Studies on metal binding ability of new siderophore models: Factors affecting the interaction between hydroxamic acids and metal ions  Page description

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Details of project

  
Identifier
49612
Type K
Principal investigator Farkas, Etelka
Title in Hungarian Új sziderofór modellek fémmegkötő sajátságainak vizsgálata: Hidroxámsavak és fémionok közötti kölcsönhatás szelektivitását befolyásoló tényezők
Title in English Studies on metal binding ability of new siderophore models: Factors affecting the interaction between hydroxamic acids and metal ions
Panel Chemistry 1
Department or equivalent Department of Inorganic and Analytical Chemistry (University of Debrecen)
Participants Bátka, Dávid
Enyedy, Éva Anna
Starting date 2005-01-01
Closing date 2009-06-30
Funding (in million HUF) 8.720
FTE (full time equivalent) 4.89
state closed project





 

Final report

  
Results in Hungarian
A kutatás során (1) multikelátor típusú természetes sziderofórok (deszferrioxamin B és deszferrikoprogén) és analógok (pl. EDTA származék hidroxipiridinon), valamint modelljeik fémmegkötő sajátságainak, ezen belül a szelektivitást befolyásoló tényezőknek a vizsgálata, továbbá (2) a fémionokkal relatíve kisebb stabilítású kompexeket képező, “oldalláncukban” imidazolcsoportot tartalmazó új monohidroxámsavak előállítása és fémkomplexeiknek a tanulmányozása folyt. Az (1) témában több rendszernél is feltártuk a fémion-szelektivítást befolyásoló legfontosabb molekulaszerkezeti tényezőket. Bizonyítottuk és értelmeztük, hogy miért lehet pl. ólommérgezés esetén fémionkivonásra hatásosabb a DFC, mint a DFB. Egy lisszaboni laboratóriummal való együttműködésben néhány új hidroxipiridinon, pl. EDTA származék, fémkomplexeinek részletes oldategyensúlyi vizsgálata történt. Eredményeink szerint ezen ligandumok az M3+ és Mo(VI) fémionokat igen nagy hatékonysággal képesek komplexbe vinni, szelektíven kötni . (2) Számos imidazolcsoportot is tartalmazó új monohidroxámsav (mint potenciális metalloenzim inhibítor) előállítása és fémkomplexeik vizsgálata történt. Nemzetközi együttműködésben elindultak azok a vizsgálatok, melyek a monohidroxámsavaink metalloenzimek katalitikus centrumát modellező komplexekkel való kölcsönhatásának felderítésére irányulnak.
Results in English
(1) Metal complexation of multichelator type natural siderophores (desferrioxamine B and desferricoprogen), their analogues (such as hydroxypyridinone derivative of EDTA) and some of their models have been investigated. Within this subject, characterization of the main factors determining the metal ion selectivity of these very effective metal binding agents was in the focus of the work. One of the most interesting results helped us to answer the question: Why can be the desferricoprogen a better lead-sequestering agent than desferrioxamine B? (2) Metal binding ability of potentially metalloenzyme inhibitor monohydroxamic acids has been also investigated. As a continuation of the previous work, the effect of the imidazole situating in various distances compared to the hydroxamic function was studied. Following the examination of the binary systems, the interaction of the imidazole containing monohydroxamic acids with model complexes for catalytic centre of metalloenzymes is planned to study nowadays.
Full text https://www.otka-palyazat.hu/download.php?type=zarobeszamolo&projektid=49612
Decision
Yes





 

List of publications

  
D. Bátka and E. Farkas: Effect of imidazole amino nitrogen atoms of hydroxamic acid derivatives on the lead(II)binding properties,, Abstract Book of International Conference on Bioinorg. Chemistry, 2005
A. M. Santos, S. gama, L. Gano, E. farkas: Bis(3-hydroxy-4-pyridinone)-EDTA derivative as a Potential Therapeutic Al-Chelating Agent. Synthesis, Solution Studies and Biological Assays,, Journal of Inorganic Biochemistry, 2005
D. Bátka and E. Farkas: Pb(II)-binding capability of of aminohydroxamic acids: Primary hydroxamic acid derivatives of alfa-amino acids as possible sequestering agents for Pb(II), Journal of Inorganic Biochemistry, 2006
E. Farkas, D. Bátka and É. A. Enyedy: Some factors affecting metal ion selectivity of natural siderophores, desferrioxamine B and desferricoprogen,, Abstract Book of International Conference on Bioinorg. Chemistry, 2005
D. Bátka and E. Farkas: Pb(II) binding ability of hydroxamic acids, Abstract Book of International Conference, 2005
E. Farkas, D. Bátka, E. Csapó, P. Buglyó, W. Haase and D. Sanna:: Synthesis and Characterization of Cu2+, Ni2+ and Zn2+ Binding Capability of Some Amino- and Imidazole Hydroxamic Acids: Effects of Substitution of Side Chain Amino-N for, Polyhedron, 2007
M. A. Santos* S. Gama, J. Costa Pessoa, M. C.Oliveira, I. Tóth, E. Farkas*:: Complexation of Molybdenum(VI) with Bis(3-Hydroxy-4-Pyridinone)-Aminoacid Derivatives, Eur. J. Inorg. Chem.,, 2006
E. Farkas, D. Bátka, P. Buglyó and M. A. Santos: Hydroxamic Acids as Potential Lead(II) Sequestering Agents: Factors Affecting Lead(II) Binding Properties of Hydroxamic Acids, Metal Ions in Biology and Medicine, 2006, 9, 101-104, 2006
Bátka D., Csóka H. és Farkas E: Az imidazolcsoport szerepe a vas(III)-hidroamát kölcsönhatásban, XLI. Komplexkémiai Kollokvium, 2006, 2006
E. Farkas, D. Bátka and P. Buglyó: Hydroxamic acids as potential sequestering agents of the toxic lead(II) ion: Essential factors affecting lead(II) binding ability of hydroxamic acids, 7th International Symposium on „Metal Elements in Environment, Medicine and Biology, Timisoara (Temesvar), Romania, pp. 49-54, 2006
E. Farkas, E. Csapó, D. Bátka and P. Buglyó: Cu2+, Ni2+ and Zn2+binding capability of potentially metalloenzyme inhibitor new hydroxamic based compounds, 9th ISABC (International Symposium on Applied Bioinorganic Chemistry) Napoli, Italy 2006, 2006
E. Farkas: Some factors affecting the metal ion selectivity of hydroxamate-based compounds, Macro and Trace Elements: Agricultural, Biological, Environmental, Nutritional and Medical Importance of Macro, Trace and Ultra Trace Elements, 26th Worksop 2006, Jena, G, 2006
A. Preokofieva, A. I. Prokhod’ko, E. A. Enyedy, E. Farkas, W. Maringelle, S. Demishko, S. Dechert and F. Meyer:: Oligonuclear Copper Complexes of a Bioinspired Pyrazolate-Bridging Ligand: Synthesis, Structures and Equilibria in Solution, Inorganic Chemistry, 2007
Etelka Farkas*, Dávid Bátka, Hajnalka Csóka and Nóra Nagy: Interaction of imidazole containing hydroxamic acids with Fe(III): Hydroxamate versus imidazole coordination of the ligands, Bioinorganic Chemistry and Application, 2007
P. Buglyó, E. M. Nagy, E. Farkas, I. Sóvágó, D. Sanna, G. Micera: New insights into the metal ion–peptide hydroxamate interactions: Metal complexes of primary hydroxamic acid derivatives of common dipeptides in aqueous solution,, Polyhedron, 2007
Etelka Farkas: Structure-based differences between the metal ion selectivity of two siderophores Desferrioxamine B and Desferricoprogen,, 13th ICBIC (International Conference on BioInorganic Chemistry), invited section lecture, Bécs, Ausztria, 2007, 2007
Etelka Farkas, Dávid Bátka, Edit Csapó and Péter Buglyó: Effects of RN ÉS RC Substituents on the Metal Binding Capability of Potentially Metalloenzyme Inhibitor Hydroxamic Acids, 2nd European Conference on Chemistry for Life Sciences, 2007
Etelka Farkas, Edit Csapó, Péter Buglyó and Giuseppe Pappalardo: The role of imidazole in the metal-binding ability of histidine containing peptidehydroxamic acids, 2nd European Conference on Chemistry for Life Sciences, 2007
E. Farkas, E. Csapó, P. Buglyó, C.A. Damante and G. Di Natale: Metal binding ability of histidine containing peptidehydroxamic acids: Imidazole versus hydroxamate coordination, Inorg. Chim. Acta., 2009
E. Farkas, D. Bátka, G. Kremper and I Pócsi,: Structure-based differences between the metal ion selectivity of two siderophores desferrioxamine B (DFB) and desferricoprogen (DFC): Why DFC is much better Pb(II) sequestering agent than DFB?, J. Inorg. Biochem, 2008
S. Gama, P. Dron, S. Chaves, E. Farkas and M. A Santos.: A bis(3-hydroxy-4-pyridinone)-EDTA derivative as a strong chelator for M3+ hard metal ions: complexation ability and selectivity,, Dalton Trans, 2009
S. Gama, M. Gil, L. Gano, E. Farkas and M. A. Santos,: Combined Complexation of a Bi-functional Bis-hydroxypyridinone with a Deferiprone Derivative for Chelation Therapy. Preparation, Solution Studies and in vivo Evaluation,, J. Inorg. Biochem., 2009
H. Müller, B. Bauer-Siebenlist, E. Csapó, S. Dechert, E. Farkas and F. Meyer,: New pyrazole-based ligands with two tripodal binding pockets: Potential scaffolds for metallobiosite modelling, Inorg. Chem., 2008



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