Complex laminar electrophysological and histological examination of the human neocortical and hippocampal epilepsies  Page description

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Details of project

 
Identifier
49122
Type K
Principal investigator Ulbert, István
Title in Hungarian A neokortikális és hippocampális epilepsziák komplex elektrofiziológiai rétegelvezetéses és szövettani vizsgálata emberben
Title in English Complex laminar electrophysological and histological examination of the human neocortical and hippocampal epilepsies
Panel Neurosciences
Department or equivalent Institute for Psychology, HAS
Participants Czirják, Sándor
Erőss, Loránd
Fabó, Dániel
Fogarasi, András
Halász, Péter
Karmos, György
Maglóczky, Zsófia
Vajda, János
Starting date 2005-01-01
Closing date 2009-12-31
Funding (in million HUF) 13.260
FTE (full time equivalent) 8.35
state closed project





 

Final report

 
Results in Hungarian
Az OITI és a MTA PKI együttműködésében részletesen kidolgoztuk az intraoperatív és krónikus multielektróda beültetés technikai feltételeit és a vizsgálatok forgatókönyvét. Létrehoztunk egy kombinált multielektródás és konvencionális klinikai grid-sztrip elektródos elvezető rendszert, mely segítségével az operáció alatt, illetve krónikusan tudunk elvezetni intrahippokampális, intrakortikális, valamint szubdurális potenciálokat. Kimutattuk a szubikulumban generált különféle epilepsziás kisülések és a laterális temporális kéreg aktivitásának kapcsolatait, kimutattuk továbbá az alvásban és epilepsziában fontos K-komplexum generátorainak kérgi eredetét. Vizsgáltuk az alvási oszcilláció és az epilepsziás események kapcsolatát, kimutattuk, hogy epilepsziás emberben a felszínhez közeli kérgi rétegek igen erős szinaptikus és tüzelési aktivitást mutatnak az alvási oszcilláció aktív fázisában. Kimutattuk továbbá, hogy az aktív fázis csoportosítja az epilepsziás kisüléseket. A kérgi elektromos ingerlés hatását vizsgálva epilepsziás betegeken megállapítottuk, hogy a rövid elektromos ingerek inaktiválják a kérget, amit későbbiekben terápiás céllal lehet hasznosítani.
Results in English
In collaboration with the OITI and MTA PKI we have worked out in details the intraoperative and chronic multielectrode implantation technique and the schedule of the investigation. We have established a combined system composed of the conventional clinical grid and strip based electrophysiology apparatus and the novel investigational multielectrode system to measure intrahippocampal, intracortical and subdural potentials chronically and intraoperatively. We have shown the relationship of the subicular and lateral temporal lobe epileptic discharges, we have also shown the cortical origin of the K-complex, an important brain wave in sleep and epilepsy. We have investigated the slow sleep oscillation and its relationship to epilepsy. The slow waves were originated in the superficial layers of the cortex and the epileptiform discharges were grouped by the up-states of the slow oscillation. Investigating the effect of electrical stimulation, we have shown that brief current pulses can inactivate the cortex, which effect can also be exploited in the therapy of epilepsy.
Full text https://www.otka-palyazat.hu/download.php?type=zarobeszamolo&projektid=49122
Decision
Yes





 

List of publications

 
Cash SS, Halgren E, Dehghani N, Rossetti AO, Thesen T, Wang C, Devinsky O, Kuzniecky R, Doyle W, Madsen J, Bromfield E, Erőss L, Halász P, Karmos G, Csercsa R, Wittner L, Ulbert I.: The human K-complex represents an isolated cortical down-state., Science 2009 May 22;324(5930):1084-7., 2009
Wittner L, Huberfeld G, Clémenceau S, Eross L, Dezamis E, Entz L, Ulbert I, Baulac M, Freund TF, Maglóczky Z, Miles R.: The epileptic human hippocampal cornu ammonis 2 region generates spontaneous interictal-like activity in vitro., Brain. 2009 Nov;132(Pt 11):3032-46. Epub 2009 Sep 18., 2009
Steinvorth S, Wang C, Ulbert I, Schomer D, Halgren E.: Human entorhinal gamma and theta oscillations selective for remote autobiographical memory., Hippocampus. 2009 Mar 31. [Epub ahead of print], 2009
Schachter SC, Guttag J, Schiff SJ, Schomer DL; Summit Contributors (Ulbert I): Advances in the application of technology to epilepsy: the CIMIT/NIO Epilepsy Innovation Summit., Epilepsy & Behavior 2009 Sep;16(1):3-46., 2009
Kelemen A, Fogarasi A, Borbély C, Szűcs A, Fabó D, Jakus R, Rásonyi G, Halász P.: Nonmanipulative proximal upper extremity automatisms lateralize contralaterally in temporal lobe epilepsy., Epilepsia. 2009 Sep 22. [Epub ahead of print], 2009
Erõss L, Bagó AG, Entz L, Fabó D, Halász P, Balogh A, Fedorcsák I.: Neuronavigation and fluoroscopy-assisted subdural strip electrode positioning: a simple method to increase intraoperative accuracy of strip localization in epilepsy surgery., J Neurosurg. 2009 Feb;110(2):327-31., 2009
Eross L, Entz L, Fabó D, Jakus R, Szucs A, Rásonyi G, Kelemen A, Barcs G, Juhos V, Balogh A, Barsi P, Clemens Z, Halász P.: Interhemispheric propagation of seizures in mesial temporal lobe epilepsy., Ideggyogy Sz. 2009 Sep 30;62(9-10):319-25., 2009
Fabo D, Magloczky Z, Wittner L, Pek A, Eross L, Czirjak S, Vajda J, Solyom A, Rasonyi G, Szucs A, Kelemen A, Juhos V, Grand L, Dombovari B, Halasz P, Freund TF, Halgren E, Karmos G, Ulbert I: Properties of in vivo interictal spike generation in the human subiculum., BRAIN 131:(Pt 2) 485-499 (2008), 2008
Huberfeld G, Clemenceau S, Cohen I, Pallud J, Wittner L, Navarro V, Baulac M, Miles R.: Epileptiform activities generated in vitro by human temporal lobe tissue., Neurochirurgie. 2008 May;54(3):148-58., 2008
Molnar M, Csuhaj R, Gaal ZA, Czigler B, Ulbert I, Boha R, Kondakor I: Spectral characteristics and linear-nonlinear synchronization changes of different EEG frequency bands during the CNV., PSYCHOPHYSIOLOGY 45:(3) 412-419 (2008), 2008
Knake S, Wang CM, Ulbert I, Schomer DL, Halgren E.: Specific increase of human entorhinal population synaptic and neuronal activity during retrieval., Neuroimage. 2007 Aug 15;37(2):618-22., 2007
Einevoll GT, Pettersen KH, Devor A, Ulbert I, Halgren E, Dale AM.: Laminar population analysis: estimating firing rates and evoked synaptic activity from multielectrode recordings in rat barrel cortex., J Neurophysiol. 2007 Mar;97(3):2174-90., 2007
Pettersen KH, Devor A, Ulbert I, Dale AM, Einevoll GT.: Current-source density estimation based on inversion of electrostatic forward solution: effects of finite extent of neuronal activity and conductivity discontinuities., J Neurosci Methods. 2006 Jun 30;154(1-2):116-33., 2006
Haslinger R, Ulbert I, Moore CI, Brown EN, Devor A.: Analysis of LFP phase predicts sensory response of barrel cortex., J Neurophysiol. 2006 Sep;96(3):1658-63., 2006
Halgren E, Wang C, Schomer DL, Knake S, Marinkovic K, Wu J, Ulbert I.: Processing stages underlying word recognition in the anteroventral temporal lobe., Neuroimage. 2006 May 1;30(4):1401-13., 2006
Clemens Z, Fabo D, Halasz P.: Twenty-four hours retention of visuospatial memory correlates with the number of parietal sleep spindles., Neurosci Lett. 2006 Jul 31;403(1-2):52-6., 2006
Wang C, Ulbert I, Schomer DL, Marinkovic K, Halgren E.: Responses of human anterior cingulate cortex microdomains to error detection, conflict monitoring, stimulus-response mapping, familiarity, and orienting., J Neurosci. 2005 Jan 19;25(3):604-13., 2005
Lakatos P, Shah AS, Knuth KH, Ulbert I, Karmos G, Schroeder CE.: An oscillatory hierarchy controlling neuronal excitability and stimulus processing in the auditory cortex., J Neurophysiol. 2005 Sep;94(3):1904-11., 2005
Somogyvari Z, Zalanyi L, Ulbert I, Erdi P.: Model-based source localization of extracellular action potentials., J Neurosci Methods. 2005 Sep 30;147(2):126-37., 2005
Fabó Dániel, Maglóczky Zsófia, Erőss Loránd, Vajda János, Freund F. Tamás, Halász Péter, Karmos György, Ulbert István.: Subiculum-temporal cortex interactions during spikes and seizure., MITT 2005, A Magyar Idegtudományi Társaság 11. Kongresszusa, Pécs, 2005, 2005
E. Halgren, C. Wang, D.L. Schomer, J.R. Madsen, K. Marinkovic, I. Ulbert.: Theta generation in the human cortex., Program No. 774.13. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online., 2005
Ulbert I, Fabo D, Magloczky Z, Bognar L, Eross L, Halgren E, Freund TF, Halasz P, Karmos G.: Intracortical activation sequence of spontaneous and evoked spike-wave complexes in humans., Epilepsia 46: 200-200 Suppl. 6, 2005., 2005
Wang CM, Ulbert I, Doyle WK, Devinsky O, Kuzniecky R, Halgren E.: Spatio-temporal stages in word processing: Intracranial-recorded potentials and current source density in the human frontal, temporal and occipital cortices., Epilepsia 46: 323-323 Suppl. 8, 2005., 2005
Fabo D, Magloczky Z, Eross L, Freund TF, Halasz P, Karmos G, Ulbert I.: Subiculum-temporal cortex interactions during spikes and seizure., Epilepsia 46: 220-220 Suppl. 6, 2005., 2005
G. Karmos, L. Eross, D. Fabo, P. Halasz, E. Halgren, I. Ulbert.: Intracortical patterns of slow-sleep oscillations in humans., Program No. 308.18. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online., 2005
S.S. Cash, I. Ulbert, O. Devinksy, W. Doyle, E. Bromfield, J. Madsen, A. Cole, E. Halgren.: Time-frequency analysis of interictal discharges recorded with laminar microelectrodes in human neocortical epilepsy., Program No. 357.8. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online., 2005
Ulbert István, Karmos György.: Neural microprobes for cortical investigations., MITT 2005, A Magyar Idegtudományi Társaság 11. Kongresszusa, Pécs, 2005, 2005
Fabó D., Erőss L., Czirják S., Vajda J., Halász P.,Ulbert I.: Rétegelvezetések emberi hippocampalis formációból., A Magyar EEG Társaság 42. kongresszusa, Gyula, 2005., 2005
I. Ulbert, E. Halgren, G. Karmos.: Theta generation and modulation in the human cortex during word recognition., A Magyar EEG Társaság 42. kongresszusa, Gyula, 2005., 2005
Kelemen A, Rasonyi G, Szucs A, Fabo D, Halasz P.: Predictive factors of temporal lobe surgery., Ideggyogy Sz. 2006 Sep 20;59(9-10):353-9., 2006
Slezia A., Ulbert I., Bokor H., Csercsa R., Magony A., Acsady L.: Timing of higher order thalamic relays by extrareticular GABAergic afferents., FENS Abstr., vol.3, A003.22, 2006, 2006
Fabó D., Maglóczky Z., Erőss L., Freund F. T., Halász P., Karmos G., Ulbert I.: Spatiotemporal properties of interictal activity in the epileptic human subiculum., FENS Abstr., vol.3, A024.11, 2006, 2006
Csercsa R., Fabo D., Magony A., Eross L., Halasz P., Karmos G., Ulbert I.: Intracortical mechanisms of K-complex in human., FENS Abstr., vol.3, A042.8, 2006, 2006
Grand L., Dombovari B., Boldizsar E., Karmos G., Ulbert I.: Cortical gating of auditory information processing in sleep., FENS Abstr., vol.3, A073.6, 2006, 2006
Ulbert I., Csercsa R., Grand L., Boldizsar E., Magony A., Dombovari B., Karmos G.: Evoked "up" states in the cat auditory cortex., FENS Abstr., vol.3, A073.19, 2006, 2006
Ulbert I.: Relationship of the cortical slow oscillation and interictal spikes in epileptic patients., Magyar Epilepszia Liga Tudományos Ülése, Pécs, 2006. május., 2006
Fabó D.: Automatic seizure and spike detection., Magyar Epilepszia Liga Munkakonferencia, Győr, 2006. október., 2006
P. Blomquist, U. G. Indahl, A. Devor, I. Ulbert, G. T. Einevoll, A. M. Dale: Estimation of cortical microcircuit model from joint thalamic single-unit and cortical laminar-electrode recordings in rat whisker-barrel system., Program No.: 53.23/O15. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience., 2006
I. Ulbert, L. Grand, B. Dombovari, R. Csercsa, A. Magony, E. Boldizsar, G. Karmos: Evoked cortical hyperpolarization controls auditory information processing in natural non-REM sleep., Program No.: 239.1/G5. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience., 2006
S. S. Cash, N. Meng, C. Melinosky, I. Ulbert, O. Devinsky, A. Mehta, C. Wang, W. Doyle, E. Bromfield, J. Madsen, E. Halgren: Spatio-temporal evolution of focal seizures in humans recorded with macroelectrodes and laminar microelectrodes., Program No.: 313.2. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience., 2006
E. Halgren, S. S. Cash, N. Dehghani, A. Rossetti, R. Csercsa, D. Fabo, A. Magony, L. Eross, G. Karmos, P. Halasz, J. Madsen, I. Ulbert: Laminar analysis of evoked and spontaneous K-complexes in human., Program No.: 539.11/L13. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience., 2006
L. WITTNER, HUBERFELD, S. CLEMENCEAU, L. EROSS, E. DEZAMIS, M. BAULAC, I. ULBERT, R. MILES3, G. KARMOS.: The human hippocampal CA2 region generates spontaneous interictal like activity in vitro., Neuroscience Meeting Planner 259.5/Q13. San Diego, CA: Society for Neuroscience, 2007. Online., 2007
L. ENTZ, D. FABO, L. EROSS, P. HALASZ, L. WITTNER, G. KARMOS, E. HALGREN, I. ULBERT.: Inhibitory effects of cortical electrical stimulation in epileptic patients., Neuroscience Meeting Planner 259.13/Q20. San Diego, CA: Society for Neuroscience, 2007. Online., 2007
S. S. CASH, N. DEGHANI, I. ULBERT, T. THESEN, O. DEVINSKY, W. DOYLE, C. WANG, E. BROMFIELD, A. ROSSETTI, J. R. MADSEN, E. HALGREN.: Neural generators of sleep spindles in humans inferred from microelectrode array recordings., Neuroscience Meeting Planner 791.7/K7. San Diego, CA: Society for Neuroscience, 2007. Online., 2007
N. F. MENG, E. HALGREN, I. ULBERT, O. DEVINSKY, W. DOYLE, A. MEHTA, C. WANG, T. THESEN, E. BROMFIELD, J. R. MADSEN, S. S. CASH.: Intracolumnar generators of human alpha rhythms., Neuroscience Meeting Planner 791.8/K8. San Diego, CA: Society for Neuroscience, 2007. Online., 2007
J. F. Bartscher, I. Ulbert, O. Devinsky, W. Doyle, E. B. Bromfield, J. Madsen, E. Halgren, S. S. Cash: Power spectra of local field potentials in different layers of human cortex., Program No. 101.17/VV12. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2008. Online., 2008
D. Fabó, Z. Maglóczky, L. Erőss, A. Sólyom, S. Czirják, G. Rásonyi, P. Halász, T. F. Freund, G. Karmos, I. Ulbert.: Analysis of evoked potentials in the human hippocampal formation elicited by electrical stimulation of the temporo-basal areas., Program No. 644.8/V22. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2008. Online., 2008
Entz L. , Fabó D., Eröss L., Halász P., Wittner L., Karmos G. and Ulbert I.: Cortical electrical stimulation induced slow oscillation in different vigilance states in humans., FENS Forum 2008, Geneva, Switzerland., 2008
Csercsa R., Magony A., Dombovári B., Grand L., Fabó D., Entz L., Wittner L., Eröss L. and Ulbert I.: Laminar properties of sleep slow oscillation in humans., FENS Forum 2008, Geneva, Switzerland., 2008
Wittner L., Vaci P. and Ulbert I.: Patterns of sharp wave-ripple complexes in the rat hippocampus in vitro., FENS Forum 2008, Geneva, Switzerland., 2008
R. Csercsa, A. Magony, D. Fabó, L. Entz, L. Wittner, L. Erõss, I. Ulbert: Special features of sleep slow oscillation in humans., IBRO Workshop 2008. Debrecen, Hungary, P84, 2008
D. Fabó, Zs. Maglóczky, L. Wittner, L. Erõss, P. Halász, T. F. Freund, I. Ulbert: Properties of in vivo interictal spike generation in the human subiculum., IBRO Workshop 2008. Debrecen, Hungary, P103, 2008
L. Entz, D. Fabó, L. Erõss, P. Halász, L. Wittner, Gy. Karmos, I. Ulbert: Effects of electrical stimulation on cortical activity different vigilance states in humans., IBRO Workshop 2008. Debrecen, Hungary, P41, 2008
D. Fabó, Z. Maglóczky, L. Erőss, K. Tóth, L. Entz, S. Czirják, G. Rásonyi, P. Halász, TF. Freund, G. Karmos, I. Ulbert.: Ictal-like beta-gamma band oscillations in the human subiculum under anesthesia., Program#835.10/K11 Neuroscience 2009, SfN's 39th annual meeting, Chicago, USA., 2009
L. Entz, D. Fabó, L. Erőss, P. Halász, L. Wittner, R. Csercsa, B. Dombovári, G. Karmos, I. Ulbert.: Detection of slow oscillation elicited by cortical electrical stimulation in different vigilance states in humans., Program#723.12/F14 Neuroscience 2009, SfN's 39th annual meeting, Chicago, USA., 2009
D. Fabó, Z. Maglóczky, E. Tóth, L. Erőss, A. Sólyom, S. Czirják, G. Rásonyi, P. Halász, TF. Freund, G. Karmos, I. Ulbert.: Evoked potentials and evoked ripples in the human hippocampal formation., A Magyar Idegtudományi Társaság (MITT) XII. Konferenciája, 2009, Budapest., 2009
L. Entz, D. Fabó, L. Erőss, P. Halász, L. Wittner, G. Karmos, I. Ulbert.: Similarities of electrical stimulation induced slow oscillation in different vigilance states in epileptic patients., A Magyar Idegtudományi Társaság (MITT) XII. Konferenciája, 2009, Budapest., 2009




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