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SPINK1 mutációk molekuláris patomechanizmusa pancreatitisben
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Ezen az oldalon az NKFI Elektronikus Pályázatkezelő Rendszerében nyilvánosságra hozott projektjeit tekintheti meg.
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Toldi Vanda, Kassay Norbert, Szabó András: Missense PNLIP mutations impeding pancreatic lipase secretion cause protein misfolding and endoplasmic reticulum stress, PANCREATOLOGY [Epub ahead of print]:, 2021 | Norbert Kassay, Vanda Toldi, József Tőzsér, András Szabó: Cigarette smoke toxin hydroquinone and misfolding pancreatic lipase variant cooperatively promote endoplasmic reticulum stress and cell death, PLoS One 17(6):e0269936, 2022 | Toldi Vanda, Szabó András, Sahin-Tóth Miklós: Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation, JOURNAL OF BIOLOGICAL CHEMISTRY 295: (11) pp. 3447-3455., 2020 | Szabó András, Toldi Vanda, Gazda Lívia Diána, Demcsák Alexandra, Tőzsér József, Sahin-Tóth Miklós: Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis, JOURNAL OF BIOLOGICAL CHEMISTRY 296: 100343, 2021 | Szabó András, Toldi Vanda, Gazda Lívia Diána, Demcsák Alexandra, Tőzsér József, Sahin-Tóth Miklós: Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis, J. Biol. Chem., under review, 2021 | Esteghamat Fatemehsadat, Broughton James S, Smith Emily, Cardone Rebecca, Tyagi Tarun, Guerra Mateus, Szabó András, Ugwu Nelson, Mani Mitra V, Azari Bani, Kayingo Gerald, Chung Sunny, Fathzadeh Mohsen, Weiss Ephraim, Bender Jeffrey, Mane Shrikant, Lifton Richard P, Adeniran Adebowale, Nathanson Michael H, Gorelick Fred S, Hwa John, Sahin-Tóth Miklós, Belfort-DeAguiar Renata, Kibbey Richard G, Mani Arya: CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation., NATURE GENETICS 51: (8) pp. 1233-1243., 2019 | Lasher Denise, Szabo Andras, Masamune Atsushi, Chen Jian-Min, Xiao Xunjun, Whitcomb David C., Barmada M. Michael, Ewers Maren, Ruffert Claudia, Paliwal Sumit, Issarapu Prachand, Bhaskar Seema, Mani K. Radha, Chandak Giriraj R., Laumen Helmut, Masson Emmanuelle, Kume Kiyoshi, Hamada Shin, Nakano Eriko, Seltsam Katharina, Bugert Peter, Mueller Thomas, Groneberg David A., Shimosegawa Tooru, Rosendahl Jonas, Ferec Claude, Lowe Mark E., Witt Heiko, Sahin-Toth Miklos: Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis, AMERICAN JOURNAL OF GASTROENTEROLOGY 114: (6) pp. 974-983., 2019 | Toldi Vanda, Szabó András, Sahin-Tóth Miklós: Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation, JOURNAL OF BIOLOGICAL CHEMISTRY 295: (11) pp. 3447-3455., 2020 | András Szabó, Vanda Toldi, Miklós Sahin-Tóth: Proteolytic inactivation of mesotrypsin by chymotrypsin C protects SPINK1 from degradation, Pancreatology 19, S1-S180, P1-14, 2019 | Morales Granda Nataly C., Toldi Vanda, Miczi Márió, Lassoued Meriam, Szabó András: Inhibition of mouse trypsin isoforms by SPINK1 and effect of human pancreatitis-associated mutations, PANCREATOLOGY, 2023 |
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