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A rendezetlen TPPP/p25 fiziológiás és patológiás kölcsönhatásai: kötő motívumok feltérképezése
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Ezen az oldalon az NKFI Elektronikus Pályázatkezelő Rendszerében nyilvánosságra hozott projektjeit tekintheti meg.
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Oláh J, Szénási T, Szunyogh S, Szabó A, Lehotzky A, Ovádi J: Further evidence for microtubule-independent dimerization of TPPP/p25, Scientific Reports in press, 2017 | Szénási T, Oláh J, Szabó A, Szunyogh S, Láng A, Perczel A, Lehotzky A, Uversky VN, Ovádi J: Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins., BBA-Mol. Basis Disease 1863: 310-323, 2017 | Zwick V , Nurisso A, Simões-Pires C, Bouchet S, Martinet N, Lehotzky A, Ovadi J, Cuendet M, Blanquart C, Bertrand P: Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates., BIOORG MED CHEM LETT 26: (1) 154-159, 2016 | Attila Lehotzky, Judit Oláh, Sándor Szunyogh, Adél Szabó, Tímea Berki, Judit Ovádi: Zinc-induced structural changes of the disordered TPPP/p25 inhibits its degradation by the proteasome, BBA-MOL BASIS DIS 1852: (1) 83-91, 2015 | Judit Oláh , Vic Norris , Judit Ovádi: Modeling of sensing potency of cytoskeletal systems decorated with metabolic enzymes, J THEOR BIOL 365: 190-196, 2015 | M Schiedel; T Rumpf; B Karaman; A Lehotzky; S Gerhardt; J Ovádi; W Sippl; O Einsle; M Jung: Structure-based Development of a Sirtuin 2 Affinity Probe, ANGEW CHEM INT ED 55: (6) 2252-2256, 2015 | Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Olah J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovadi J, Schutkowski M, Sippl W, Einsle O, Jung M: Selective Sirt2 inhibition by ligand-induced rearrangement of the active site., NAT COMMUN 6: 6263, 2015 | Sándor Szunyogh, Judit Oláh, Tibor Szénási, Adél Szabó, Judit Ovádi: Targeting the interface of the pathological complex of α-synuclein and TPPP/p25, BBA-MOL BASIS DIS 1852: 2653-2661, 2015 | Victor Mangas-Sanjuan, Judit Oláh, Isabel Gonzalez-Alvarez, AttilaLehotzky, NatáliaTőkési, Marival Bermejo, Judit Ovádi: Tubulin Acetylation Promoting Potency and Absorption Efficacy of Deacetylase Inhibitors., BR J PHARMACOL 172: (3) 829-840, 2015 | Tőkési Natália, Oláh Judit, Hlavanda Emma, Szunyogh Sándor, Szabó Adél, Babos Fruzsina, Magyar Anna, Lehotzky Attila, Vass Elemér, Ovádi Judit: Identification of motives mediating alternative functions of the neomorphic moonlighting TPPP/p25, BBA-MOL BASIS DIS 1842: (4) 547-557, 2014 | Oláh J, OvádiJ: Dual life of TPPP/p25 evolved in physiological and pathological conditions, BIOCHEM SOC T 42: (6) 1762-1767, 2014 | Ovádi Judit, Vic Norris: Moonlighting Function of the Tubulin Cytoskeleton, In: M A Aon, V Saks, U Schlatter (szerk.) (szerk.) Systems Biology of Metabolic and Signaling Networks: Energy, Mass and Information Transfer. Heidelberg; London; New York: Springer, 2014. pp. 165-179., 2014 | Norris V, Amar P, Legent G, Ripoll C, Thellier M, Ovádi J: Sensor potency of the moonlighting enzyme-decorated cytoskeleton, BMC BIOCHEM 14: (1) , 2013 | Oláh J, Tőkési N, Lehotzky A, Orosz F, Ovádi J: Moonlighting microtubule associated proteins: Physiological functions by day and pathological functions at night., CYTOSKELETON 70: 677-685, 2013 | Oláh J, Zotter Á, Hlavanda E, Szunyogh S, Orosz F, Szigeti K, Fidy J, Ovádi J: MICROTUBULE ASSEMBLY-DERIVED BY DIMERIZATION OF TPPP/p25. Evaluation of thermodynamic parameters for multiple equilibrium system from ITC data, BBA-GEN SUBJECTS 1820: 785-794, 2012 | J. Oláh, N. Tőkési, Á. Zotter, J. Ovádi: Ultrastructure-derived physiological and pathological functions of the disordered TPPP/p25, 9th European Biophysics Congress, Lisbon, Portugal, 13-17, July, 2013 | Tripon R, Csincsik L, Oláh J, Ovádi J, Lengyel I: Immunolocalisation of tubulin polymerisation promoter protein/p25 in the diabetic retina, Eur J F Ophthal 25: E14., 2015 | Bouchet S, Blanquart C, Cuendet M, Ovádi J, Martinet N, Roche J, Fouchaq B, Bertrand P.: Synthesis of HDAC inhibitors using cross metathesis and their biological evaluations, Belgrade BioInformatics Conference Serbia, 2016 | Szénási T, Oláh J, Szabó A, Szunyogh S, Láng A, Perczel A, Lehotzky A, Uversky VN, Ovádi J: Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins, BBA-Mol. Basis Disease 1863: 310-323, 2017 | Ovádi J: Moonligthing microtubule-associated proteins: Regulatorí functions by day and pathological functions at night, J. Proteomics Bioinform 9: 11( Suppl) Roma, 2016 | Oláh J, Tripon RG, Nasir T, Csincsik L, Ovádi J, Lengyel I: The zinc-binding Tubulin Polymerization Promoting Protein TPPP/p25 in the retina, Zinc-UK, MC and CG Meeting, Belfast, United Kingdom, 2016 | Szénási T, Lehotzky A, Oláh J, Ovádi J: New therapic strategy in Parkinson’ research: Validation of drug target, Mol Life Febs3+Meeting Portoroz, 2015 | Oláh J, Szénási T, Szunyogh S, Szabó A, Lehotzky A, Ovádi J: Further evidence for microtubule-independent dimerization of TPPP/p25, Scientific Reports, 2017 | Lehotzky A, Oláh J, Szunyogh S, Szabó A, Berki T, Ovádi J.: The Zinc-induced structural rearrangement of the disordered TPPP/p25 promotes the decoration of the microtubule network: physiological and pathological relevancies, Zinc-Net Conference, London, UK, 2014 | Szunyogh S, Oláh J, Szénási T, Szabó A, Ovádi J.: Targeting the interface of the pathological complex of -synuclein and TPPP/p25, BBA MOLECULAR BASIS OF DISEASE 1852: pp. 2653-2661, 2015 | Ovádi J.: Progress in Development of Anti-parkinson Drug with Unique Specificity, J NEUROL EXP NEUROSCI 1:1, 2015 | Mangas-Sanjuan V, Oláh J, Gonzalez-Alvarez I, Lehotzky A, Tőkési N, Bermejo M, Ovádi J.: Tubulin Acetylation Promoting Potency and Absorption Efficacy of Deacetylase Inhibitors, BRITISH JOURNAL OF PHARMACOLOGY 172:829-840, 2015 | Lehotzky A, Oláh J, Szunyogh S, Szabó A, Berki T, Ovádi J.: Zinc-induced structural changes of the disordered TPPP/p25 inhibits its degradation by the proteasome, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852(1):83-91, 2015 | Oláh J, Norris V, Ovádi J.: Modeling of sensing potency of cytoskeletal systems decorated with metabolic enzymes, JOURNAL OF THEORETICAL BIOLOGY 36:190-196, 2015 | Tripon RG, Nasir T, Csincsik L, Olah J, Ovádi J, Lengyel I.: Immunolocalisation of Tubulin Polymerisation Promoter Protein TPPP/p25 in the retina, INVEST OPHTHALMOL VIS SCI 56(7):193, 2015 | Ádám Cs, Bőgel G, Fekete A, Németh Zs, Tőkési N, Ovádi J, Liliom K, Pesti Sz, Geiszt M, Buday L.: Accumulation of the PX domain mutant Frank-ter Haar syndrome protein Tks4 in aggresomes, CELL COMMUNICATION AND SIGNALING 13:33, 2015 | Zwick V, Nurisso A, Simões-Pires C, Bouchet S, Martinet N, Lehotzky A, OvadiJ, Cuendet M, Blanquart C, Bertrand P.: Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-prot, BIOORG MED CHEM LETT. 26(1):154, 2016 | Schiedel M, RumpfT, Karaman B, Lehotzky A, Oláh J, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung M.: Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study, J. MED. CHEM. Article ASAP DOI: 10.1021/acs.jmedchem.5b01517, 2016 | Schiedel M, Rumpf T, Karaman B, Lehotzky A, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung J: Structure-based Development of a Sirtuin 2 Affinity Probe, ANGEWANDTE CHEMIE COMMUNICATION, 2015 | Rumpf T, Schiedel S, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KJ, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, Schutkowski M, Sippl W, Einsle O, Jung M.: Selective Sirt2-inhibition by ligand induced rearrangement of the active site, NATURE COMMUNICATIONS 6: 6263, 2015 | Oláh J, Zotter Á, Hlavanda E, Szunyogh S, Orosz F, Szigeti K, Fidy J, Ovádi J.: Microtubule the oligomerization state of multiple equilibrium system from ITC data,, Biochimica et Biophysica Acta General Subject 1820, 785-94, 2012 | Norris V, Amar P, Legent G, Ripoll C, Thellier M, Ovádi J.: Sensor potency of the moonlighting enzyme-decorated cytoskeleton, BMC Biochemistry 14:3, 2013 | Oláh J, Tőkési N, Lehotzky A, Orosz F, Ovádi J.: MOONLIGHTING MICROTUBULE ASSOCIATED PROTEINS: Physiological functions by day and pathological functions at night, Cytoskeleton 70: pp. 677-685, 2013 | Oláh J , Tőkési N, Zotter A, Ovádi J.: Ultrastructure-derived physiological and pathological functions of the disordered TPPP/p25, Eur. Biophys. J. 42: (Suppl 1) p. S189, 2013 | Tőkési N, Oláh J, Hlavanda E, Szunyogh S, Szabó A, Babos F, Magyar A, Lehotzky A, Vass E, Ovádi J.: Identification of motives mediating alternative functions of the neomorphic moonlighting TPPP/p25, BBA-Mol. Basis Disease 1842: (4) pp. 547-557., 2014 | Ovádi J.: MOONLIGHTING MICROTUBULE ASSOCIATED PROTEINS, IX. Parnas Conference on Proteins from Birth to Death Jerusalem, 2013 | Ovádi J.: The neomorphic moonlighting disordered TPPP/p25 protein a key player of oligodendroglial maturation and etiology of distinct CNS diseases, 53rd Annual Meeting of the Japanese Society of Neurology Tokyo, 2012 | Ovádi J, Norris V: MOONLIGHTING FUNCTION OF THE TUBULIN CYTOSKELETON:Macromolecular architectures in the cytoplasm, Systems Biology of Metabolic and Signaling networks: energy, mass and information transfer Heidelberg; London; New York: Springer, pp. 165-179, 2014 | Ovádi J.: Macromolecular architectures in the cytoplasm derived by moonlighting proteins, Macromolecular crowding effects in cell biology: models and experiments Orleans, 2013 | Oláh J.: The Disordered TPPP/p25 Involved in Heteroassociations Of Hallmark Proteins Characteristic for Parkinson’s and Alzheimer’s Diseases., 5th Anniversary of Protein and Peptide Conference Peking, 2012 | Ovádi J.: Moonlighting TPPP/p25 mediates ultrastructure-controlled function of the microtubule cytoskeleton, EMBO-FEBS Meeting: Novel Biophysical Approaches in the Investigation of the Cytoskeleton Pécs, 2012 | Oláh J, Norris V, Ovádi J.: Modeling of sensing potency of cytoskeletal systems decorated with metabolic enzymes, J Theor Biol 36: 190–196, 2015 | Oláh J, Tőkési N, Szunyogh S, Szabó A, Lehotzky A, Ovádi J.: Tubulin Polymerization Promoting Protein is a prototype of neomorphic moonlighting proteins, Biological and Biomedical Consequences of Protein Moonlighting, London, UK, 2014 | Oláh J, Lehotzky A, Zotter A, Szunyogh S, Szabó A, Ovádi J.: The Zinc-induced structural rearrangement of the disordered TPPP/p25 promotes the decoration of the microtubule network: physiological and pathological relevancies, Zinc-Net Conference, London, UK, 2014 | Szunyogh S, Oláh J, Szénási T, Szabó A, Ovádi J.: Targeting the interface of the pathological complex of alpha-synuclein and TPPP/p25, BBA MOLECULAR BASIS OF DISEASE 1852: pp. 2653-2661, 2015 | Lehotzky A, Oláh J, Szunyogh S, Szabó A, Berki T, Ovádi J.: Zinc-induced structural changes of the disordered TPPP/p25 inhibits its degradation by the proteasome, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852(1):83-91, 2015 | Zwick V, Nurisso A, Simões-Pires C, Bouchet S, Martinet N, Lehotzky A, Ovadi J, Cuendet M, Blanquart C, Bertrand P.: Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-prot, BIOORG MED CHEM LETT. 26(1):154, 2016 | Schiedel M, RumpfT, Karaman B, Lehotzky A, Oláh J, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung M.: Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study, J. MED. CHEM. 59: 1599-1612, 2016 | Schiedel M, Rumpf T, Karaman B, Lehotzky A, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung J: Structure-based Development of a Sirtuin 2 Affinity Probe, ANGEWANDTE CHEMIE Int ed, 55: 2252-2256, 2016 | S. Szunyogh, J. Oláh, A. Lehotzky, and J. Ovádi: The disordered tppp/p25, a prototype of the neomorphic moonlighting proteins, 12th Greta Pifat Mrzljak International School of Biophysics, Primošten, Croatia, 2014 | Oláh J. Szunyogh S, Lehotzky A, Ovádi J.: Tubulin Polymerization Promoting Protein is a prototype of neomorphic moonlighting proteins, Biological and Biomedical Consequences of Protein Moonlighting, London, UK, 2014 | Ovádi J.: Macromolecular architectures in the cytoplasm derived by moonlighting proteins, Macromolecular crowding effects in cell biology: models and experiments Orleans, 2013 | Oláh J.: The Disordered TPPP/p25 Involved in Heteroassociations Of Hallmark Proteins Characteristic for Parkinson’s and Alzheimer’s Diseases., 5th Anniversary of Protein and Peptide Conference Peking, 2013 | Tőkési A, Lehotzky A, Oláh J, Ovádi J.: Distinct function of TPPP/p25 in development and disease, Barcelona, 2013 | Ovádi J.: Moonlighting TPPP/p25 mediates ultrastructure-controlled function of the microtubule cytoskeleton, EMBO-FEBS Meeting: Novel Biophysical Approaches in the Investigation of the Cytoskeleton Pécs, 2012 | Tőkési N, Oláh J, Hlavanda E, Szunyogh S, Szabó A, Babos F, Magyar A, Lehotzky A, Vass E, Ovádi J.: Identification of motives mediating alternative functions of the neomorphic moonlighting TPPP/p25, Biochim Biophys Acta Molec Dis. 2014 Apr;1842(4):547-57., 2014 | Oláh J, Norris V, Ovádi J.: Modeling of sensing potency of cytoskeletal systems decorated with metabolic enzymes, J Theor Biol 365. 190–196, 2014 | Ovádi J, Norris V: Moonlighting function of the tubulin cytoskeleton: macromolecular architectures in the cytoplasm, Systems Biology of Metabolic and Signaling networks: energy, mass and information transfer New York: Springer Verlag,, 2014 | Oláh J and Ovádi J.: Dual life of TPPP/p25 evolved in physiological and pathological conditions, Biochem Soc Trans. 42, 1762-1767, 2014 | Oláh J, Zotter Á, Hlavanda E, Szunyogh S, Orosz F, Szigeti K, Fidy J, Ovádi J.: Microtubule the oligomerization state of multiple equilibrium system from ITC data,, Biochimica et Biophysica Acta General Subject 1820, 785-94, 2012 | Orosz F.: A new protein superfamily: TPPP-like proteins, PLOS ONE 7(11) p. e49276. 14 p, 2012 | Orosz F.: A Fish-specific Member of the TPPP Protein Family?, J. Mol. Evol. 75:(1-2) pp. 55-72, 2012 | Norris V, Amar P, Legent G, Ripoll C, Thellier M, Ovádi J.: Sensor potency of the moonlighting enzyme-decorated cytoskeleton, BMC Biochemistry in press, 2012 | Ovádi J. and Norris V.: Moonlighting function of the tubulin cytoskeleton: Macromolecular architectures in the cytoplasm, Springer in press, 2013 | Orosz F.: A new protein superfamily: TPPP-like proteins, PLOS ONE 7(11) p. e49276. 14 p, 2012 | Orosz F.: A Fish-specific Member of the TPPP Protein Family?, J. Mol. Evol. 75:(1-2) pp. 55-72, 2012 | Norris V, Amar P, Legent G, Ripoll C, Thellier M, Ovádi J.: Sensor potency of the moonlighting enzyme-decorated cytoskeleton, BMC Biochemistry in press, 2013 | Oláh J, Tőkési N, Lehotzky A, Orosz F, Ovádi J.: MOONLIGHTING MICROTUBULE ASSOCIATED PROTEINS: Physiological functions by day and pathological functions at night, Cytoskeleton, 2013 | Oláh J , Tőkési N, Zotter A, Ovádi J.: Ultrastructure-derived physiological and pathological functions of the disordered TPPP/p25, Eur. Biophys. J, 2013 | Tőkési N, Oláh J, Hlavanda E, Szunyogh S, Szabó A, Babos F, Magyar A, Lehotzky A, Vass E, Ovádi J.: Identification of motives mediating alternative functions of the neomorphic moonlighting TPPP/p25, BBA-Mol. Basis Disease, 2014 | Oláh J, Zotter Á, Hlavanda E, Szunyogh S, Orosz F, Szigeti K, Fidy J, Ovádi J.: Microtubule assembly-derived by dimerization of TPPP/p25: Evaluation of thermodynamic parameters for multiple equilibrium system from ITC data, BBA-GENERAL SUBJECTS, 2012 | Ovádi J.: MOONLIGHTING MICROTUBULE ASSOCIATED PROTEINS, IX. Parnas Conference on Proteins from Birth to Death Jerusalem, 2013 | Ovádi J.: The neomorfic moonlighting disordered TPPP/p25 protein a key player of oligodendroglial maturation and etiology of distinct CNS diseases, 53rd Annual Meeting of the Japanese Society of Neurology Tokyo, 2012 | Ovádi J, Norris V: MOONLIGHTING FUNCTION OF THE TUBULIN CYTOSKELETON:Macromolecular architectures in the cytoplasm, Systems Biology of Metabolic and Signaling networks: energy, mass and information transfer, 2013 |
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