Novel non-enveloped viruses with positive, single-stranded RNA (+ssRNA) genome and its host species  Page description

Help  Print 
Back »
 

Details of project

  
Identifier
83013
Type K
Principal investigator Reuter, Gábor
Title in Hungarian Új, burok néküli, pozitív, egyszálú RNS (+ssRNS) genomú vírusok és gazdafajaik
Title in English Novel non-enveloped viruses with positive, single-stranded RNA (+ssRNA) genome and its host species
Keywords in Hungarian új,+ssRNS, virus, genom, genetikai variábilitás, szekvencia sokszínűség, molekuláris epidemiológia, metagenomika, gazdaszervezet, ember, állat
Keywords in English novel, +ssRNA, virus, genome, genetic variability, sequence diversity, molecular epidemiology, metagenomics, host species, human, animal
Discipline
Microbiology: virology, bacteriology, parasitology, mycology (Council of Medical and Biological Sciences)50 %
Epidemiology, veterinary microbiology (Council of Complex Environmental Sciences)30 %
Microbiology: virology, bacteriology, parasitology, mycology (Council of Medical and Biological Sciences)20 %
Panel Immunity, Cancer and Microbiology
Department or equivalent Government Office for Baranya County, Institute of State Public Health Service
Participants Boros, Ákos
Pankovics, Péter
Starting date 2011-02-01
Closing date 2015-01-31
Funding (in million HUF) 13.900
FTE (full time equivalent) 6.40
state closed project
Summary in Hungarian
A burok nélküli, pozitív egyszálú RNS (+ssRNS) genomú vírusok - melyek evolúciós szinten prokarióta mRNS molekulákat utánoznak – a legszámosabbak a planétán; 27 víruscsaládja ismert, melyek közül 9 víruscsalád emlősök vírusai, és a számuk gyorsan emelkedik a korszerű metagenomikai módszerek segítségével. A burok nélküli vírusok az Astroviridae, Caliciviridae, Hepeviridae és a Picornaviridae családokban számos közös és jellegzetes tulajdonsággal rendelkeznek.
A kutatással megvalósítható, hogy (1) ígéretes mintákból, szisztematikusan, RT-PCR módszerekkel keressük és mutassuk ki a burok nélküli +ssRNS genomú vírusok új fajait és nemzetségeit (vírus diverzitás) a vírusok nagyon konzervatív genetikai motívumaira elméletileg lehetséges nukleotid variációkat figyelembe vevően tervezett konzervatív (és degenerált) primerek kombinációival; (2) „genome-walking” és korszerű metagenomikai módszerekkel (pl.: 454-pyroszekvenálás) meghatározhassuk az ígéretesen új vírus(ok) teljes genetikai állományát(-ait); és (3) molekuláris módszerekkel kimutassuk és jellemezzük az újonnan azonosított vírus variáns(ok), faj(ok) vagy nemzetség(ek) tagjait (beleértve a újonnan azonosított potenciálisan új picornavírus nemzetséget a „Hungarovirus”-t) a lehető legtöbb gazdafajból (gazdafaj diverzitás) így emberből is. A kutatással kitölthetjük és folytathatjuk azt a virtuális táblázatot, ahol a sorok a burok nélküli +ssRNS vírusok nemzetségeit és fajait, az oszlopok ezek gazdafajait tartalmazzák.
Summary
Viruses with positive, single-stranded RNA (+ssRNA) genome – which evolutionally imitate prokaryote mRNA molecule - are the most plentiful on this planet; 27 families have been recognized, including 9 families which infect mammals, and this number is increasing rapidly using up-to-date metagenomic methods. Non-enveloped +ssRNA viruses in families Astroviridae, Caliciviridae, Hepeviridae and Picornaviridae have many common and characteristic features.
In this research project there will be a (1) systematic search for identification of novel (species or genus of) non-enveloped viruses with +ssRNA genome (virus diversity) using a combination of conserved (and degenerate) primers designed for highly conserved genetic motifs based upon the theoretically possibly nucleotide variations from promising samples by RT-PCR methods; (2) characterization of the complete genome of novel promising virus(es) by genome-walking and up-to-date viral metagenomics methods (like 454-pyrosequencing); and (3) detection and characterization of the identified novel virus variant(s), species or genus (including the recently identified potential new picornavirus genus “Hungarovirus”) by molecular methods in as many animal host species as possible (host species diversity) including human. With this research, we can fill up and continue the virtual table where the rows represent the genera or species of non-enveloped +ssRNA viruses and the columns represent the range of its host species.




 

Final report

  
Results in Hungarian
Az (re)emerging fertőző betegségek folyamatos fenyegetést jelentenek a házi és vadon élő állatokra és az emberre. A kutatásaink alátámasztják feltételezésünket, hogy új, burok nélküli, pozitív, egyszálú RNS (+ssRNS) genomú vírusokat lehet azonosítani a már ismert rokon vírusok genom-jellegzetességei figyelembe vételével a gazdafajok szisztematikus vizsgálatával. A négy kutatási év alatt több új vírusgeno-/szerotípus mellett összesen 19 taxonómiailag is új vírusfajt és ebből egyben 13 potenciálisan új névadó vírusnemzetséget (név szerint a Picornaviridae családban: Avisivirus, Gallivirus, Hunnivirus, Megrivirus, ”Kunsagivirus”, ”Sakobuvirus”, ”Falcovirus”, ”Orivirus”, ”Rafivirus”, ”Mesivirus”, ”Phacovirus”; a Picornavirales rendben: ”Halastavi árva RNA virus”, ”Fisavirus”) sikerült felfedezni és teljes genomjukat meghatározni 14 gazdafajból (emlősökből, madarakból, hüllőből és halból). A munka eredményei hozzájárultak a +ssRNS genomú vírusok diverzitásának megismeréséhez, a vírustaxonómia fejlődéséhez, a vírusok közötti mélyebb (valósabb) genetikai és evolúciós összefüggések, gazdafaj-specificitás és váltás (gazdafaj diverzitás), a rezervoir szerep, valamint a faji-határátlépések összefüggéseinek megértéséhez és erősítette az ember-állat-környezet egységében, a „One Health” koncepcióban való gondolkodást, együttműködést. Az eredményeket 36 elfogadott, illetve benyújtott „peer-reviewed” közleményben (+2 angol és 1 magyar nyelvű felkért könyvfejezetben) publikáltuk (ΣIF: 97,475)
Results in English
The (re)emerging infectious diseases pose a continuous threat to domestic and wild animals and humans. This study confirms our hypothesis that it is possible to discover novel, non-enveloped viruses with positive-sense, single-stranded RNA (+ssRNA) genome if we take account of the viral genome characteristics of known relatives and by systematic investigation of host species. During the 4-research-years, beside several novel viral geno-/serotypes, we were discovered and completely characterized a total of 19 taxonomically novel virus species including 13 potential novel, name founder viral genera (namely in family Picornaviridae: Avisivirus, Gallivirus, Hunnivirus, Megrivirus, ”Kunsagivirus”, ”Sakobuvirus”, ”Falcovirus”, ”Orivirus”, ”Rafivirus”, ”Mesivirus”, ”Phacovirus”; in order Picornavirales: ”Halastavi árva RNA virus”, ”Fisavirus”) from 14 host species (in mammals, birds, reptile and fish). The results of this study contributes to better recognition the diversity, progress of virus taxonomy and to understand deeper (real) genetic and evolutional relationship, host-species specificity and switch (host species diversity), reservoir role and cross-species transmission of +ssRNA viruses as well as it improved the integrative thinking and collaboration related to human-animal-environment in “One Health” conception. Results were accepted or submitted for publication in 36 peer-reviewed articles (+2 English and 1 Hungarian invited book chapters) (ΣIF: 97.475).
Full text https://www.otka-palyazat.hu/download.php?type=zarobeszamolo&projektid=83013
Decision
Yes





 

List of publications

  
Ng TFF, Wellehan JFX, Kondov NO, Deng X, Waltzek TB, Reuter G, Knowles NJ, Delwart E: First reptile-infecting picornavirus expands the host range of Picornaviridae, Arch Virol, in press, 2015
Boros Á, Pankovics P, Simmonds P, Pollák E, Mátics R, Phan TG, Delwart E, Reuter G: Genome analysis of a novel, highly divergent picornavirus from common kestrel (Falco tinnunculus): The first non-enteroviral picornavirus with type-I-like IRES, Infection, Genetics and Evolution, in press, 2015
Pankovics P, Boros Á, Kiss T, Delwart E, Reuter G: Novel mamastrovirus in bird, European roller (Coracias garrulus), Infection, Genetics and Evolution, submitted, 2015
Boros Á, Fenyvesi H, Pankovics P, Bíró H, Phan GT, Delwart E, Reuter G: Secondary structure analysis of swine pasivirus (family Picornaviridae) RNA reveals type-IV IRES and parechovirus-like 3’UTR organization., ARCH VIROL in press, 2015
Pankovics P, Boros Á, Nemes C, Delwart E, Reuter G: Nebovírus (Caliciviridae) első hazai kimutatása hasmenéses borjú bélsármintájából, MAGYAR ÁLLATORVOSOK LAPJA 135: (1) 12-17, 2013
Phan TG, Vo NP, Boros Á, Pankovics P, Reuter G, Wang C, Deng X, Poon LLM, Delwart E: The viruses of wild pigeon droppings, PLOS ONE 8: (9) , 2013
Reuter G, Boros Á, Delwart E, Pankovics P: Novel seadornavirus (family Reoviridae) related to Banna virus in Europe, ARCH VIROL 158: (10) 2163-2167, 2013
Reuter G, Pankovics P, Delwart E, Boros Á: Novel posavirus-related single-stranded RNA virus from fish (Cyprinus carpio), ARCH VIROL in press, 2015
Reuter G, Nemes C, Boros Á, Kapusinszky B, Delwart E, Pankovics P: Porcine kobuvirus in wild boars (Sus scrofa), ARCH VIROL 158: 281-282, 2013
Boros Á, Nemes C, Pankovics P, Bíró H, Kapusinszky B, Delwart E, Reuter G: Characterization of a novel porcine enterovirus in wild boars in Hungary, ARCH VIROL 157: 981-986, 2012
Boros Á, Nemes C, Pankovics P, Kapusinszky B, Delwart E, Reuter G: Porcine teschovirus in wild boars in Hungary, ARCH VIROL 157: (8) 1573-1578, 2012
Boros Á, Nemes C, Pankovics P, Kapusinszky B, Delwart E, Reuter G: Identification and complete genome characterization of a novel picornavirus in turkey (Meleagris gallopavo), J GEN VIROL 93: 2171-2182, 2012
Boros Á, Pankovics P, Knowles NJ, Reuter G: Natural interspecies recombinant bovine/porcine enterovirus in sheep, J GEN VIROL 93: 1941-1951, 2012
Knowles NJ, Reuter G: Porcine caliciviruses, In: Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW (szerk.) (szerk.) Diseases of Swine (10th edition). Ames: Wiley-Blackwell Publishing Ltd., 2012. pp. 493-500., 2012
Pankovics P, Boros Á, Reuter G: Novel picornavirus in domesticated common quail (Coturnix coturnix) in Hungary., ARCH VIROL 157: (3) 525-530, 2012
Pankovics P, Boros Á, Szabó H, Székely Gy, Gyurkovits K, Reuter G: Human enterovirus 109 (EV109) in acute paediatric respiratory disease in Hungary, ACTA MICROBIOL IMMUNOL HUNG 59: (2) 285-290, 2012
Reuter G, Knowles NJ: Porcine astroviruses, In: Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW (szerk.) (szerk.) Diseases of Swine (10th edition). Ames: Wiley-Blackwell Publishing Ltd., 2012. pp. 487-489., 2012
Reuter G, Nemes C, Boros Á, Kapusinszky B, Delwart E, Pankovics P: Astrovirus in wild boars (Sus scrofa) in Hungary, ARCH VIROL 157: (6) 1143-1147, 2012
Reuter G, Pankovics P, Delwart E, Boros Á: Identification of a novel astrovirus in domestic sheep in Hungary, ARCH VIROL 157: (157) 323-327, 2012
Reuter G, Pankovics P, Knowles NJ, Boros Á: Two closely related novel picornaviruses in cattle and sheep in Hungary from 2008 to 2009, proposed as members of a new genus in the family Picornaviridae, J VIROL 86: (24) 13295-13302, 2012
Reuter G; Pankovics P; Boros Á: Identification of a novel astrovirus in a domestic pig in Hungary, Archives of Virology 156: 125-128, 2011
Pankovics P; Boros Á; Rovács M; Nagy E; Krisztián E; Vollain M; Reuter G: Humán astrovírus okozta gastroenteritis járvány első hazai igazolása, Orvosi Hetilap 152: 45-50, 2011
Reuter G; Boros Á; Pankovics P: Kobuviruses – a comprehensive review, Reviews in Medical Virology 21: 32-41, 2011
Boros Á; Pankovics P; Reuter G: Characterization of a novel porcine enterovirus in domestic pig in Hungary, Infection, Genetics and Evolution 11: 1096-1102, 2011
Reuter G; Új M; Pankovics P; Kolozsi T; Mihály I; Liptai Z; Boros Á: A humán parechovírusok klinikai jelentősége és első hazai azonosítása, Orvosi Hetilap 152: 1007-1012, 2011
Boros Á; Pankovics P; Simmonds P; Reuter G: Novel positive-sense, single-stranded RNA (+ssRNA) virus with di-cistronic genome from intestinal content of freshwater carp (Cyprinus carpio), PLoS One 6: e29145, 2011
Reuter G; Pankovics P; Delwart E; Boros Á: Identification of a novel species of astrovirus in domestic sheep in Hungary, Archives of Virology 157: 323-327, 2012
Pankovics P; Boros Á; Reuter G: Novel picornavirus in domesticated common quail (Coturnix coturnix) in Hungary, Archives of Virology 157: 525-530, 2012
Boros Á; Nemes Cs; Pankovics P; Bíró H; Kapusinszky B; Delwart E; Reuter G: Characterization of a novel porcine enterovirus in wild boars in Hungary, Archives of Virology 157: 981-986, 2012
Reuter G; Nemes Cs; Boros Á; Kapusinszky B; Delwart E; Pankovics P: Astrovirus in wild boars (Sus scrofa) in Hungary, Archives of Virology 157: 1143-1147, 2012
Reuter G; Knowles NJ: Porcine astroviruses, Diseases of Swine 10th ed. Chapter 32 487-489, 2012
Knowles NJ; Reuter G: Porcine caliciviruses, Diseases of Swine 10th ed. Chapter 34 493-500, 2012
Tuzankina I; Kobeleva Y; Kiseleva N; Bolkov M; Reuter G; Maródi L: Cytotoxic T lymphocytes mediate neuronal injury in patients with X-linked agammaglobulinemia and progressive neurodegenerative disease, Allergy 66: 1617-1618, 2011
Boros Á; Pankovics P; Knowles N; Reuter G: Natural interspecies recombinant bovine/porcine enterovirus in sheep, Journal of General Virology 93: 1941-1951, 2012
Boros Á; Nemes C; Pankovics P; Kapusinszky B; Delwart E; Reuter G: Porcine teschovirus in wild boars in Hungary, Archives of Virology 157: 1573-1578, 2012
Pankovics P; Boros Á; Szabó H; Székely Gy; Gyurkovits K; Reuter G: Human enterovirus 109 (EV109) in acute paediatric respiratory disease in Hungary, Acta Microbiologica et Immunologica Hungarica 59(2): 285-290, 2012
Boros Á; Nemes C; Pankovics P; Kapusinszky B; Delwart E; Reuter G: Identification and complete genome characterization of a novel picornavirus in turkey (Meleagris gallopavo), Journal of General Virology 93: 2171-2182, 2012
Reuter G; Pankovics P; Knowles NJ; Boros Á: Two closely related novel picornaviruses in cattle and sheep in Hungary from 2008 to 2009, proposed as members of a new genus in the family Picornaviridae, Journal of Virology 86(24): 13295-13302, 2012
Reuter G; Nemes C; Boros Á; Kapusinszky B; Delwart E; Pankovics P: Porcine kobuvirus in wild boars (Sus scrofa), Archives of Virology 158: 281-282, 2013
Pankovics P; Boros Á; Nemes C; Delwart E; Reuter G: Nebovírus (Caliciviridae) első hazai kimutatása hasmenéses borjú bélsármintájából, Magyar Állatorvosok Lapja 135: 12-17, 2013
Knowles NJ; Boros Á; Pankovics P; Wadsworth J; Reuter G: Typing of bovine, ovine and porcine enteroviruses based on VP1 sequence data: designation of new types, EUROPIC St Raphael, France, 2012. június 3-7., 2012
Knowles NJ; Delwart E; Gorbalenya AE; Hovi T; Hyypia T; King AMQ; Lindberg AM; Pallansch MA; Palmenberg AC; Reuter G; Simmonds P; Skern T; Stanway G; Yamashita T; Zell R: Picornaviridae: the 9th ICTV report and beyond, EUROPIC St Raphael, France, 2012. június 3-7., 2012
Reuter G; Pankovics P; Delwart E; Boros Á: Identification of a novel species of astrovirus in domestic sheep in Hungary, Archives of Virology 157: 323-327, 2012
Pankovics P; Boros Á; Reuter G: Novel picornavirus in domesticated common quail (Coturnix coturnix) in Hungary, Archives of Virology 157: 525-530, 2012
Boros Á; Nemes Cs; Pankovics P; Bíró H; Kapusinszky B; Delwart E; Reuter G: Characterization of a novel porcine enterovirus in wild boars in Hungary, Archives of Virology 157: 981-986, 2012
Reuter G; Nemes Cs; Boros Á; Kapusinszky B; Delwart E; Pankovics P: Astrovirus in wild boars (Sus scrofa) in Hungary, Archives of Virology 157: 1143-1147, 2012
Boros Á; Pankovics P; Knowles N; Reuter G: Natural interspecies recombinant bovine/porcine enterovirus in sheep, Journal of General Virology 93: 1941-1951, 2012
Boros Á; Nemes C; Pankovics P; Kapusinszky B; Delwart E; Reuter G: Porcine teschovirus in wild boars in Hungary, Archives of Virology 157: 1573-1578, 2012
Pankovics P; Boros Á; Szabó H; Székely Gy; Gyurkovits K; Reuter G: Human enterovirus 109 (EV109) in acute paediatric respiratory disease in Hungary, Acta Microbiologica et Immunologica Hungarica 59(2): 285-290, 2012
Boros Á; Nemes C; Pankovics P; Kapusinszky B; Delwart E; Reuter G: Identification and complete genome characterization of a novel picornavirus in turkey (Meleagris gallopavo), Journal of General Virology 93: 2171-2182, 2012
Reuter G; Pankovics P; Knowles NJ; Boros Á: Two closely related novel picornaviruses in cattle and sheep in Hungary from 2008 to 2009, proposed as members of a new genus in the family Picornaviridae, Journal of Virology 86(24): 13295-13302, 2012
Reuter G; Nemes C; Boros Á; Kapusinszky B; Delwart E; Pankovics P: Porcine kobuvirus in wild boars (Sus scrofa), Archives of Virology 158: 281-282, 2013
Pankovics P; Boros Á; Nemes C; Delwart E; Reuter G: Nebovírus (Caliciviridae) első hazai kimutatása hasmenéses borjú bélsármintájából, Magyar Állatorvosok Lapja 135: 12-17, 2013
Boros Á, Nemes C, Pankovics P, Kapusinszky B, Delwart E, Reuter G: Genetic characterization of a novel picornavirus in turkeys (Meleagris gallopavo) distinct from turkey gallivirus and megrivirus and distantly related to the members of t, Journal of General Virology 94: 1496-1509, 2013
Reuter G, Boros Á, Delwart E, Pankovics P: Novel seadornavirus (family Reoviridae) related to Banna virus in Europe, Archives of Virology 158: 2163-2167, 2013
Boros Á, Kiss T, Kiss O, Pankovics P, Kapusinszky B, Delwart E, Reuter G: Genetic characterization of a novel picornavirus distantly related to the marine mammal-infecting aquamaviruses in a long-distance migrant bird species, European Roller, Journal of General Virology 94:2029-2035, 2013
Phan TG, Vo NP, Boros Á, Pankovics P, Reuter G, Wang C, Deng X, Poon LLM, Delwart E: The viruses of wild pigeon droppings, PLoS One 8(9):e72787, 2013
Reuter G, Boros Á, Delwart E, Pankovics P: Novel circular single-stranded DNA virus from turkey faeces, Archives of Virology in press, 2014
Reuter G, Maza N, Pankovics P, Boros Á: Non-primate hepacivirus infection with apparent hepatitis in domestic horse, Acta Veterinaria Hungarica in press, 2014
Boros Á, Pankovics P, Knowles NJ, Nemes C, Delwart E, Reuter G: Comparative complete genome analysis of chicken and turkey megriviruses (family Picornaviridae) reveals unique genome features and unusual sequence relationships in the s, Journal of Virology in press, 2014
Boros Á, Pankovics P, Reuter G: Avian picornaviruses: detection, characterization and comparative genome analysis, EUROPIC 18th Blankenberge, Belgium, 2014. március 9-14., 2014
Knowles NJ, Delwart E, Gorbalenya AE, Hovi T, Hyypiä T, King AMQ, Lindberg AM, Pallansch MA, Palmenberg AC, Reuter G, Simmonds P, Skern T, Stanway G, Yamashita T, Zell R: Picornaviridae: 26 genera, 46 species and growing, EUROPIC 18th, Blankenberge, Belgium, 2014. március 9-14., 2014
Bachanek-Bankowska K, Boros Á, Wadsworth J, Pankovics P, Reuter G, Knowles NJ: Enteroviruses isolated from sheep belong to the recently renamed Enterovirus E (Bovine enterovirus group A) and Enterovirus G (Porcine enterovirus) species, EUROPIC 18th, Blankenberge, Belgium, 2014. március 9-14., 2014
Boros Á, Bachanek-Bankowska K, Wadsworth J, Pankovics P, Reuter G, Knowles NJ: Genome sequence of a third genotype of hunnivirus (previously named hungarovirus) isolated from sheep in Northern Ireland, EUROPIC 18th, Blankenberge, Belgium, 2014. március 9-14., 2014
Pankovics P, Boros Á, Kiss T, Reuter G: Identification and complete genome analysis of kobuvirus in faecal samples of European roller (Coracias garrulus): for the first time in a bird, ARCH VIROL 160: (1) 345-351, 2015
Reuter G: Nukleinsav alapú, molekuláris biológiai vizsgáló módszerek, In: Maródi L (szerk.) Fertőző betegségek. Budapest: Medicina Könyvkiadó Zrt., in press, 2015
Boros Á, Pankovics P, Adonyi Á, Phan TG, Delwart E, Reuter G: Genome characterization of a novel chicken picornavirus distantly related to the members of the genus Avihepatovirus with a single 2A protein and a megrivirus-like 3’UTR, INFECT GENET EVOL 28: 333-338, 2014
Boros Á, Pankovics P, Knowles NJ, Nemes C, Delwart E, Reuter G: Comparative complete genome analysis of chicken and turkey megriviruses (family Picornaviridae): long 3' untranslated regions with a potential second open reading frame and evidence for possible recombination, J VIROL 88: (11) 6434-6443, 2014
Boros Á, Pankovics P, Reuter G: Avian picornaviruses: Molecular evolution, genome diversity and unusual genome features of a rapidly expanding group of viruses in birds, INFECT GENET EVOL 28: 151-166, 2014
Ng TFF, Mesquita JR, Nascimento MSJ, Kondov NO, Wong W, Reuter G, Knowles NJ, Vega E, Esona MD, Deng X, Vinjé J, Delwart E: Feline fecal virome reveals novel and prevalent enteric viruses, VET MICROBIOL 171: (1-2) 102-111, 2014
Reuter G, Boros Á, Delwart E, Pankovics P: Novel circular single-stranded DNA virus from turkey faeces, ARCH VIROL 159: (8) 2161-2164, 2014
Reuter G, Boros Á, Kiss T, Delwart E, Pankovics P: Complete genome characterization of mosavirus (family Picornaviridae) identified in dropping of European roller (Coracias garrulus) in Hungary, ARCH VIROL 159: 2723-2729, 2014
Reuter G, Maza N, Pankovics P, Boros Á: Non-primate hepacivirus infection with apparent hepatitis in horse, ACTA VET HUNG 62: (3) 422-427, 2014
Reuter G, Pankovics P, Gyöngyi Z, Delwart E, Boros Á: Novel dicistrovirus from bat guano, ARCH VIROL 159: (12) 3453-3456, 2014
Boros Á, Kiss T, Kiss O, Pankovics P, Kapusinszky B, Delwart E, Reuter G: Genetic characterization of a novel picornavirus distantly related to the marine mammal-infecting aquamaviruses in a long-distance migrant bird species, European Roller (Coracias garrulus), J GEN VIROL 94: (9) 2029-2035, 2013
Boros Á, Nemes C, Pankovics P, Kapusinszky B, Delwart E, Reuter G: Genetic characterization of a novel picornavirus in turkeys (Meleagris gallopavo) distinct from turkey gallivirus and megrivirus and distantly related to the members of the genus Avihepatovirus, J GEN VIROL 94: (7) 1496-1509, 2013



Back »