Lipidmembrance school at the Biological Research Center  Page description

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Details of project

  
Identifier
44836
Type NI
Principal investigator Vígh, László
Title in Hungarian Lipid-membrán iskola a Szegedi Biológiai Központban
Title in English Lipidmembrance school at the Biological Research Center
Panel Molecular and Structural Biology and Biochemistry
Department or equivalent Institute of Biochemistry (HUN-REN Biological Research Centre Szeged)
Participants Balogh, Gábor
Balogi, Zsolt
Bereczki, Erika
Boros, Imre Miklós
Csabai, Péter
Debreczeny, Mónika
Glatz, Attila
Gwendolyn C., Barcelo
Gyorfy, Zsuzsanna
Hőgyes, Endre
Horváth, Ibolya
Joó, Ferenc
Kitajka, Klára
Klement, Éva
Medzihradszky, Katalin
Nagy, Eniko
Novákné dr. Papp, Éva
Papp, Gábor
Penke, Botond
Puskás, László
Sántha, Miklós
Shigapova, Natalia
Török, Zsolt
Zvara, Ágnes
Starting date 2003-01-01
Closing date 2005-12-31
Funding (in million HUF) 87.300
FTE (full time equivalent) 0.00
state closed project





 

Final report

  
Results in Hungarian
Tisztelegve az elhúnyt Farkas Tibor akadémikus emlékének, a Lipid-Membán Iskola a Szegedi Biológiai Központban minden tekintetben végrehajtotta a pályázatban tervezett feladatait, teljesítette misszióját. Képes volt a meglévő tudás valamint eszközállomány összefogására, koncentrált és hatékony kihasználására. A közös munka eredményeképpen számos, stratégiailag igen jelentős fejlesztés vált lehetővé. Nagy számú új, eredeti tudományos eredmény (köztük több review, ill. könyv) publikációjára került ill. kerül még sor a program lezárását követően . Törekvéseink fénypontját jelzik az egymolekula követésére alkalmas mikroszkópiás laboratórium (nanotechnológiai alapú membrán kutatóhely, SzBK) ill. az első hazai lipidomikai vertikum (SzTE, SzBK ) teljes kiépítése. Kiemelendő, hogy a program célkitűzésének megfelelően a kutatásba számos hallgatót vontunk be.Szakdolgozatok ill. PhD disszertációk születtek a pályázat támogatásával. Aktivitásunk egyértelmű nemzetközi elismeréseképpen 2006-ban Magyarországon kerül megrendezésre a Nemzetközi Lipidtudományi Konferencia (ICBL) kollégáink rendezésében, Vígh László elnökletével. A Lipid-Membrán Iskola szegedi résztvevői az alap- és alkalmazott lipid és membrán kutatási eredményeik, valamint a kiépült együttműködéseik alapján sikeresen részévé váltak a Dél-Alföldi Neurobiológiai Tudásközpontnak.
Results in English
Saluting to the memory of late Tibor Farkas, the Lipid-Membrane School in the Szeged Biological Research Center successfully accomplished its major goals and fulfilled its mission. The school became capable for bringing together the preexisting knowledges and resources, by effectively concentrate and exploit them. As a result of the common and complementary efforts, several highly important and ambicious projects have been implemented. As a result of these, high number of new, original publications, reviews indicated the success. Amongst of our most remarkable achievements, we should mention the foundation of the nanotech based single molecule microscopy technique, allowing the real-time monitoring of most various lipid-membrane events (BRC). We are also proud, that the first Hungarian lipidomics lab can start soon its operation (SzTE, BRC). Several students participated in our activity: prepared diploma work and PhD thesis. Best highlighting our successful activity, our colleaques will organize the next International Congress of Lipid Sciences (ICBL), chaired by Laszlo Vigh. Based on their basic and applied research related activities and cooperation, most of the participants of the peresently terminated Szeged Lipid-Membrane School have joined successfully the Szeged Neurobiological Knowledge Center.
Full text http://real.mtak.hu/1247/
Decision
Yes





 

List of publications

  
Enünlü I;: Functional investigation of an RNA-binding protein with methyltransferase domain, Ph.D. Thesis Szeged University, 2003
Enunlu I; Papai G; Cserpan I; Udvardy A; Jeang KT; Boros I.:: Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus, Biochem Bioph Res Co 309:44-51, 2003
Pápai G;: A Drosophila melanogaster dtl es ada2a/rpb4 génjeinek szerkezeti és funkcionális vizsgálata, Ph.D. tézis, Szegedi Egyetem, 2005
Letoha T; Somlai C; Takacs T; Szabolcs A; Jarmay K; Rakonczay Z Jr; Hegyi P; Varga I; Kaszaki J; Krizbai I; Boros I; Duda E; Kusz E; Penke B.:: A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis, World J Gastroenetrol 11: 990-999, 2005
Rakonczay Z; Takacs T; Boros I; Lonovics J.:: Heat shock proteins and the pancreas, J Cell Physiol 195:383-391, 2003
Balogi Z; Török Z; Balogh G; Jósvay K; Shigapova N; Vierling E; Vígh L; Horváth I.: ''Heat shock lipid'' in cyanobacteria during heat/light-acclimation., Arch. Biochem. Biophys. 436: 346-354, 2005
Shigapova N; Torok Z; Balogh G; Goloubinoff P; Vigh L; Horvath I.: Membrane fluidization triggers membrane remodeling which affects the thermotolerance in Escherichia coli., Biochem Biophys Res Commun. 328:1216-23., 2005
Puskas LG; Bereczki E; Santha M; Vigh L; Csanadi G; Spener F; Ferdinandy P; Onochy A; Kitajka K.: Cholesterol and cholesterol plus DHA diet-induced gene expression and fatty acid changes in mouse eye and brain., Biochimie.86:817-24., 2004
Kitajka K; Sinclair AJ; Weisinger RS; Weisinger HS; Mathai M; Jayasooriya AP; Halver JE; Puskas LG.: Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression., Proc Natl Acad Sci U S A. 101:10931-6, 2004
Kalman J; Juhasz A; Rakonczay Z; Abraham G; Zana M; Boda K; Farkas T; Penke: Increased serum butyrylcholinesterase activity in type IIb hyperlipidaemic patients, Life Sci. 75:1195-204., 2004
Kalman J; Juhasz A; Janka Z; Rakonczay Z; Abraham G; Boda K; Farkas T; Penke: Serum butyrylcholinesterase activity in hyperlipidaemia, Atherosclerosis. 173:145-6, 2004
Csabai P; Joó F: Synthesis and Catalytic properties of New Water-Soluble Ruthenium(II) –N-Heterocyclic Carbene Complexes, Organometallics 23: 5640-5643, 2004
Hunyadi-Gulyás É; Medzihradszky KF.: Factors that contribute to the complexity of protein digests., Drug Discovery Today: Targets 3:S3-S10, 2004
Glatz A; Horváth I; Török Zs; Vígh L: A membránok és a chaperonok szerepe a hőstressz érzékelésében és elhárításában., közlésre elfogadva: Botanikai Közl., 2004
Balogh G; Horváth I; Nagy E; Török Z; Parasassi T; Vígh L.: Rapid plasma membrane reorganisation in response to heat and membrane perturbation, Chem. Phys. Lipids 130: 46, 2004
Horváth I; Glatz A; Balogi Z; Balogh G; Puskás LG; Jósvai K; Liberek K; Debreczeny M; Hunyadi-Gulyás É; Medzihradszky KF; Goloubinoff P; Vígh L: The emerging role for small heat shock proteins in the regulation of composition and dynamics of cell membranes, Chem. Phys. Lipids 130: 29, 2004
Hargitai J; Lewis H; Boros I; Racz T; Fiser A; Kurucz I; Benjamin I; Vigh L; Penzes Z; Csermely P; Latchman DS.: Bimoclomol; a heat shock protein co-inducer; acts by the prolonged activation of heat shock factor-1., Biochem Biophys Res Commun. 307:689-95., 2003
Vereb G; Szollosi J; Matko J; Nagy P; Farkas T; Vigh L; Matyus L; Waldmann TA; Damjanovich S.: Dynamic; yet structured: The cell membrane three decades after the Singer-Nicolson model, Proc Natl Acad Sci U S A. 100:8053-8, 2003
de Wilde MC; Hogyes E; Kiliaan AJ; Farkas T; Luiten PG; Farkas E.: Dietary fatty acids alter blood pressure, behavior and brain membrane composition of hypertensive rats., Brain Res. 988:9-19., 2003
Barcelo-Coblijn G; Hogyes E; Kitajka K; Puskas LG; Zvara A; Hackler L Jr;: Modification by docosahexaenoic acid of age-induced alterations in gene expression and molecular composition of rat brain phospholipids, Proc Natl Acad Sci U S A. 100:11321-6., 2003
Hogyes E; Nyakas C; Kiliaan A; Farkas T; Penke B; Luiten PG.: Neuroprotective effect of developmental docosahexaenoic acid supplement against excitotoxic brain damage in infant rats, Neuroscience. 119:999-1012, 2003
Barcelo-Coblijn G; Kitajka K; Puskas LG; Hogyes E; Zvara A; Hackler L Jr; Farkas T.: Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio., Biochim Biophys Acta. 1632:72-9., 2003
Sümegi M.; Hunyadi-Gulyás É; Medzihradszky KF; Udvardy A.: 26S proteasome subunits are O-linked N-acetylglucosamine-modified in Drosophila melanogaster., Biochem. Biophys. Res. Com. 312:1284-1289, 2003
Horváth HH; Joó F.:: Stereoselective homogeneous catalytic hydrogenation of disubstituted alkynes in aqueous-organic biphasic media, Reaction Kinetics and Catalysis Letters 85:355-360, 2005
de Marco A; Vígh L; Diamant S; Goloubinoff P.:: Native folding of aggregation-prone recombinant proteins in Escherichia coli by osmolytes, plasmid- or benzyl alcohol-overexpressed molecular chaperones., Cell Stress Chaperon 10:329-339, 2005
Vígh L; Escriba PV; Sonnleitner A; Sonnleitner M; Piotto O; Maresca B; Horváth I; Harwood JL.:: The significance of lipid composition for membrane activity: New concepts and ways of assessing function.,, Prog Lipid Res. 44:303-344, 2005
Balogh G; Horváth I; Nagy E; Hoyk Zs; Benkő S; Bensaude O; Vígh L.: The hyperfluidizatin of mammalian cell membranes acts as a signal to initiate the heat shock protein response, FEBS J 272:6077-6086, 2005
Pankotai T; Komonyi O; Bodai L; Ujfaludi Zs; Muratoglu S; Tora, L; Szabad J; Boros I.:: The homologous Drosophila transcriptional adaptors ADA2 a and ADA2b are both required for normal development, but have different functions., Mol Cell Biol 18: 8215-27, 2005
Letoha T; Somlai Cs; Takacs T; Szabolcs A; Jármay K; Rakonczay Z; Hegyi P; Varga I; Kaszaki J; Krizbai I; Boros I; Duda E; Kusz E; Penke B.:: The proteasome inhibitor MG132 protects against acute pancreatitis., Free Radic. Biol. Med. 39:1142-1151, 2005
Papai G; Komonyi O; Toth Z; Pankotai T; Muratoglu S; Udvardy A; Boros I.:: Intimate relationship between the genes of two transcriptional coactivators, ADA2a and PIMT, of Drosophila, Gene 348: 13-23, 2005
Komonyi O; Papai G; Enunlu I; Muratoglu S; Pankotai T; Kopitova D; Maroy P; Udvardy A; Boros I.:: DTL, the Drosophila homolog of PIMT/Tgs1 nuclear receptor coactivator-interacting protein/RNA methyltransferase, has an essential role in development, J Biol Chem, 280:12397-12404, 2005
Muratoglu S; Georgleva S; Papai G; Scheer E; Enunlu I; Komonyi O; Cserpan I; Lebedeva L; Nabirochkina E; Udvardy A; Tora L; Boros I.:: Two different Drosophila ADA2 homologues are present in distinct GCN5 histone acetyltransferase-containing complexes, Mol Cell Biol 23: 306-321, 2003
Rakonczay Z;Duda E; Kaszaki J; Ivanyi B; Boros I; Lonovics J; Takacs T.:: The anti-inflammatory effect of methylprednisolone occurs down- stream of nuclear factor-kappa B DNA binding in acute pancreatitis, Eur J Pharmacol 464:217-227, 2003
Rakonczay Z; Jarmay K; Kaszaki J; Mandi Y; Duda E; Hegyi P; Boros I; Lonovics J; Takacs T.:: NF-kappa B activation is detrimental in arginine-induced acute pancreatitis, Free Radical Bio Med 34:696-709, 2003
Rakonczay Z; Boros I; Jarmay K; Hegyi P; Lonovics J; Takacs T.:: Ethanol administration generates oxidative stress in the pancreas and liver, but fails to induce heat-shock proteins in rats, J Gastroen Hepatol 18: 858-867, 2003
Papp G; Horváth H; Kathó Á; Joó F.:: Synthesis and solution equilibria of trisodium carbonylchlorotris[3-(diphenylphosphino-P)benzenesulfonato]-hydridoruthenate(3-) ([RuH(Cl)(CO){m-(Ph2P)-C6H4-SO3Na}3]) and trisodium aquacarbonyltris[3-(diphenylphosphino-P)benzenesulfonato]-hydridoruthenate(2-) Tetra, Helvetica Chimica Acta 88: 566-573, 2005
Horváth HH; Joó F.:: Selective catalytic hydrogenation of disubstituted alkynes, 16th FECHEM Conf. Organometal. Chem Book of Abstracts, p. 188, 2005
Horváth HH; Joó F.:: Selective hydrogenation of alkynes in aqueous-organic biphasic systems, Int. Conf. on Knowledge-based Materials and Technologies for Sustainable Chemistry (Tallinn, Estonia, 2005) Book of Abstracts, p.89, 2005
Medzihradszky KF.:: Peptide sequence analysis, Methods Enzymol 402:209-44, 2005
Jayasooriya AP; Ackland ML; Mathai ML; Sinclair AJ; Weisinger HS; Weisinger RS; Halver JE; Kitajka K; Puskas LG.:: Perinatal omega-3 polyunsaturated fatty acid supply modifies brain zinc homeostasis during adulthood, Proc Natl Acad Sci U S A 102:7133-7138, 2005
Puskas LG; Kitajka K; Sinclair AJ.:: Regulation of genetic information by omega 3 fatty acids, British Journal of Nutrition Society (in press), 2006



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