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Expression and function of ABC transporters in human stem cells and during cell differentiation
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List of publications |
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Seres L, Cserepes J, Elkind NB, Törőcsik D, Nagy L, Sarkadi B, Homolya L.: Functional ABCG1 expression induces apoptosis in macrophages and other cell types, Biochim Biophys Acta. 1778, 2378-2387, 2008 | Orbán TI, Seres L, Ozvegy-Laczka C, Elkind NB, Sarkadi B, Homolya L: Combined localization and real-time functional studies using a GFP-tagged ABCG2 multidrug transport, Biochem Biophys Res Commun. 367, 667-673, 2008 | Szakács, G., Váradi, A, Özvegy-Laczka, C, and Sarkadi, B.: The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicology (ADME-Tox), Drug Discovery Today, 2008 | Apáti A, Orbán TI, Varga N, Németh A, Schamberger A, Krizsik V, Erdélyi-Belle B, Homolya L, Várady G, Padányi R, Karászi E, Kemna EW, Német K, Sarkadi B.: High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells., Biochim. Biophys. Acta, 2008 | Hegedűs C, Szakács, G., Homolya, L., Orbán, T.I., Telbisz, Á., Jani, M., and Sarkadi B.: Ins and outs of the ABCG2 multidrug transporter: an update of in vitro functional assays., Advanced Drug Delivery Reviews, 2009 | Hegedűs, C, Özvegy-Laczka, C., Szakács, G., and Sarkadi, B.: Interaction of anticancer protein kinase inhibitors with ABC multidrug transporters: substrates and/or inhibitors?, Current Cancer Drug Targets, 2009 | Orbán TI, Apáti A, Németh A, Varga N, Krizsik V, Schamberger A, Szebényi K, Erdei Z, Várady G, Karászi E, Homolya L, Német K, Gócza E, Miskey C, Mátés L, Ivics Z, Izsvák Z, Sarkadi B.: Applying a double-feature promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery., Stem Cells, 27, 1077-1087, 2009 | Hegedus C, Ozvegy-Laczka C, Apáti A, Magócsi M, Német K, Orfi L, Kéri G, Katona M, Takáts Z, Váradi A, Szakács G, Sarkadi B.: Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties., Brit. J. Pharmacol. 158, 1153-1164, 2009 | Hou, Yue-xian; Li, Chang-Zhong; Palaniyandi, Kanagaraj; Magtibay, Paul; Homolya, Laszlo; Sarkadi, Balazs; Chang, Xiu-bao: Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport, Biochemistry 48, 9122-9131, 2009 | Polgar O, Ediriwickrema LS, Robey RW, Sharma A, Hegde RS, Li Y, Xia D, Ward Y, Dean M, Ozvegy-Laczka C, Sarkadi B, Bates SE.: Arginine 383 is a crucial residue in ABCG2 biogenesis, Biochim Biophys Acta. 1788, 1434-1443., 2009 | Katona M, Kiss K, Angyal V, Kucsma N, Sarkadi B, Takáts Z, Szakács G.: A mass spectrometry based functional assay for the quantitative assessment of ABC transporter activity, Rapid Commun Mass Spectrom. 23, 3372-3376, 2009 | Sarkadi B, Orbán TI, Szakács G, Várady G, Schamberger A, Erdei Z, Szebényi K, Homolya L, Apáti A.: Evaluation of ABCG2 expression in human embryonic stem cells: crossing the same river twice?, Stem Cells, 28, 174-176., 2010 | Nathwani SM, Butler S, Fayne D, McGovern NN, Sarkadi B, Meegan MJ, Lloyd DG, Campiani G, Lawler M, Williams DC, Zisterer DM.: Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells., Cancer Chemother Pharmacol. 66, 585-596, 2010 | Kasza I, Hegyi Z, Szabó K, Andrikovics H, Német K, Váradi A, Sarkadi B, Homolya L.: Model system for the analysis of cell surface expression of human ABCA1, BMC Cell Biol. e-pub 10, 93-104, 2010 | Schneider CK, Salmikangas P, Jilma B, Flamion B, Todorova LR, Paphitou A, Haunerova I, Maimets T, Trouvin JH, Flory E, Tsiftsoglou A, Sarkadi B, Gudmundsson K, O'Donovan M, Migliaccio G, Ancāns J, Mačiulaitis R, Robert JL, Samuel A, Ovelgönne JH, Hystad M, Fal AM, Lima BS, Moraru AS, Turčáni P, Zorec R, Ruiz S, Akerblom L, Narayanan G, Kent A, Bignami F, Dickson JG, Niederwieser D, Figuerola-Santos MA, Reischl IG, Beuneu C, Georgiev R, Vassiliou M, Pychova A, Clausen M, Methuen T, Lucas S, Schüssler-Lenz M, Kokkas V, Buzás Z, Macaleenan N, Galli MC, Linē A, Gulbinovic J, Berchem G, Frączek M, Menezes-Ferreira M, Vilceanu N, Hrubiško M, Marinko P, Timón M, Cheng W, Crosbie GA, Meade N, di Paola ML, Vandendriessche T, Ljungman P, D'Apote L, Oliver-Diaz O, Büttel I, Celis P.: Challenges with advanced therapy medicinal products and how to meet them., Nat Rev Drug Discov. 9:195-201, 2010 | Greene LM, Nathwani SM, Bright SA, Fayne D, Croke A, Gargliardi M, Mc Elligott AM, O'Connor L, Carr M, Keely NO, O'Boyle NM, Carroll P, Sarkadi B, Conneally E, Lloyd DG, Lawler M, Meegan MJ, Zisterer DM.: The vascular targeting agent Combretastatin-A4 and a novel cis-restricted {beta}-lactam analogue CA-432 induce apoptosis in human chronic myeloid leukemia cells and in ex vivo patient samples including those displaying multidrug resistance., J Pharmacol Exp Ther. 335:302-313., 2010 | Sarkadi B, Szakács G.: Understanding transport through pharmacological barriers--are we there yet?, Nat Rev Drug Discov. 9:897-898., 2010 | Homolya L, Orbán TI, Csanády L, Sarkadi B.: Mitoxantrone is expelled by the ABCG2 multidrug transporter directly from the plasma membrane., BBA Biomembranes 1808:154-163., 2011 | Kolacsek, O., Krízsik, V., Schamberger, A., Erdei, Z., Apáti, Á., Várady, G., Mátés, L., Izsvák, Z., Ivics, Z., Sarkadi, B., and Orbán, T.I.: Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers, Mobile DNA, in press, 2011 | Procházková, J., Kubala, L., Kotasová, H., Gudernová, I., Šrámková, Z., Pekarová, M., Sarkadi, B., and Pacherník, J.: ABC transporters affect detection of intracellular oxidants by fluorescent probes, Free Radical Research, in press, 2011 | Brózik, A., Hegedüs, C., Erdei, Z., Hegedüs, T., Özvegy-Laczka, C., Szakács, G., and Sarkadi, B: Tyrosine Kinase Inhibitors as Modulators of ABC Multidrug Transporters: Substrates, Chemosensitizers or Inducers of Acquired Multidrug Resistance?, Expert Opin. Drug Metab. Toxicol. , in press, 2011 |
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