![](img/space.gif) |
Újonnan szintetizált nitrogént tartalmazó szteroidok emlőkarcinóma-ellenes hatásának vizsgálata in vitro és in vivo
|
súgó
nyomtatás
|
Ezen az oldalon az NKFI Elektronikus Pályázatkezelő Rendszerében nyilvánosságra hozott projektjeit tekintheti meg.
vissza »![](img/space.gif)
![](img/space.gif)
![](img/space.gif)
![](img/space.gif)
|
![](img/print_ver.gif) |
Közleményjegyzék |
|
|
Fröhlich T, Kiss A, Wölfling J, Mernyák E, Kulmány Á, Minorics R, Zupkó I, Leidenberger M, Friedrich O, Kappes B, Hahn F, Marschall M, Schneider G, Tsogoeva SB: Synthesis of artemisinin-estrogen hybrids highly active against HCMV, P. falciparum, and cervical and breast cancer, ACS Med Chem Lett 9: 1128-33, 2018 | Gyovai A, Minorics R, Kiss A, Mernyák E, Schneider G, Szekeres A, Kerekes E, Ocsovszki I, Zupkó I: Antiproliferative properties of newly synthesized 19-nortestosterone analogs without substantial androgenic activity, Front Pharmacol 9: 825, 2018 | Le T, Bérdi P, Zupkó I, Fülöp F, Szakonyi Z: Synthesis and transformation of (-)-isopulegol-based chiral b-aminolactones and b-aminoamides, Int J Mol Sci 19: 3522, 2018 | Minorics R, Zupkó I: Steroidal anticancer agents: An overview of estradiol-related compounds., Anticancer Agents Med Chem 18: 652-66, 2018 | Sinka I, Kiss A, Mernyák E, Wölfling J, Schneider G, Ocsovszki I, Kuo CY, Wang HC, Zupkó I: Antiproliferative and antimetastatic properties of 3-benzyloxy-16-hydroxymethylene-estradiol analogs against breast cancer cell lines, Eur J Pharm Sci 123: 362-70, 2018 | Zupkó István: Természetes vegyületek és szintetikus szteroid analógok antiproliferatív hatásának vizsgálata, Magyar Tudományos Akadémia - MTA doktori értekezés, 2016 | Baji Á, Gyovai A, Wölfling J, Minorics R, Ocsovszki I, Zupkó I, Frank É: Microwave-assisted one-pot synthesis of steroid-quinoline hybrids and an evaluation of their antiproliferative activities on gynecological cancer cell lines, RSC Adv 6: 27501-16, 2016 | Bodnár B, Mernyák E, Wölfling J, Schneider G, Herman EB, Szécsi M, Sinka I, Zupkó I, Kupihár Z, Kovács L: Synthesis and biological evaluation of triazolyl 13a-estrone-nucleoside bioconjugates, Molecules 21: 1212, 2016 | Kovács D, Wölfling J, Szabó N, Szécsi M, Schelz Z, Zupkó I, Frank É: Synthesis of novel 17-(4'-formyl)pyrazolylandrosta-5,16-dienes and their derivatives as potent 17a-hydroxylase/C17,20-lyase inhibitors or antiproliferative agents dependi, Eur J Med Chem 120: 284-95, 2016 | Molnár J, Szebeni JG, Csupor-Löffler B, Hajdú Z, Szekeres T, Saiko P, Ocsovszki I, Puskás GL, Hohmann J, Zupkó I: Investigation of the antiproliferative properties of natural sesquiterpenes from Artemisia asiatica and Onopordum acanthium on HL-60 cells in vitro, Int J Mol Sci 17: 83, 2016 | Mótyán G, Baji Á, Zupkó I, Frank É: Regio- and stereoselective synthesis of pregnane-fused isoxazolines by nitril-oxide/alkene 1,3-dipolar cycloaddition and an evaluation of their cell-growth inhibitory eff, J Mol Struct 1110: 143-9, 2016 | Mótyán G, Kovács F, Wölfling J, Gyovai A, Zupkó I, Frank É: Microwave-assisted stereoselective approach to novel steroidal ring D-fused 2-pyrazolines and an evaluation of their cell-growth inhibitory effects in vitro, Steroids 112: 36-46, 2016 | Schelz Z, Ocsovszki I, Bózsity N, Hohmann J, Zupkó I: Antiproliferative effects of various furanoacridones isolated from Ruta graveolens on human breast cancer cell lines, Anticancer Res 36: 2751-8, 2016 | Schneider G, Kiss A, Mernyák E, Benke Z, Wölfling J, Frank É, Bózsity N, Gyovai A, Minorics R, Zupkó I: Stereocontrolled synthesis of the four 16-hydroxymethyl-19-nortestosterone isomers and their antiproliferative activities, Steroids 105: 113-20, 2016 | Szabó J, Bacsa I, Wölfling J, Schneider G, Zupkó I, Varga M, Herman BE, Kalmár L, Szécsi M, Mernyák E: Synthesis and in vitro pharmacological evaluation of N-[(1-benzyl-1,2,3-triazol-4-yl)methyl]-carboxamides on d-secoestrone scaffolds, J Enzyme Inhib Med Chem 31: 574-9, 2016 | Szabó J, Jerkovics N, Schneider G, Wölfling J, Bózsity N, Minorics R, Zupkó I, Mernyák E: Synthesis and in vitro antiproliferative evaluation of C-13 epimers of triazolyl-D-secoestrone alcohols: The first potent 13a-D-secoestrone derivative, Molecules 21: 611, 2016 | Szabó J, Pataki Z, Wölfling J, Schneider G, Bózsity N, Minorics R, Zupkó I, Mernyák E: Synthesis and biological evaluation of 13a-estrone derivatives as potential antiproliferative agents, Steroids 113: 14-21, 2016 | Bózsity N, Minorics R, Szabó J, Mernyák E, Schneider G, Wölfling J, Wang HC, Wu CC, Ocsovszki I, Zupkó I: Mechanism of antiproliferative action of a new d-secoestrone-triazole derivative in cervical cancer cells and its effect on cancer cell motility, J Steroid Biochem Mol Biol 165: 247-57, 2017 | Gyovai A, Minorics R, Bózsity N, Schneider G, Ocsovszki I, Kiss A, Zupkó I: 19-Nortesztoszteron származékok antiproliferatív hatása humán malignus sejtvonalakon, Magyar Élettani Társaság 80. Vándorgyűlése, Pécs, 2016 | Izabella Sinka, Ida Kovács, Erzsébet Mernyák, Imre Ocsovszki, Gyula Schneider, János Wölfling, István Zupkó: Investigation of antiproliferative properties of 13α-estrone derivatives in vitro, International Bioscience Conference and the 6th International PSU – UNS Bioscience Conference, Novi Sad, Serbia, 2016 | Noémi Bózsity, Viktória Nagy, Erzsébet Mernyák, Johanna Szabó, János Wölfling, István Zupkó: New antiproliferative estrone dimer derivative, International Bioscience Conference and the 6th International PSU – UNS Bioscience Conference, Novi Sad, Serbia, 2016 | András Gyovai, Renáta Minorics, Noémi Bózsity, Anita Kiss, Imre Ocsovszki, Gyula Schneider, István Zupkó: Antiproliferative effect of 19-nortestosterone analogues on gynecological cancer cell lines, International Bioscience Conference and the 6th International PSU – UNS Bioscience Conference, Novi Sad, Serbia, 2016 | Bodnár B, Mernyák E, Wölfling J, Zupkó I, Kupihár Z: Synthesis of nucleoside-estrone bioconjugates applying copper catalyzed alkine azide click reaction, 8th Central European Conference “Chemistry towards Biology“, Brno, Czech Republic, 2016 | Kulmány Á, Kiss A, Zupkó I, Minorics R, Ocsovszki I: Anticancer properties of sesquiterpene derivatives and their conjugates with estrogens on breast cancer cell lines, Acta Pharm Hung 87: 215 (2017), 2017 | Gyovai A, Bózsity N, Minorics R, Benke Z, Ocsovszki I, Schneider G, Zupkó I: In vitro antiproliferative properties of novel androstane-based synthetic steroids, Acta Pharm Hung 87: 214-5 (2017), 2017 | Sinka I, Mernyák E, Kiss A, Schneider G, Wölfling J, Ocsovszki I, Kuo CY, Wang HC, Zupkó I: Investigation of anticancer properties of D-ring modified estrane analogs against a panel of breast cancer cell lines, Acta Pharm Hung 87: 213-4 (2017), 2017 | Gyovai A, Minorics R, Bózsity N, Kiss A, Benke Z, Mernyák E, Ocsovszki I, Schneider G, Zupkó I: In vitro anticancer activity of novel androstane-based synthetic steroids, 3rd International Cancer Symposium of the Cancer Research Center of Lyon, Lyon, France, 2017. IX. 25-27., 2017 | Sinka I, Kiss A, Mernyák E, Schneider G, Ocsovszki I, Kuo CY, Wang HC, Zupkó I: Investigation of antiproliferative and antimetastatic properties of estrane analogs modified in D-ring against breast cancer cell lines, 3rd International Cancer Symposium of the Cancer Research Center of Lyon, Lyon, France, 2017. IX. 25-27., 2017 | Vasas A, Lajter I, Forgó P, Kúsz N, Bózsity N, Zupkó I, Nagy N, Krupitza G, Frish R, Hohmann J: Sesquiterpenes from Neurolaena lobata with antiproliferative activity, Planta Med Int Open 4: S38 (2017), 2017 | Vágvölgyi M, Martins A, Kulmány Á, Zupkó I, Gáti T, Simon A, Tóth G, Hunyadi A: Nitrogen-containing ecdysteroid derivatives vs. multi-drug resistance in cancer: Preparation and antitumor activity of oximes, oxime ethers and a lactam, Eur J Med Chem 144: 730-9 (2018), 2018 | Gonda T, Bérdi P, Zupkó I, Fülöp F, Szakonyi Z: Stereoselective synthesis, synthetic and pharmacological application of monoterpene-based 1,2,4- and 1,3,4-oxadiazoles, Int J Mol Sci 19: 81 (2018), 2018 | Szakonyi Z, Zupkó I, Fülöp F: Stereoselective synthesis and antiproliferative activity of monoterpene-fused 2-imino-1,3-oxazines, Curr Org Synth 14: 612-9 (2017), 2017 | Bodnár B, Mernyák E, Szabó J, Wölfling J, Schneider G, Zupkó I, Kupihár Z, Kovács L: Synthesis and in vitro investigation of potential antiproliferative monosaccharide-D-secoestrone bioconjugates, Bioorg Med Chem Lett 27: 1938-42 (2017), 2017 | Baji Á, Kovács F, Mótyán G, Schneider G, Wölfling J, Sinka I, Zupkó I, Ocsovszki I, Frank E: Investigation of pH and substituent effects on the distribution ratio of novel steroidal ring D- and A-fused arylpyrazole regioisomers and evaluation of their cell-growth, Steroids 126: 35-49 (2017), 2017 | Tóth B, Kúsz N, Forgo P, Bózsity N, Zupkó I, Pinke G, Hohmann J, Vasas A: Abietane diterpenoids from Sideritis montana L. and their antiproliferative activity, Fitoterapia 122: 90-4 (2017), 2017 | Vágvölgyi M, Martins A, Kulmány Á, Zupkó I, Gáti T, Simon A, Tóth G, Hunyadi A: Nitrogen-containing ecdysteroid derivatives vs. multi-drug resistance in cancer: Preparation and antitumor activity of oximes, oxime ethers and a lactam, EUR J MED CHEM 144: 730-739, 2018 | Baji Á, Kovács F, Mótyán G, Schneider G, Wölfling J, Sinka I, Zupkó I, Ocsovszki I, Frank É: Investigation of pH and substituent effects on the distribution ratio of novel steroidal ring D- and A-fused arylpyrazole regioisomers and evaluation of their cell-growth inhibitory effects in vitro, STEROIDS 126: 35-49, 2017 | Bózsity Noémi, Minorics Renáta, Szabó Johanna, Mernyák Erzsébet, Schneider Gyula, Wölfling János, Wang Hui-Chun, Wu Chin-Chung, Ocsovszki Imre, Zupkó István: Mechanism of antiproliferative action of a new D-secoestrone-triazole derivative in cervical cancer cells and its effect on cancer cell motility, J STEROID BIOCHEM MOL BIOL 165: 247-257, 2017 | Szabo J, Jerkovics N, Schneider G, Wolfling J, Bozsity N, Minorics R, Zupko I, Mernyak E: Synthesis and in Vitro Antiproliferative Evaluation of C-13 Epimers of Triazolyl-d-Secoestrone Alcohols: The First Potent 13alpha-d-Secoestrone Derivative., MOLECULES 21: (5) , 2016 | Szabó Johanna, Bacsa Ildikó, Wölfling János, Schneider Gyula, Zupkó István, Varga Mónika, Herman Bianka E, Kalmár László, Szécsi Mihály, Mernyák Erzsébet: Synthesis and in vitro pharmacological evaluation of N-[(1-benzyl-1,2,3-triazol-4-yl)methyl]-carboxamides on d-secoestrone scaffolds, J ENZYM INHIB MED CH 31: (4) 574-579, 2016 | Mernyák Erzsébet, Kovács Ida, Minorics Renáta, Sere Péter, Czégány Dóra, Sinka Izabella, Wölfling János, Schneider Gyula, Újfaludi Zsuzsanna, Boros Imre, Ocsovszki Imre, Varga Mónika, Zupkó István: Synthesis of trans-16-triazolyl-13α-methyl-17-estradiol diastereomers and the effects of structural modifications on their in vitro antiproliferative activities, J STEROID BIOCHEM MOL BIOL 150: 123-134, 2015 | Minorics Renáta, Bózsity Noémi, Molnár Judit, Wölfling János, Mernyák Erzsébet, Schneider Gyula, Ocsovszki Imre, Zupkó István: A molecular understanding of d-homoestrone-induced G2/M cell cycle arrest in HeLa human cervical carcinoma cells, J CELL MOL MED 19: (10) 2365-2374, 2015 | Molnár Judit, Frank Éva, Minorics Renáta, Kádár Zalán, Ocsovszki Imre, Schönecker Bruno, Wölfling János, Zupkó István: A Click Approach to Novel D-Ring-Substituted 16α-Triazolylestrone Derivatives and Characterization of Their Antiproliferative Properties, PLOS ONE 10: (2) e0118104, 2015 | Mernyák Erzsébet, Fiser Gabriella, Szabó Johanna, Bodnár Brigitta, Schneider Gyula, Kovács Ida, Ocsovszki Imre, Zupkó István, Wölfling János: Synthesis and in vitro antiproliferative evaluation of D-secooxime derivatives of 13β- and 13α-estrone, STEROIDS 89: 47-55, 2014 | Zupko I, Molnar J, Rethy B, Minorics R, Frank E, Wolfling J, Molnar J, Ocsovszki I, Topcu Z, Bito T, Puskas LG: Anticancer and multidrug resistance-reversal effects of solanidine analogs synthetized from pregnadienolone acetate., MOLECULES 19: (2) 2061-2076, 2014 | Mernyák E, Fiser G, Szabó J, Bodnár B, Schneider G, Kovács I, Ocsovszki I, Zupkó I, Wölfling J: Synthesis and in vitro antiproliferative evaluation of d-secooxime derivatives of 13b- and 13a-estrone, Steroids 89: 47-55, 2014 | Mernyák E, Szabó J, Bacsa I, Huber J, Schneider G, Minorics R, Bózsity N, Zupkó I, Varga M, Bikádi Z, Hazai E, Wölfling J: Syntheses and antiproliferative effects of d-homo- and d-secoestrones, Steroids 87: 128-36, 2014 | Frank É, Kovács D, Schneider G, Wölfling J, Bartók T, Zupkó I: Synthesis of novel steroidal 16-spiroisoxazolines by 1,3-dipolar cycloaddition, and an evaluation of their antiproliferative activities in vitro, Mol Divers 18: 521-34, 2014 | Kovács D, Mótyán G, Wölfling J, Kovács I, Zupkó I, Frank É: A facile access to novel steroidal 17-2'-(1',3',4')-oxadiazoles, and an evaluation of their cytotoxic activities in vitro, Bioorg Med Chem Lett 24: 1265-8, 2014 | Zupkó I, Molnár J, Réthy B, Minorics R, Frank É, Wölfling J, Molnár J, Ocsovszki I, Topcu Z, Bitó T, Puskás GL: Anticancer and multidrug resistance-reversal effects of solanidine analogs synthetized from pregnadienolone acetate, Molecules 19: 2061-76, 2014 | Molnár J, Frank É, Minorics R, Kádár Z, Ocsovszki I, Schönecker B, Wölfling J, Zupkó I: A click approach to novel D-ring-substituted 16-triazolylestrone derivatives and characterization of their antiproliferative properties, Plos One, In press, 2015 | Szakonyi Z, Zupkó I, Sillanpää R, Fülöp F: Stereoselective synthesis and cytoselective toxicity of monoterpene-fused 2-imino-1,3-thiazines, Molecules 19: 15918-37, 2014 | Hajdú Z, Hohmann J, Forgo P, Máthé I, Molnár J, Zupkó I: Antiproliferative activity of Artemisia asiatica extract and its constituents on human tumor cell lines, Planta Med 80: 1692-7, 2014 | Szabó J, Bodnár B, Wölfling J, Schneider G, Zupkó I, Mernyák E: Preparation of novel cytostatic D-secoestrone conjugates [P-62], 20th International Conference on Organic Synthesis, Budapest, Hungary, 2014 | Szabó J, Bacsa I, Wölfling J, Schneider G, Zupkó I, Mernyák E: Synthesis of novel antoproliferative D-secoalkynes of 13a- and 13b-estrone and their heterocyclic derivatives [P-106], 20th International Conference on Organic Synthesis, Budapest, Hungary, 2014 | Bózsity N, Gyovai A, Minorics R, Benke Z, Mernyák E, Wölfling J, Schneider G, Zupkó I: 19-Nortesztoszteron származékok antiproliferatív hatása: mechanizmus és szerkezet-hatás összefüggések [P-79], Congressus Pharmaceuticus Hungaricus XV., Budapest, 2014 | Berényi Á, Zupkó I: Ösztron származékok és nemszteroid 17b-hidroxiszteroid-dehidrogenáz-1 gátlók tumorellenes hatásának vitsgálata, Vajdasági Magyar Tudóstalálkozó 2014, Újvidék, 2014 | Molnár J, Frank É, Minorics R, Kádár Z, Ocsovszki I, Schönecker B, Wölfling J, Zupkó I: A click approach to novel D-ring-substituted 16-triazolylestrone derivatives and characterization of their antiproliferative properties, Plos One, 10: e0118104, 2015 | Huber J, Wölfling J, Schneider G, Ocsovszki I, Varga M, Zupkó I, Mernyák E: Synthesis of antiproliferative 13a-d-homoestrones via lewis acid-promoted one-pot prins-ritter reactions of d-secosteroidal d-alkenyl-aldehydes, Steroids 102:76-84, 2015 | Kovács D, Wölfling J, Szabó N, Szécsi M, Minorics R, Zupkó I, Frank É: Efficient access to novel androsteno-17-(1',3',4')-oxadiazoles and 17b-(1',3',4')-thiadiazoles via n-substituted hydrazone and n,n'-disubstituted hydrazine intermediates,, Eur J Med Chem 98: 13-29, 2015 | Mernyák E, Kovács I, Minorics R, Sere P, Czégány D, Sinka I, Wölfling J, Schneider G, Újfaludi Z, Boros I, Ocsovszki I, Varga M, Zupkó I: Synthesis of trans-16-triazolyl-13a-methyl-17-estradiol diastereomers and the effects of structural modifications on their in vitro antiproliferative activities, J Steroid Biochem Mol Biol 150: 123-134, 2015 | Minorics R, Bózsity N, Molnár J, Wölfling J, Mernyák E, Schneider G, Ocsovszki I, Zupkó I: A molecular understanding of d-homoestrone-induced g2/m cell cycle arrest in hela human cervical carcinoma cells, J Cell Mol Med 19: 2365-2374, 2015 | Mótyán G, Zupkó I, Minorics R, Schneider G, Wölfling J, Frank É: Lewis acid-induced intramolecular access to novel steroidal ring d-condensed arylpyrazolines exerting in vitro cell-growth-inhibitory effects, Mol Divers 19: 511-527, 2015 | Schneider G, Görbe T, Mernyák E, Wölfling J, Holczbauer T, Czugler M, Sohár P, Minorics R, Zupkó I: Synthesis of novel 17-(5'-iodo)triazolyl-3-methoxyestrane epimers via cu(i)-catalyzed azide-alkyne cycloadditon, and an evaluation of their cytotoxic activity in vitro, Steroids 98: 153-165, 2015 | Szabó N, Iványi Z, Szécsi M, Julesz J, Mernyák E, Huber J, Wölfling J, Minorics R, Zupkó I, Schneider G: Synthesis of methoxycarbonylpyrazolylandrostene derivatives, and their potential inhibitory effect on androgen biosynthesis and cell proliferation, Steroids 98: 143-152, 2015 | Bózsity N, Minorics R, Mernyák E, Szabó J, Schneider G, Wölfling J, Wang HC, Wu CC, Zupkó I: D-secoestrone-triazol: A new secoestrone derivative with antiproliferative and antimigration effects in cervical cancer cells, 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine. Athens, Greece: Int J Mol Med 2015:S113., 2015 | Frank É, Kovács D, Wölfling J, Zupkó I, Szécsi M: 17-exo-heterociklusos szteroidok elõállítása és in vitro farmakológiai hatásai, MKE 2. Nemzeti Konferencia, 2015 | Zupkó I, Gyovai A, Baji Á, Ocsovszki I, Minorics R, Frank É: Antiproliferative properties of ring a-fused steroidal quinolines in vitro, 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine. Athens, Greece: Int J Mol Med 2015:S113., 2015 | Minorics R, Bózsity N, Gyovai A, Mernyák E, Wölfling J, Schneider G, Zupkó I: Specific antiproliferative effect of 17-alpha-19-nortestosterone and its analogue in HeLa cells, 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine. Int J Mol Med, Athens, Greece, pp. S112, 2015 |
![](img/space.gif)
|
|
|
![](img/shadow_right_up.gif)
|
![](img/shadow_left_bottom.gif)
|
![](img/shadow_right_bottom.gif)
|
![](img/space.gif)
vissza »
|
![](img/space.gif) |
|