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Structure, transport mechanism, physiological role and subcellular localization of five lipid transporters (ABCC6, ABCG5, ABCG8, ABCG1 és ABCG4).
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List of publications |
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Aranyi T, Varadi A, Simon I, Tusnady GE.: The BiSearch web server., BMC Bioinformatics 7:431, 2006, 2006 | Muller M, Klein I, Kopacsi S, Remaley AT, Rajnavolgyi E, Sarkadi B, Varadi A.: Co-expression of human ABCG5 and ABCG8 in insect cells generates an androstan stimulated membrane ATPase activity., FEBS Lett. 580 6139-44, 2006, 2006 | Tusnady GE, Sarkadi B, Simon I, Varadi A.: Membrane topology of human ABC proteins, FEBS Lett. 580:1017-22. 2006, 2006 | Sarkadi B, Homolya L, Szakacs G, Varadi A.: Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system., Physiol Rev. 86:1179-236, 2006, 2006 | Cervenak J, Andrikovics H, Ozvegy-Laczka C, Tordai A, Nemet K, Varadi A, Sarkadi B: The role of the human ABCG2 multidrug transporter and its variants in cancer therapy and toxicology, Cancer Lett. 234: 62-72, 2006, 2006 | Ozvegy-Laczka C, Koblos G, Sarkadi B, Varadi A.: Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition, BBA Biomembranes 1668:53-63, 2005, 2005 | Ozvegy-Laczka C, Varady G, Koblos G, Ujhelly O, Cervenak J, Schuetz JD, Sorrentino BP, Koomen GJ, Varadi A, Nemet K, Sarkadi B.: Function-dependent conformational changes of the ABCG2 multidrug transporter modify its interaction with a monoclonal antibody on the cell surface., J Biol Chem. 280: 4219-27, 2006, 2005 | Telbisz A, Müller M, Ozvegy-Laczka C, Homolya L, Szente L, Váradi A, Sarkadi B.:: Membrane cholesterol selectively modulates the activity of the human ABCG2 multidrug transporter, Biochim Biophys Acta. Biomembranes 1768: 2698-713, 2007 | Szakács,G, Homolya, L, Váradi A, Sarkadi B.:: MDR-ABC Transporters, Encyclopedia of Molecular Pharmacology, 2007 | Ozvegy-Laczka C, Laczkó R, Hegedus C, Litman T, Várady G, Goda K, Hegedus T, Dokholyan NV, Sorrentino BP, Váradi A and Sarkadi B:: Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter, J Biol Chem.283, 26059-70, 2008 | Symmons O, Váradi A and Arányi T: How segmental duplications shape our genome: recent evolution of ABCC6 and PKD1 Mendelian disease genes, Mol Biol Evol 25, 2601-13, 2008 | Szakács G, Váradi A, Ozvegy-Laczka C and Sarkadi B: The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox),, Drug Deliv.Today 13, 379-393, 2008 | Szeri F, Iliás A, Pomozi V, Robinow S, Bakos E and Váradi A: The high turnover Drosophila multidrug resistance-associated protein shares the biochemical features of its human orthologues, Biochim Biophys Acta.Biomembranes 2008 Nov 20, 2008 epub, 2008 | Li Q, Jiang Q, Pfendner E, Váradi A and Uitto J: Pseudoxanthoma elasticum: clinical phenotypes, molecular genetics and putative pathomechanisms, Exp Dermatol. 18 :1-11, 2009 | Fülöp K, Barna L, Symmons O, Závodszky P, Váradi A: Clustering of disease-causing mutations on the domain-domain interfaces of ABCC6, Biochem Biophys Res Commun 379: 706-9. Epub 2009 Jan 6, 2009 | Bors A, Ribiczey P, Köblös G, Brózik A, Ujfaludi Z, Magócsi M, Váradi A, Tordai A, Kovács T, Arányi T.: External cell control polymerase chain reaction: replacing internal standards with an unbiased strategy for quantitative polymerase chain reaction normalization., Anal Biochem. 372(2):261-3., 2008 | Elkind, N.B., Szentpétery, Z., Apáti, A., Özvegy-Laczka, C. Várady, G., Ujhelly, O., Szabó, K., Homolya, L., Váradi, A., Buday, L., Kéri, G., Német, K., Sarkadi, B.:: The multidrug transporter ABCG2 prevents tumor cell death induced by the EGF receptor inhibitor Iressa (ZD1839, Gefitinib)., Cancer Research, 65, 1770-1777, 2005 | Cortés-Selva F, Muñoz-Martínez F, Iliás A, Jiménez AI, Váradi A, Gamarro F, Castanys S.: Functional expression of a multidrug P-glycoprotein transporter of Leishmania, Biochem Biophys Res Commun. 329(2):502-7, 2005 | Tusnády GE, Simon I, Váradi A, Arányi T.: BiSearch: primer-design and search tool for PCR on bisulfite-treated genomes, Nucleic Acids Res. 2005 Jan 13;33(1):e9., 2005 | Arányi T, Ratajewski M, Bardóczy V, Pulaski L, Bors A, Tordai A, Váradi A.: Identification of a DNA methylation-dependent activator sequence in the pseudoxanthoma elasticum gene, ABCC6, J Biol Chem. 280:18643-50., 2005 |
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