy, Eur J Echocardiogr. 6(Suppl. 1.)S107:720, 2005
Faludi R, Toth L, Gyomorei B, Kolto G, Simor T, Papp L: Assessment of diastolic function using tissue Doppler echocardiography: what is the normal value of the mitral annular early diastolic velocity (Ea)?, Eur J Echocardiogr 6(Suppl. 1.)S179:1115, 2005
Skoumal R, Szokodi I, Aro J, Földes G, Göőz M, Seres L, Sármán B, Lakó-Futó Z, Papp L, Vuolteenaho O, Leppäluoto J, deChâtel R, Ruskoaho H, Tóth M: Involvement of endogenous ouabain-like compound in the cardiac hypertrophic process in vivo, Life Sci. (in press), 2007
Sármán B, Skoumal R, Leskinen H, Rysä J, Ilves M, Soini Y, Tuukkanen J, Pikkarainen S, Lakó-Futó Z, Sármán B, Papp L, deChâtel R, Tóth M, Ruskoaho H, Szokodi I: Nuclear factor-kappaB signaling contributes to severe, but not moderete, angiotensin II-induced left ventricular remodeling, J Hypertens (under revision), 2007
Szokodi I, Kerkelä R, Kubin AM, Skoumal R, Sármán B, Pikkarainen S, Horváth IG, deChâtel R, Papp L, Tóth M, Ruskoaho H: Functionally opposing roles of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase in the regulation of cardiac contractility, Circulation (under revision), 2007
Horváth I, Cziráki A, Gaszner B, Sárszegi Zs, Papp L: Invasive validation of a new, oscillometric, portable device for measuring augmentation index, and aortic pulse wawe velocyty simultaneously: the Areteriograph, J Hypertension. (submitted), 2007
Ajtay Z, Cziráki A, Horváth I, Papp L, Sulyok E, Martens-Lobenhoffer J, Bode-Böger SM: The response of asymetric dimethylarginine levels to stent placement in patients with coronary heart disease, Hypertension. (submitted), 2007
Gasz B, Lenard L, Racz B, Benko L, Borsiczky B, Cserepes B, Gal J, Jancso G, Lantos J, Ghosh S, Szabados S, Papp L, Alotti N, Roth E: Effect of cardiopulmonary bypass on cytokine network and myocardial cytokine production, Clin Cardiol. 29(7):311-315, 2006
Tóth L, Faludi R, Fődi E, Knausz M, Repa I, Papp L, Simor T: A szív-MR vizsgálat jelentősége a hirtelen halál rizikójának felmérésében hipertrófiás kardiomiopátiás betegekben, Cardiol Hung. 36(Suppl.):A88, 2006
Tóth L, Faludi R, Fődi E, Knausz M, Varga-Szemes A, Papp L, Simor T: Evidence based, MRI strengthened risk stratification strategy for hypertrophic cardiomyopathy patients - A follow up study, Eur J Echocardiogr 1(Suppl.):S205, 2006
Faludi R, Tóth L: Letter to the Editor, Am Heart J, 152:e13, 2006
Faludi R, Tóth L, Fődi E, Költő Gy, Gyömörei B, Simor T, Papp L: Correlation between longitudinal systolic function of the left ventricle and the “non-velocity-type” parameters characterizing left ventricular diastolic function, Eur J Heart Fail 1(Suppl.):61, 2006
Faludi R., Tóth L., Fődi E., Gyömörei B., Költő Gy., Simor T., Papp L: Mely tényezők határozzák meg a bal pitvari volument hipertrófiás és dilatatív cardiomyopathiás betegekben?, Cardiol Hung. 36:A82, 2006
Tóth L, Varga-Szemes A, Faludi R, Tóth A, Papp L, Simor T: MRI study in isolated left ventricular noncompaction, J Cardiovasc Magn Reson. 9:406, 2007
Gasz B, Lenard L, Benko L, Borsiczky B, Szanto Z, Lantos J, Szabados S, Alotti N, Papp L, Roth E: Expression of CD97 and adhesion molecules on circulating leukocytes in patients undergoing coronary artery bypass surgery, Eur Surg Res. 37(5):281-289, 2005
P. SURANYI, P. Kiss, B. Ruzsics, B. C. Brott, T. Simor, A. Elgavish, R.A. Baker, N.H. Saab-Ismail, and G.A. Elgavish: In Vivo Myocardial Tissue Kinetics of Gd(ABE-DTTA), a Tissue-Persistent Contrast Agent., Magn Reson Med. MRM-05-8607.R1 (in press), 2006
Komócsi A, Simor T, Tóth L,Szabados S, Mágel F, Pintér T, Aradi D, Kónyi A, Horváth IG, Papp L.:: Magnetic resonance studies in management of adult cases with Bland-White-Garland syndrome, . Int J Cardiol. 2006 (in-press), 2006
P. SURANYI, P. Kiss, B. Ruzsics, B. C. Brott, T. Simor, G.A. Elgavish: Equilibrium Signal Intensity-Mapping, an MRI Method for Fast Mapping of Longitudinal Relaxation Rates and for Image Enhancement, J Magn Reson Imaging. 2006; Available Online (Elsevier, Science Direct, doi:10.1016/j.mri..10.008) (2006), 2006
Miklán D., Keller J., Sárszegi Z., Gaszner B., Cziráki A., Papp L: ction, Eur J Echocardiogr. 7:S120, 2006
Cziráki A., Gaszner B., Sárszegi Z., Horváth I., Illyés M., Papp L: Endothelial function in patients with ischaemic heart disease, Eur Heart J. 27:124, 2006
Suranyi P, Kiss P, Brott BC, Simor T, Elgavish A, Ruzsics B, Saab-Ismail NH, Elgavish GA: Percent infarct mapping: an R1-map-based CE-MRI method for determining myocardial viability distribution., Magn Reson Med.;56:535-45. (2006), 2006
Kiss P, Suranyi P, Simor T, Saab-Ismail NH, Elgavish A, Hejjel L, Elgavish GA: In vivo R1-enhancement mapping of canine myocardium using ceMRI with Gd(ABE-DTTA) in an acute ischemia-reperfusion model, J Magn Reson Imaging.;24:571-9. (2006), 2006
Ruzsics B, Suranyi P, Kiss P, Brott BC, Elgavish A, Saab-Ismail NH, Simor T, Elgavish GA.: Gd(ABE-DTTA), a novel contrast agent, at the MRI-effective dose shows absence of deleterious physiological effects in dogs., Pharmacology.;77:188-94. Epub 2006 Jul 27. (2006), 2006
Vertesaljai M, Piroth Z, Fontos G, Toth A, Simor T, Lueff S, Remenyi P, Reti M, Masszi T, Andreka P.: [Experiences with the first, Hungarian autologous bone marrow cell transplantation in acute myocardial infarction], Orv Hetil. Jan 8;147(1):3-6 (2006), 2006



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