Neuroanatomical and neurochemical studies on viscero- and somatosensory neuronal pathways  Page description

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Details of project

  
Identifier
49861
Type NI
Principal investigator Palkovits, Miklós
Title in Hungarian Viszcero- és szomatoszenzoros agypályák neuroanatómiai és neurokémiai vizsgálata
Title in English Neuroanatomical and neurochemical studies on viscero- and somatosensory neuronal pathways
Panel Neurosciences
Department or equivalent Neuromorphological and Neuroendocrine Research Laboratory (Office for Research Groups Attached to Universities and Other Institutions)
Participants Boros, Csaba
Gallatz, Katalin
Guttmanné Reichart, Anikó
Kovács, Zsolt István
Kozsurek, Márk
Markia, Balázs
Papp, Rege Sugárka
Réthelyi, Miklós
Szabó-Meltzer, Kinga Ibolya
Uhereczky, Gabriella
Starting date 2005-01-01
Closing date 2008-06-30
Funding (in million HUF) 47.125
FTE (full time equivalent) 12.57
state closed project





 

Final report

  
Results in Hungarian
A program célkitűzése különböző agypályák neuroanatómiai és neurokémiai vizsgálata, valamint 10 fiatal agykutató (PhD, TDK) képzése volt. A kutatási terv célkitűzéseit megvalósítottuk: 3 hallgató készítette el PhD téziseit. Az alábbi eredményeket 18 dolgozatban közöltük (impakt faktor: 101.077) és 19 kongresszusi előadásban/poszteren ismertettük. 1) Elsőként lokalizáltuk a vestibularis stressz pályáját. 2) Új termoszenzitív agypálya leírása. 3) A hibernáció folyamata (6 fázis) alatt bekövetkező funkcionális morfológiai változások „system neuroscience” típusú értékelése (hely, idő, működés rendszerfüggő értékelése). 4) A trigeminális fájdalom okozta stressz pályájának finom topográfiája. 5) A prefrontális agykéregnek a gyomor működést befolyásoló poliszinaptikus (prelimbic-cingulate-amygdala-vagus) pálya topográfiai feldolgozása. 6) Elsőként igazoltuk, hogy a patkány és emberi hippocampus CA2 area idegsejtjei vasopressin 1b receptort szintetizálnak, aminek a szociális viselkedésben és agresszivitásban van szerepe. 7) Kimutattuk a táplálékfelvételben szerepet vivő nucleus arcuatus neuronok direkt kapcsolatát a nyúlt- és gerincvelői preganglionáris idegsejtekkel. 8) Retrograd transz-szinaptikus pályajelöléssel lokalizáltuk a gyomrot és a duodenumot szelektive beidegző spinalis, agytörzsi és hypothalamikus neuronokat. 9) Felderítettük a sacralis gerincvelőben levő és ide érkező idegrostok kémiai karakterét, végződésük térbeli rendjét és e terület speciális ependyma strukturáját.
Results in English
Neuroanatomical and neurochemical studies on viscerosensory and visceromotor pathways constituted the major goals of this project, in addition to the training of 10 PhD fellows and medical students for basic neuroscience. The program of the project has been completed. The results have been published in 18 manuscripts (impact factor: 101.077) and presented in 19 lectures or posters. Three fellows compiled their PhD theses. Major new findings: 1) First description of the pathway of the vestibular stress. 2) Demonstration of the existence of a brainstem-preoptic thermosensitive pathway. 3) Functional anatomical evaluation of the activity of central regulatory mechanisms during the 6 phases of hibernation. 4) Localization of the pain-related trigemino-hypothalamic pathway. 5) Description of the medial prefrontal-amygdala-vagus neuronal circuit that may influence gastric activities. 6) First demonstration of the synthesis of vasopressin 1b receptors in rat and human CA2 hippocampal neurons. 7) Demonstration of hypothalamic arcuate nucleus projections to medullary and spinal preganglionic neurons. 8) Localization of spinal, brainstem and hypothalamic neurons, which participate in the selective innervations of the stomach and the duodenum. 9) The chemical character, the spatial arrangement of nerve fibers in the sacral spinal cord, as well as the special, labyrinth-like structure of the sacral ependyma has been determined.
Full text http://real.mtak.hu/2039/
Decision
Yes





 

List of publications

  
Mravec B; Bodnár I; Uhereczky G; Nagy GM; Kvetnansky R; Palkovits M: Formalin attenuates in stress-induced increase in plasma epinephrine levels., J Neuroendocrinol 17:727-732, 2005
Réthelyi M; Oszwald EH: Chemically labeled neurons in the sacral spinal segments of the cat., Clin Neurosci 58 (S1): 80-81, 2005
Kozsurek M; Puskár Z; Marosfői L; Gerber G; Réthelyi M: Two types of mu opioid receptor-1 expressing cells in the rat spinal substantia gelatinosa., Clin. Neurosci. 58 (S1):56-57, 2005
Kozsurek M; Puskár Z; Marosfői L; Gerber G; Réthelyi M: Mikron-opioid receptor expression of substantia gelatinosa neurons hyperpolyrazide by DAMGO., 5th Int Symp Exp Clin Neurobiol, Stara Lesna, p 55, 2005
Tóth IE; Tóth DE; Boldogkői Zs; Hornyák Á; Palkovits M; Blessing WW: Serotonin synthesizing neurons in the rostral medullary raphé/parapyramidal region transneuronally labelled after injection of pseudorabies virus into the rat tail,, Neurochem Res 31:277-286, 2006
Mitro A; Gallatz K; Daxnerova Z; Novak M; Palkovits M: Ependyma of the central canal in rats, Morfologia v sucasnosti, Polak S, Pospisilova S, Varga V (eds), 2006
Kozicz TL; Derks N; Tilburg-Ouwens D; Palkovits M; Roubos EW: Alteration in urocortin 1 and BDNF-expression in the human Edinger-Westphal nucleus in depression,, 36th Ann Meet Soc Neurosci, Atlanta, 2006
Bencze V; Reichart A; Palkovits M: Infralimbic/cingulate cortical projections to the mygdala, Int IBRO Workshop, Budapest, 2006
Bratincsák A; Kovács Zs; Palkovits M: Direct neuronal projection from a brainstem thermosensitive cell groups to the preoptic thermoregulatory center, Neuroscience (közlésre elfogadva), 2008
Reichart A; Bencze V; Uhereczky G; Boldogkoi Zs; Palkovits M: Multisynaptic connections between the medial prefrontal cortex and the amygdala in rat, Neurosci Lett (közlésre elküldve), 2008
Gaszner B; Korosi A; Palkovits M; Roubos EW; Kozicz T: Neuropeptide Y activates urocortin 1 neurons in the nonpreganglionic Edinger-Westphal nucleus, J Comp Neurol 500:708-719, 2007
Kozicz T; Tilburg-Ouwens D, Faludi G; Palkovits M; Roubos E: Gender-related urocortin 1 and brain-derived neurotrophic factor expression in the adult human midbrain of suicide victims with major depression, Neuroscience 152:1015-1023, 2008
Kovacs ZsI; Palkovits M: Projections from the hypothalamic arcuate neurons to the vagal nuclei, Neurosci Lett (előkészületben), 2008
Boros Cs; Lukacsi E; Horvath-Oszwald E; Rethelyi M: Neurochemical architecture of the filum terminale in the rat, Brain Res 1209:105-114, 2008
Rethelyi M; Horvath-Oszwald E; Boros Cs: Caudal end of the rat spinal dorsal horn, Neurosci Lett (közlésre elfogadva), 2008
Rezek Ö; Boldogkői Zs; Tombácz D; Kővágó Cs; Gerendai I; Palkovits M; Tóth IE: Location of paraotid preganglionic neurons in the inferior salivatory nucleus and their relation to the superior salivatory nucleus of rat, Neurosci Lett 440:265-269, 2008
Kovacs ZsI; Palkovits M: Techniques to further improve the precision of stereotaxic tracer injections, NeuroImage (közlésre elküldve), 2008
Lee HJ; Kannan G; Palkovits M; Young S: Differential gene expression profiling in Avpr1b knockout mouse brain, 37th Ann Meet Soc Neurosci, Washington, 2008
Palkovits M: Hypothalamic arcuate nucleus: neurons in the meeting-point of central autonomic and neuroendocrine regulatory systems, Acta Biol Szegediensis 51 (Suppl 1):36, 2007
Mitro A; Gallatz K; Novak M; Palkovits M: Heterogeneity of the spinal ependyma in rats, Int IBRO Workshop Budapest, 2006
Reichart A; Bencze V; Palkovits M: Participation of limbic neurons in the innervation of the stomach, Clin Neurosci 58 (S1):80, 2005
Papp RS; Kirschenbaum D; Kurucz P; Renner É; Palkovits M: Orexin and MCH cells regulating viscceromotor function of the antrum and the proximal duodenum, Clin Neurosci (közlés alatt), 2008
Palkovits M: The organization of stress-related catecholamine systems, 37th Ann ISPNE Conference, Leiden, Abstract S045, p 51, 2006
Kurucz P; Kirschenbaum D; Micskó T; Trajer A; Gallatz K; Toth IE; Palkovits M: The selective central innervation of the ulcer-sensitive regions of the stomach and the dudoneum in intact and vagotomized rats, Neuroscience (előkészületben), 2008
Kurucz P; Micsko T; Kirschenbaum D; Palkovits M: Hypothalamic, limbic and medullary innervation of the stomach and the duodenum in vagotomized rats, Clin Neurosci 60 (S1):38, 2007
Kurucz P; Micsko T; Trajer A; Toth IE; Gallatz K; Palkovits M: Selective innervation of the ulcer-sensitive regions in the stomach and duodenum, Int IBRO Workshop Budapest, A97, 2006
Fodor M; Rostene W; Berod A; Bencze V; Palkovits M: Projections of VIP/PHI neurons of the interstitial nucleus of Cajal in the rat, Clin Neurosci 60:89-93, 2007
Markia B; Kovács ZsI; Palkovits M: Projections from the vestibular nuclei to the hypothalamic paraventricular nucleus: morphological evidence for the existence of a vestibular stress pathway in the rat brain, Brain Struct Funct 213:239-245, 2008
Bratincsak A; McMullen D; Miyake S; Toth ZE; Hallenbeck JM; Palkovits M: Spatial and temporal activation of brain regions in hibernation: c-fos expression during the hibernation bout in thirteen-lined ground squirrel, J Comp Neurol 505:443-458, 2007
Bratincsak A; Palkovits M: Evidence that peripheral rather than intracranial thermal signals induce thermoregulation, Neuroscience 135:525-532, 2005
Denes A; Boldogkoi Zs; Hornyak A; Palkovits M; Kovacs KJ: Attenuated pseudorabies virus-evoked rapid innate immune response in the rat brain, J Neuroimmunol 180:88-103, 2006
Dobolyi A; Irwin S; Makara G; Usdin T; Palkovits M.: Calcitonin gene-related peptide-containing pathways in the rat forebrain., J Comp Neurol 489:92-119, 2005
Dwivedi Y; Mondal AC; Rizavi HS; Faludi G; Palkovits M; Sarosi A; Conley RR; Pandey GN: Differential and brain region - Specific regulation of Rap-1 and Epac in depressed suicide victims,, Arch Gen Psychiatry 63:639-648, 2006
Landgraf P; Rusu M; Sheridan R; Sewer A; Iovino N; Aravin A; Pfeffer S; Rice A; Kamphorst AO, Landthaler M, Lin C, Socci ND, Hemida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A et al: A mammalian microRNA expression atlas based on small RNA library sequencing, Cell 129:1401-1414, 2007
Lee HJ; Palkovits M; Young WS III: mir-7b, a microRNA up-regulated in the hypothalamus after chronic hyperosmolar stimulation, inhibits Fos translation,, Proc Natl Acad Sci USA 103:15669-15674, 2006
Shahar T; Palkovits M: Cross over of forebrain and brainstem neuronal projections to spinal cord sympathetic preganglionic neurons in the rat, Stress 10:145-154, 2007
Wang J; Palkovits M; Usdin TB; Dobolyi A: Afferent connections of the subparafascicular area in rat, Neuroscience 138:197-220, 2006
Young WS; Li J; Wersinger SR; Palkovits M: The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy, Neuroscience 143:1031-1039, 2006



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