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A humán ABCG2 multidrog transzporter működésének vizsgálata
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súgó
nyomtatás
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Ezen az oldalon az NKFI Elektronikus Pályázatkezelő Rendszerében nyilvánosságra hozott projektjeit tekintheti meg.
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Közleményjegyzék |
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Hegedus C, Ozvegy-Laczka C, Apati A, Magocsi M, Német K, Orfi L, Keri G, Katona M, Takats Z, Varadi A, Szakacs G, Sarkadi B.: Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties, Brit J Pharmacol (nyomtatás alatt), 2009 | Hegedus C, Ozvegy-Laczka C., Szakacs G., and Sarkadi B.: Interaction of anticancer protein kinase inhibitors with ABC multidrug transporters: substrates and/or inhibitors?, Current Cancer Drug Targets, 9:252-72., 2009 | Ozvegy-Laczka C, Laczko R, Hegedus C, Litman T, Varady G, Goda K, Hegedus T, Dokholyan NV, Sorrentino BP, Varadi A, Sarkadi B.: Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter., J Biol Chem. 283, 26059-26070., 2008 | Szakacs G, Varadi A, Ozvegy-Laczka C, Sarkadi B.: The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox)., Drug Discovery Today 13, 379-393, 2008 | Orban TI, Seres L, Ozvegy-Laczka C, Elkind NB, Sarkadi B, Homolya L.: Combined localization and real-time functional studies using a GFP-tagged ABCG2 multidrug transporter., Biophys. Res. Commun. 14, 667-73., 2008 | Telbisz A, Muller M, Ozvegy-Laczka C, Homolya L, Szente L, Varadi A, Sarkadi B.: Membrane cholesterol selectively modulates the activity of the human ABCG2 multidrug transporter., Biochim Biophys Acta. 1768, 2698-713, 2007 | Cervenak, J., Andrikovics, H., Ozvegy-Laczka, C., Tordai, A., Nemet, K., Varadi, A., Sarkadi, B.: The role of the human ABCG2 multidrug transporter and its variants in cancer therapy and toxicology., Cancer Lett. 234, 62-72., 2006 | Morisaki, K., Robey, R. W., Ozvegy-Laczka, C., Honjo, Y., Polgar, O., Steadman, K., Sarkadi, B., Bates, S. E.: Single nucleotide polymorphisms modify the transporter activity of ABCG2, Cancer Chemoth. Pharm. 56, 161-172, 2005 | Ozvegy-Laczka, C., Cserepes, J., Elkind, N. B., Sarkadi, B.: Tyrosine kinase inhibitor resistance in cancer: Role of ABC multidrug transporters, Drug Resist. Updat. 8, 15-26, 2005 | Elkind, N. B., Szentpetery, Zs., Apati, A., Ozvegy-Laczka, C., Varady, Gy., Ujhelly, O., Szabo, K., Homolya, L., Varadi, A., Buday, L., Keri, Gy., Nemet, K., Sarkadi, B.: The multidrug transporter ABCG2 prevents tumor cell death induced by the EGF receptor inhibitor Iressa (Gefitinib, ZD1839), Cancer Res. 65, 1770-1777, 2005 | Ozvegy-Laczka, C., Varady, Gy., Koblos, G., Ujhelly, O., Cervenak, J., Schuetz, J. D., Sorrentino, B. P., Koomen, G.-J., Varadi, A., Nemet, K., Sarkadi, B.: Function dependent conformational changes of the ABCG2 multidrug transporter modify its interaction with a monoclonal antibody on the cell surface., J. Biol. Chem. 280, 4219-4227, 2005 | Ozvegy-Laczka, C., Koblos, G., Sarkadi, B., Varadi, A.: Single amino acid (R482) mutant variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition., Biochim. Biophys. Acta 1668, 53-63, 2005 | Sarkadi, B., Ozvegy-Laczka, C., Nemet, K., Varadi, A. (2004): ABCG2 -A Transporter for all seasons., FEBS Letters 567, 116-120, 2004 | Ozvegy-Laczka, C., Hegedus, T., Varady, Gy., Ujhelly, O., Schuetz, J., D., Varadi, A., Keri, Gy., Orfi, L., Nemet, K., Sarkadi, B.: High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter, Mol. Pharmacol. 65, 1485-1495, 2004 | Cserepes, J., Szentpetery, Zs., Seres, L., Ozvegy-Laczka, C., Langmann, T., Schmitz, G., Glavinas, H., Klein, .I, Homolya, L., Varadi, A., Sarkadi, B., Elkind, N. B.: Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization., Biochem. Biophys. Res. Commun. 320, 860-867, 2004 |
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