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Unifying principles of protein folding: understanding folding, unfolding and aggregation at atomic-level by experimental and computational methods
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Here you can view and search the projects funded by NKFI since 2004
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List of publications |
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KISS, R BOZÓKY, Z KOVÁCS, D RÓNA, G FRIEDRICH, P DVORTSÁK, P WEISEMANN, R TOMPA, P PERCZEL, A: Calcium-induced tripartite binding of intrinsically disordered calpastatin to its cognate enzyme, calpain, FEBS Letters 2008 582(15): 2149-2154, 2008 | KISS, R KOVÁCS, D TOMPA, P PERCZEL, A: Local structural preferences of calpastatin, the intrinsically unstructured protein inhibitor of calpain, Biochemistry 2008 47(26): 6936-6945, 2008 | CZAJLIK, A BEKE, T BOTTONI, A PERCZEL, A: Structure and stability of short beta-peptide nanotubes: A non-natural representative of collagen?, Journal of Physical Chemistry B 2008 112(26): 7956-7966, 2008 | Jákli, I Perczel: A The inherent flexibility of peptides and protein fragments quantitized by CD in conjunction with CCA+., J. Pept. Sci. 2009, 15(11): 738-752, 2009 | Dobó, J Harmat, V Beinrohr, L Sebestyén, E Závodszky, P Gál: MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity, J. Immunol. 2009, 183:1207-1214., 2009 | Beke-Somfai, T Perczel A: Zipper-like unfolding of β-sheets accessed by pioneer water molecules: Atomic resolution of forced unfold reveals different mechanisms for parallel and antiparallel mot, J. Phys. Chem. Lett. 2010, 1:1341-1345., 2010 | Beke-Somfai, T Lincoln, P Nordén, B: Mechanical control of ATP synthase function: Activation energy difference between tight and loose binding sites., Biochemistry 2010, 49: 401-403., 2010 | Beke, T Somlai, Cs Magyarfalvi, G Perczel, A Tarczay: Chiral and achiral fundamental conformational building units of -peptides: Isolation conformational study on Ac--HGly-NHMe and Ac--HAla-NHMe., J. Phys. Chem. B 2009, 113:7918-7926., 2009 | Kövér, KE Lipták, A Beke, T Perczel, A: Combined NMR three-bond scalar coupling measurements and QM calculations to calculate OH-rotamer equilibrium of polyalcohols., J. Comput. Chem. 2009, 30:540-550., 2009 | Gáspári Z, Várnai P, Szappanos B, Perczel A: Reconciling the lock-and-key and dynamic views of canonical serine protease inhibitor action, FEBS Lett. 584:203-206, 2010 | Szappanos, B Süveges, D Nyitray, L Perczel, A Gáspári, Z: Folded-unfolded cross-predictions and protein evolution: The case study of coiled-coils., FEBS Lett. 2010, 584:1623-1627, 2010 | Láng A, Major B, Szilágyi K, Gáspári Z, Gál P, Závodszky P, Perczel A: Interaction between separated consecutive complement control modules of human C1r: Implications for dimerization of the full-length protease., FEBS Lett. 584, 4565-4569., 2010 | Gáspári Z, Ángyán AF, Dhir S, Franklin D, Perczel A, Pintar A, Pongor S:: Probing dynamic protein ensembles with atomic proximity measures, Curr. Prot. Pept. Sci. 11, 512-522., 2010 | Dhir S, Pacurar M, Franklin D, Gáspári Z, Kertész-Farkas A, Eisenhaber F, Pongor S: Detecting atypical examples of known domain types by sequence similarity searching: The SBASE domain library approach, Curr. Prot. Pept. Sci, 11, 538-549., 2010 | Kovács E, Harmat V, Tóth J, Vértessy BG, Módos K, Kardos J, Liliom K: Structure and mechanism of calmodulin binding to a signaling sphingolipid reveal new aspects of lipid-protein interactions, 1.FASEB J., 24, 3829-3839., 2010 | Ángyán AF, Szappanos B, Perczel A, Gáspári Z: CoNSEnsX: an ensemble view of protein structures and NMR-derived experimental data, BMC Struct. Biol., 10: 39, 2010 | Gáspári Z, Perczel A: Protein dynamics as reported by NMR, Annu. Rep. NMR, 71, pp. 35-75 (szerk.: Graham Webb), Academic Press, 2010 | Láng A, Szilágyi K, Major B, Gál P, Závodszky P, Perczel A: Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r, FEBS J., 277, 3986-3998, 2010 | Zotter Á, Bodor A, Oláh J, Hlavanda E, Orosz F, Perczel A, Ovádi J: Disordered TPPP/p25 binds GTP and displays Mg2+-dependent GTPase activity., FEBS Lett. , 585, 803-808., 2011 | Pohl G, Beke T, Csizmadia IG, Perczel A: Extended apolar beta-peptide foldamers: the role of axis chirality on beta-peptide sheet stability, J. Phys. Chem. B, 114, 9338-9348., 2010 | Pálfi KV, Perczel A: Stability of the Hydration Layer of Tropocollagen: A QM Study, J. Comput. Chem., 31, 764-777., 2010 | Harmat V, Domokos K, Menyhárd DK, Palló A, Szeltner Z, Szamosi I, Beke-Somfai T, Náray-Szabó G, Polgár L: Structure and catalysis of acylaminoacyl peptidase: closed and open subunits of dimer oligopeptidase, J. Biol. Chem. 286, 1987-1998, 2011 | Takács E, Nagy G, Leveles I, Harmat V, Lopata A, Tóth J, Vértessy BG: Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases, FEBS Lett., 584, 3047-3054, 2010 | Pécsi I, Leveles I, Harmat V, Vértessy BG, Tóth J: Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase, Nucl. Acids Res., 38, 7179-7186., 2010 | Zotter, Á Oláh, J Hlavanda, E Bodor, A Perczel, A Szigeti, K Fidy, J Ovádi, J: Zn(2+)-Induced Rearrangement of the Disordered TPPP/p25 Affects Its Microtubule Assembly and GTPase Activity, Biochemistry 2011, 50, 9568-9578, 2011 | Ágoston, BS Kovács, D Tompa, P Perczel, A: Full backbone assignment and dynamics of the intrinsically disordered dehydrin ERD14, BIOMOLECULAR NMR ASSIGNMENTS, 2011, 5, 189-193, 2011 | Zsoldos-Mády, V Pintér, I Perédy-Kajtár, M Perczel, A: Transformation of aldose formazans. Novel synthesis of 2-acetamido-2-deoxypentonolactones and a new pent-2-enose formazan, Carbohydrate Research, 2011, 3461, 1534-1540, 2011 | Rovó, P Farkas, V Hegyi, O Szolomajer-Csikós, O Tóth, GK Perczel, A: Cooperativity network of Trp-cage miniproteins: probing salt-bridges, Journal of Peptide Science, 2011, 9, 610-619, 2011 | Pohl G, Jákli I, Csizmadia IG, Papp D, Matías GF, Perczel A: The role of entropy in initializing the aggregation of peptides: A first principle study on oligopeptide oligomerization, PHYSICAL CHEMISTRY CHEMICAL PHYSICS 14:(4) pp. 1507-1516., 2012 | Pohl G, Beke-Somfai T, Csizmadia IG, Perczel A: Exploiting diverse stereochemistry of b-amino acids: Toward a rational design of sheet-forming b-peptide systems, AMINO ACIDS 43:(2) pp. 735-749., 2012 | Jákli I, Knak Jensen SJ, Csizmadia IG, Perczel A: Variation of conformational properties at a glance. True graphical visualization of the Ramachandran surface topology as a periodic potential energy surface, CHEMICAL PHYSICS LETTERS 547:pp. 82-88., 2012 | Gorrea E, Pohl G, Nolis P, Celis S, Burusco KK, Branchadell V, Perczel A, Ortuño RM: Secondary structure of short β-peptides as the chiral expression of monomeric building units: A rational and predictive model, JOURNAL OF ORGANIC CHEMISTRY 77:(21) pp. 9795-9806., 2012 | Gáspári Z, Süveges D, Perczel A, Nyitray L, Tóth G: Charged single alpha-helices in proteomes revealed by a consensus prediction approach, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1824:pp. 637-646., 2012 |
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