Mathematical modelling of clinical observations for improved melanoma detection

Help

Back »

Details of project

Identifier

101680

Type

Principal investigator

Hajdu, Lajos

Title in Hungarian

Klinikai megfigyelések matematikai modellezése a melanoma hatékonyabb detektálásához

Title in English

Mathematical modelling of clinical observations for improved melanoma detection

Keywords in Hungarian

melanoma felismerése, matematikai modellezés, digitális képfeldolgozás, klinikai szűrés

Keywords in English

melanoma detection, mathematical modelling, digital image processing, clinical screening

Discipline

Mathematics (Council of Physical Sciences)	70 %
Ortelius classification: Applied mathematics
Information Technology (Council of Physical Sciences)	20 %
Ortelius classification: Medical informatics
Medical engineering and technology (Council of Medical and Biological Sciences)	10 %

Panel

Natural Sciences Committee Chairs

Department or equivalent

Institute of Mathematics (University of Debrecen)

Participants

Baran, Sándor
Emri, Gabriella
Fazekas, Attila
Hajdu, András
Juhász, István
Kapitány, Miklós
Lázár, István
Páles, Zsolt
Pintér, Ákos
Szakács, József
Tóth, János

Starting date

2012-01-01

Closing date

2015-06-30

Funding (in million HUF)

53.240

FTE (full time equivalent)

10.14

state

closed project

Summary in Hungarian

A tervezett kutatás egy napjainkban igen fontos területre, a melanoma detektálásának hatékonyabbá tételére összpontosít. A kutatócsoport létrejöttét az a cél is motiválta, hogy egy társadalmilag igen fontos problémához elméleti mélységű támogatást biztosítsunk. Korábbi tapasztalataink alapján a klinikai és műszaki tudományok területén gyakran hiányzik ez a háttér, melynek megléte várhatóan teljesebb eredményekhez vezetne. Jelen javaslatunkban a klinikai igény kiszolgálására alkalmas elméleti modellek felállításához szükséges kvantitatív adatok kinyeréséhez a digitális dermatológiai képek feldolgozásával kívánunk eljutni. A melanoma detektálásához jelenleg elterjedten használt protokollba számos további klinikai megfigyelés beépíthető a korszerű irodalmi ajánlások alapján. Ide tartozik például az anyajegyek mintázat alapú vizsgálata, az alkotók szabályos térbeli elhelyezkedésének mérése, valamint az időbeli változás több szempont szerint történő követése. A kutatás célja olyan modellek felállítása és tesztelése, amelyek alkalmasak lehetnek a jelenlegi melanoma szűrés protokolljának bővítésére automatikus rendszerekben is. Az ilyen jellegű szűrésekre óriási társadalmi igény mutatkozik, ami előrevetíti a kutatási eredmények piacosíthatóságát is. A szükséges klinikai, matematikai és informatikai hátteret a projektbe bevont tapasztalt kutatók biztosítják.

Summary

The proposed research aims to make the detection of melanoma more efficient which field has a large impact in the society. The foundation of the research group was also motivated by the idea to involve experienced sciences orientated in more theoretical studies into a field which has direct impact for wide public. Our former experiences suggest that clinical and technological research are often missing theoretical support, however its presence could make the results more comprehensive and better founded. In our current proposal, to serve clinical needs we plan to apply image processing approaches to extract quantitative data from dermatologic images based on which theoretical models can be composed. In this way, several state-of-the-art clinical observations may be integrated in the current clinical protocol to improve the detection of melanoma. Such additions include the analysis of moles based on their texture, the measurement of the spatial regularity of the tissue components, and the temporal tracking of the mole changes at different levels. The aim of the research is to set up and test such models that may broaden the range of the current clinical protocol for melanoma detection in automatic screening systems, as well. There is a very strong need from the whole society for efficient melanoma detection and screening which predicts the exploitability of this research in economics. The necessary clinical, mathematical and technological background is provided by the senior researchers involved in the project.

Final report

Results in Hungarian

Alapkutatási eredményeink közül kiemelhetők a rosszindulatú melanóma jelenlétét a pigmentáció textúrázottsága alapján meghatározó vizsgálataink. Különböző képfeldolgozó technikák segítségével kiemeltük és analizáltuk a pigmentáció hálóstruktúráját. Az eredményekből automatikus osztályozóval támogatható a diagnózis. Fúziós technikák segítségével a pigmentáció szegmentációjában is használható algoritmust fejlesztettünk. Több gyorsító eljárást javasoltunk egyedi eljárások és kombinált rendszerek paramétereinek optimális beállításához sztochasztikus keresőkben. Hatékony, a melanóma vizsgálatához is használható technikát adtunk meg genetikai adatok vizualizációjához. A fenti eljárások hátterében általunk kidolgozott matematikai modellek állnak. Nagy hangsúlyt fektettünk a gyakorlati alkalmazhatóságra, eredményeink konkrét alkalmazására. Létrehoztunk egy képi adatbázist, mely lehetővé teszi a fejlesztők és az orvos szakértők számára az adatok központi tárolását, könnyű elérését és megfelelő szűrését. Adatbázisunkat és a hozzá tartozó klinikai annotációkat nyilvánossá tettük. Szintén elérhetővé tettünk egy klinikai felhasználású alkalmazást, amely tetszőleges böngészőből – akár mobil eszközökről is – elérhető. Az alkalmazás segíti a bőrgyógyász szakemberek napi rutinját: támogatja a képi adatbázis elérését, a megfelelő annotálhatóságot és képfeldolgozó eszközöket biztosít a dermatológiai képek minőségének javításához. Eredményeinket nemzetközi szakmai fórumokon publikáltuk.

Results in English

From our fundamental research, we underline our results detecting the presence of melanoma based on the texture of pigmentation. Based upon several image processing techniques, we found and analyzed the lattice structure of the pigmentation. From these results, the diagnosis can be supported by an automatic classifier. Using fusion techniques, we developed an algorithm applicable also in the segmentation of the pigmentation. We proposed several speeding-up procedures making the parameter settings of individual procedures and combined systems optimal in stochastic search processes. We developed an efficient technique for the visualization of genetic data, which can be applied in melanoma research, as well. For the support of the above investigations we developed several mathematical models. We put strong focus also on practical applications. We constructed an image database, which makes it possible to the developers and dermatologists to store data at server side, and to access and filter them easily. Our database and its clinical annotation were made publicly available. Moreover, we released a clinical application, which can be accessed from any – also mobile – web browsers. The application helps the daily routine of dermatologists: it supports the access of the image database with the appropriate annotations, and provides image processing tools for the improvement of the quality of the dermatologic images. Our results have been published at international forums.

Full text

https://www.otka-palyazat.hu/download.php?type=zarobeszamolo&projektid=101680

Decision

Yes

List of publications

B. Antal, A. Hajdu: Improving microaneurysm detection in color fundus images by using context-aware approaches, Elsevier - Computerized Medical Imaging and Graphics 37 (2013), 403–408, 2013

Hajdu L. és R. Tijdeman: Bounds for approximate discrete tomography solutions, SIAM Journal on Discrete Mathematics 27 (2013), 1055–1066, 2013

Bérczes A., A. Dujella és Hajdu L.: Some diophantine properties of the sequence of S-units, J. Number Theory 138 (2014) 48–68, 2013

D. Dombek, Hajdu L. and Pethő A.: Representing algebraic integers as linear combinations of units, Period. Math. Hung. 68 (2014), 135-142, 2013

Baran, S., Pap, G., Sikolya, K.: Testing stability in a spatial unilateral autoregressive model, Comm. Statistics Theory Methods, in press, 2013

I. Lázár, A. Hajdu: Keresztmetszeti intenzitás profilokon alapuló mikroaneurizma detektálás és érhálózat szegmentálás retina képeken, Képfeldolgozók és Alakfelismerők Országos Konferenciája (KÉPAF), 2013

K. J. Batenburg, W. Fortes, Hajdu L. és R. Tijdeman: Bounds on the quality of reconstructed images in binary tomography, Disc. Appl. Math. 161 (2013) 2236–2251, 2013

Emri E, Egervari K, Varvolgyi T, Rozsa D, Miko E, Dezso B, Veres I, Mehes G, Emri G, Remenyik E.: Correlation among metallothionein expression, intratumoural macrophage infiltration and the risk of metastasis in human cutaneous malignant melanoma, J Eur Acad Dermatol Venereol 27(3):e320-e327. (2013), 2013

Boros G, Miko E, Muramatsu H, Weissman D, Emri E, Rózsa D, Nagy G, Juhász A, Juhász I, van der Horst G, Horkay I, Remenyik E, Karikó K, Emri G.:: Transfection of pseudouridine-modified mRNA encoding CPD-photolyase leads to repair of DNA damage in human keratinocytes: A new approach with future therapeutic potential, J Photochem Photobiol B 129:93-99. (2013), 2013

Rakosy Z, Ecsedi S, Toth R, Vizkeleti L, Hernandez-Vargas H, Lazar V, Emri G, Szatmari I, Herceg Z, Adany R, Balazs M.:: Integrative genomics identifies gene signature associated with melanoma ulceration, PLoS One. 2013;8(1):e54958. doi: 10.1371/journal.pone.0054958. Epub 2013 Jan 30. Erratum in: PLoS One. 2013;8(4). doi:10.1371/annotation/27b2c2c3-3b09-4c0c-9e20-8dc022640, 2013

Boros G, Mikó E, Horkay I, Karikó K, Emri G, Remenyik É: Az mRNS-alapú génterápia dermatológiai alkalmazásának lehetőségei: fényvédelem újragondolva, Bőrgy Venerol Szle 89:119-122. (2013), 2013

Balint Antal, Andras Hajdu:: An ensemble-based system for automatic screening of diabetic retinopathy,, Knowledge-Based Systems (Elsevier) 64 (2014), 20–27, 2014

Zsolt Torok, Tunde Peto, Eva Csosz, Edit Tukacs, Agnes Molnar, András Berta, Jozsef Tozser, Andras Hajdu, Valéria Nagy, Balint Domokos, Adrienne Csutak: Combined methods for diabetic retinopathy screening, using retina photographs and tear fluid proteomics biomarkers, Journal of Diabetes Research (2014), Paper 623619, 8 pages, 2014

B. Harangi, A. Hajdu: Automatic Exudate Detection by Fusing Multiple Active Contours and Regionwise Classification, Elsevier - Computerized Medical Imaging and Graphics 54 (2014), 156-171, 2014

J. Toth, L. Szakacs, A. Hajdu: Finding the optimal parameter setting of an ensemble-based system for object detection purposes, IEEE ICIP 2014, 3532 - 3536, 2014

S. Akiyama, L. Aszalós, L. Hajdu, A. Pethő: Correlation clustering of graphs and integers, Infocommunication J. 6 (2014), 3-12, 2014

A. Bérczes, L. Hajdu, N. Hirata-Kohno, T. Kovács, A. Pethő: A key exchange protocol based on Diophantine equations and S-integers, JSIAM Letters 6 (2014), 85-88, 2014

I. Lazar, A. Hajdu: Segmentation of Vessels in Retinal Images Based on Directional Height Statistics, 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC2012), San Diego, USA, 2012, 1458-1461, 2012

B. Antal, I. Lazar, A. Hajdu: An adaptive weighting approach for ensemble-based detection of microaneurysms in color fundus images, 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC2012), San Diego, USA, 2012, pp. 5955-5958, 2012

B. Harangi, I. Lazar, A. Hajdu: Automatic Exudate Detection Using Active Contour Model and Regionwise Classification, 34th Annual International Conference of the Engineering in Medicine and Biology Society (EMBC 2012), San-Diego, California, USA, 2012, pp. 5951-5954, 2012

B. Harangi, B. Antal, A. Hajdu: Automatic Exudate Detection with Improved Naïve-Bayes Classifier, 25th IEEE International Symposium on Computer-Based Medical System (CBMS 2012), Rome, Italy, 2012, pp. 1-4, 2012

B. Harangi, B. Nagy, A. Hajdu: Improving the detection of excessive activation of ciliaris muscle by clustering thermal images, 11th Quantitative InfraRed Thermography (QIRT 2012), Naples, Italy, 2012, pp. 1-4, 2012

B. Harangi, A. Hajdu: Improving the accuracy of optic disc detection by finding maximal weighted clique of multiple candidates of individual detectors, 9th IEEE International Symposium on Biomedical Imaging (ISBI 2012), Barcelona, Spain, 2012, pp. 602-605, 2012

R. J. Qureshi, L. Kovacs, B. Harangi, B. Nagy, T. Peto, A. Hajdu: Combining algorithms for automatic detection of optic disc and macula in fundus images, ELSEVIER Computer Vision and Image Understanding”, Computer Vision and Image Understanding, vol. 116, no. 1, pp 138-145, 2012

A. Hajdu, J. Tóth, Z. Pistár, B. Domokos, Zs. Török: An ensemble-based collaborative framework to support customized user needs, 3rd IEEE International Conference on Cognitive Infocommunications (CogInfoCom 2012), Kosice, Slovakia, 2012, 285-290, 2012

Hajdu L. és Szikszai M.: On the GCD-s of k consecutive terms of Lucas sequences, J. Number Theory 132 (2012) 3056-3069, 2012

Hajdu L. és R. Tijdeman: Representing integers as linear combinations of power products, Arch. Math. 98 (2012), 527-533, 2012

Hajdu A., Hajdu L. és R. Tijdeman: Approximation of Euclidean distances by chamfer distances, Acta Cybernetica 20 (2012), 399-417, 2012

Baran, S., Sikolya, K.: Parameter estimation in linear regression driven by a Gaussian sheet, Acta Sci. Math. (Szeged) 78 (2012), 689-713, 2012

Baran, S., Sikolya, K.: Parameter estimation in linear regression driven by a Wiener sheet, Ann. Math. Inform. 39 (2012), 3-15, 2012

Baran, S., Pap, G.: Parameter estimation in a spatial unit root autoregressive model, J. Multivariate Anal. 107 (2012), 282-305, 2012

Emri G: Immunterápia melanoma malignumban, Orvostovábbképző Szemle Különszám (2012. október) pp 12-15, 2012

Vízkeleti L, Ecsedi S, Rákosy Z, Orosz A, Lázár V, Emri G, Koroknai V, Kiss T, Ádány R, Balázs M.: The role of CCND1 alterations during the progression of cutaneous malignant melanoma, Tumour Biol. 2012 Dec;33(6):2189-99, 2012

Lázár V, Ecsedi S, Vízkeleti L, Rákosy Z, Boross G, Szappanos B, Bégány A, Emri G, Adány R, Balázs M.: Marked genetic differences between BRAF and NRAS mutated primary melanomas as revealed by array comparative genomic hybridization, Melanoma Res. 2012 Jun;22(3):202-14, 2012

Géhl Z, Bai P, Bodnár E, Emri G, Remenyik É, Németh J, Gergely P, Virág L, Szabó É.: Poly(ADP-ribose) in the skin and in melanomas, Histol Histopathol. 2012 May;27(5):651-9, 2012

Vizkeleti L, Ecsedi S, Rakosy Z, Begany A, Emri G, Toth R, Orosz A, Szollosi AG, Mehes G, Adany R, Balazs M.: Prognostic relevance of the expressions of CAV1 and TES genes on 7q31 in melanoma, Front Biosci (Elite Ed). 2012 Jan 1;4:1802-12, 2012

Tomán H., Kovács L., Jónás Á., Hajdu L. és Hajdu A.: Generalized weighted majority voting with an application to algorithms having spatial output, 7th Int. Conf. on Hybrid Artificial Intelli-gence Systems (HAIS 2012), Lecture Notes in Computer Science, vol. 7209, pp. 56-67, 2012

Hajdu L. és N. Saradha: Disproof of a conjecture of Jacobsthal, Math. Comp. 81 (2012), 2461-2471, 2012

Hajdu L., N. Saradha és R. Tijdeman: On a conjecture of Pomerance, Acta Arith. 155 (2012), 175-184, 2012

Hajdu L., Kovács T., Pethő A. és M. Pohst: On an optimization problem concerning lattices, Experimental Math. 22 (2013), 443-455., 2013

D. Dombek, Hajdu L. and Pethő A.: Representing algebraic integers as linear combinations of units, Period. Math. Hung. (közlésre elfogadva), 2013

Hajdu L. és V. Ziegler: Distinct unit generated totally complex quartic fields, Math. Comp. (közlésre elfogadva), 2013

K. J. Batenburg, W. Fortes, Hajdu L. és R. Tijdeman: Bounds on the quality of reconstructed images in binary tomography, Disc. Appl. Math. (közlésre elfogadva), 2013

B. van Dalen, Hajdu L. és R. Tijdeman: Bounds for discrete tomography solutions, Indag. Math. 24 (2013), 391-402., 2013

Baran, S., Sikolya, K., Veress, L.: Estimating the risk of a Down’s syndrome term pregnancy using age and serum markers: Comparison of various methods, Comm. Statist. Simulation Comput. 42 (2013), no. 7, 1654-1672., 2013

I. Lazar, A. Hajdu: Retinal Microaneurysm Detection Through Local Rotating Cross-section Profile Analysis, IEEE Transactions on Medical Imaging, 32(2) (February 2013), 400-407,, 2013

B. Harangi, A. Hajdu: Aktív kontúr használatával és régió alapú osztályozással pontosított exudátum detektáló algoritmus, Képfeldolgozók es Alakfelismerők Országos Konferenciája (KEPAF 2013), 2013

A. Hajdu, J. Szakacs, J. Toth, A. Ayoub: Automatikus pigmenthalozat-detektalas dermatoszkopos kepeken, Automatikus pigmenthalozat-detektalas dermatoszkopos kepeken, Kepfeldolgozok es Alakfelismerok Orszagos Konferenciaja (KEPAF 2013), Bakonybel, Hungary, to appear, 2013

Hajdu L. és Szikszai M.: On common factors within a series of consecutive terms of an elliptic divisibility sequence, Publ. Math. Debrecen (közlésre elfogadva)., 2013

Bérczes A., A. Dujella és Hajdu L.: Some diophantine properties of the sequence of S-units, J. Number Theory (közlésre elfogadva), 2013

Hajdu L. és R. Tijdeman: Bounds for approximate discrete tomography solutions, SIAM Journal on Discrete Mathematics (közlésre elfogadva), 2013

Kovács L., Tomán H., Jónás Á., Hajdu L. és Hajdu A.: Generalizing the majority voting scheme to spatially constrained voting, közlésre benyújtva, 2013

Baran, S., Sikolya, K., Stehlík, M.: On the optimal designs for prediction of Ornstein-Uhlenbeck sheets, Statist. Probab. Lett., 83 (2013), no. 6, 1580-1587., 2013

Baran, S., Stehlík, M.: Optimal designs for parameters of shifted Ornstein-Uhlenbeck sheets measured on monotonic sets, Appl. Stoch. Model. Bus., benyújtott (arXiv:1312.0099)., 2013

Baran, S., Pap, G., Sikolya, K.: Testing stability in a spatial unilateral autoregressive model, Comm. Statistics Theory Methods, elfogadva, 2013

Baran, S., Horányi, A., Nemoda, D.: Statistical post-processing of probabilistic wind speed forecasting in Hungary., Meteorol. Z. 22 (2013), no. 3, 273-282., 2013

B. Harangi, A. Hajdu: Automatic Exudate Detection by Fusing Multiple Active Contours and Regionwise Classification, Elsevier - Computerized Medical Imaging and Graphics, submitted, 2013

Gy. Kovacs and A. Hajdu: Translation Invariance in the Polynomial Kernel Space and Its Applications in kNN Classification, Neural Processing Letters (Springer) (September 2012), 1-27, 2012

Edit Tukacs, Agnes Korotij, Zsuzsanna Maros-Szabo, Agnes Marta Molnar, Andras Hajdu, Zsolt Torok: Model requirements for Biobank Software Systems, Bioinformation 8(6) (2012), 290-292, 2012

Balint Antal, Andras Hajdu: An Ensemble-based System for Microaneurysm Detection and Diabetic Retinopathy Grading, IEEE Trans. on Biomedical Engineering 59(6) (2012), 1720-1726, 2012

Balint Antal, Andras Hajdu, Zsuzsa Szabo-Maros, Zsolt Torok, Adrienne Csutak, Tunde Peto: A Two-phase Decision Support Framework for the Automatic Screening of Digital Fundus Images, Journal of Computational Science (Elsevier) 3(5) (2012), 262-268, 2012

Ahmed Ayoub, Andras Hajdu, Arpad Nagy: Automatic Detection of Pigmented Network in Melanoma Dermoscopic Images, The International Journal of Computer Science and Communication Security (IJCSCS) 2 (January 2012), 58-63, 2012

Bálint Antal, András Hajdu: Improving microaneurysm detection using an optimally selected subset of candidate extractors and preprocessing methods, Pattern Recognition 45 (2012), 255-261, 2012

B. Harangi, A. Hajdu: Improving automatic exudate detection based on the fusion of the results of multiple active contours, 10th IEEE International Symposium on Biomedical Imaging (ISBI 2013), San Francisco, USA, 2013, 45-48, 2013

B. Antal, A. Hajdu: Improving microaneurysm detection in color fundus images by using context-aware approaches, Elsevier - Computerized Medical Imaging and Graphics, to appear., 2013

Zsolt Páles, Ioan-Radu Petre: Iterative fixed point theorems in E-metric spaces, Acta Mathematica Hungarica, volume 140, 2013, 134-144., 2013

Andrej Dujella, Kálmán Győry and Ákos Pintér: On power values of pyramidal numbers, I, Acta Arithmetica, 155 (2012), 217-226, 2012

András Bazsó, Dijana Kreso, Florian Luca and Ákos Pintér: On equal values of power sums of arithmetic progressions, Glasnik Math., 47 (2012), 253-263, 2012

Yuri Bilu, Clemens Fuchs, Florian Luca and Ákos Pintér: Combinatorial diophantine equations and a refinement of a theorem on separated variables equations, Publ. Math. Debrecen, 82:(1) pp. 219-254 (2013), 2013

Ákos Pintér and Hari Srivastava: Addition theorems for the Appell polynomials and the associated classes of polynomial expansions, Aequationes Mathematicae, 85:(3) pp. 483-495 (2013), 2013

Daeyeoul Kim, Yoon Kyung Park and Ákos Pintér: A diophantine problem concerning polygonal numbers, Bulletin of Australian Math. Society 88:(2) pp. 345-350. (2013), 2013

Ákos Pintér and Szabolcs Tengely: The Korteweg-de Vries equation and a diophantine problem related to Bernoulli polynomials, Advances in Difference Equations 2013: Paper 2013:245, 2013

Hajdu L., Pintér Á., Tengely Sz. and Varga N.,: Equal values of figurate numbers,, J. Number Theory (közlésre elfogadva)., 2014

S. Brunetti, P. Dulio, Hajdu L., C. Peri,: Discrete Tomography towards Denoising Ghosts, (közlésre benyújtva)., 2014

Zsolt Torok, Tunde Peto, Eva Csosz, Edit Tukacs, Agnes Marta Molnar, Zsuzsanna Maros-Szabo1, Andras Berta, Jozsef Tozser, Andras Hajdu, Valeria Nagy, Balint Domokos, Adrienne Csutak:: Tear fluid proteomics multimarkers for diabetic retinopathy screening,, BMC Opthalmology 13(40) (August 2013), 8 pages,, 2013

Andras Hajdu, Lajos Hajdu, Agnes Jonas, Laszlo Kovacs, Henrietta Toman:: Generalizing the majority voting scheme to spatially constrained voting,, IEEE Trans. on Image Processing 22(11) (November 2013), 4182-4194,, 2013

Balint Antal, Andras Hajdu:: An ensemble-based system for automatic screening of diabetic retinopathy,, Knowledge-Based Systems (Elsevier) (2013), (közlésre elfogadva)., 2014

J. Toth, I. Papp, R. Tornai, I. Labancz, E. H. Pocsai, A. Hajdu:: Cognitive visualization for the design of complex systems,, 4th IEEE International Conference on Cognitive Infocommunications (CogInfoCom 2013), Budapest, Hungary, 2013, 363-368., 2013

Cs. Lamfalusi, D. Girus, K. Kruppa, J. Toth, E. H. Pocsai, R. Kunkli, A. Hajdu, B. L. Balint:: Extending the visualization capabilities of a genome browser,, 4th IEEE International Conference on Cognitive Infocommunications (CogInfoCom 2013), Budapest, Hungary, 2013, 419-422., 2013

Cs. Lamfalusi, D. Girus, K. Kruppa, J. Toth, E. H. Pocsai, R. Kunkli, A. Hajdu, B. L. Balint:: Adding a scalable visualization technique to the UCSC genome browser,, 4th IEEE International Conference on Cognitive Infocommunications (CogInfoCom 2013), Budapest, Hungary, 2013, 943 (demo paper)., 2013

A. Hajdu, L. Hajdu, L. Kovacs, H. Toman:: Diversity Measures for Majority Voting in the Spatial Domain,, 8th International Conference on Hybrid Artificial Intelligence Systems (HAIS 2013), Lecture Notes in Artificial Intelligence 8073, 2013, 314-323., 2013

B. Antal, A. Hajdu:: Evaluation of Preprocessing Methods for Microaneurysm Detection,, IEEE-EURASIP 8th Int'l Symposium on Image and Signal Processing and Analysis, Trieste, Italy, 2013, 716-719., 2013

B. Nagy, B. Antal, A. Hajdu:: Database Clustering To Improve Exudate Detection In Color Fundus Images,, IEEE-EURASIP 8th Int'l Symposium on Image and Signal Processing and Analysis, Trieste, Italy, 2013, 720-724., 2013

B. Antal, B. Remenyik, A. Hajdu:: An Unsupervised Ensemble-based Markov Random Field Approach to Microscope Cell Image Segmentation,, 10th International Conference on Signal Processing and Multimedia Applications (SIGMAP 2013), Reykjavík, Iceland, 2013, 94-99., 2013

Bo He, István Pink, Ákos Pintér, Alain Togbé,: On the diophantine inequality |X2-cXY2+Y4|<=c+2, GLASNIK MATEMATICKI 48:(2) pp. 291-299. (2013), 2013

Baran, S.,: Probabilistic wind speed forecasting using Bayesian model averaging with truncated normal components., Comput. Stat. Data. Anal., benyújtva (arXiv:1305:1184)., 2014

Baran, S., Horányi, A., Nemoda, D.,: Probabilistic temperature forecasting with statistical calibration in Hungary., Meteorol. Atmos. Phys., benyújtva (arXiv:1303.2133)., 2014

J. Toth, L. Szakacs, A. Hajdu: Optimizing the parameter setting of an ensemble-based system for object detection purposes, IEEE ICIP, közlésre benyújtva, 2014

Hajdu L, Pink I: On the Diophantine equation 1+2^a+x^b=y^n, J NUMBER THEORY 143: 1-13, 2014

Hajdu L. és V. Ziegler: Distinct unit generated totally complex quartic fields, Math. Comp. 83 (2014) 1495-1512, 2014

Hajdu L. és Szikszai M.: On common factors within a series of consecutive terms of an elliptic divisibility sequence, Publ. Math. Debrecen 2014 (84) 291–301, 2014

Gyory K, Hajdu L, Tijdeman R: Representation of finite graphs as difference graphs of S-units, I, J COMB THEORY A 127: (1) 314-335, 2014

Hajdu L., Pintér Á., Tengely Sz. and Varga N.,: Equal values of figurate numbers,, J. Number Theory 137 (2014), 130–141, 2014

Baran, S.,: Probabilistic wind speed forecasting using Bayesian model averaging with truncated normal components., Comput. Stat. Data. Anal. 75 (2014), 227–238, 2014

Baran, S., Horányi, A., Nemoda, D.,: Probabilistic temperature forecasting with statistical calibration in Hungary., Meteorol. Atmos. Phys. 124 (2014), 129-142, 2014

Baran, S., Horányi, A., Nemoda, D.: Comparison of the BMA and EMOS statistical methods in calibrating temperature and wind speed forecast ensembles, Időjárás 118 (2014), no. 3, 217-241, 2014

K. Győry, T. Kovács, Gy. Péter, Á. Pintér: Equal values of standard counting polynomials, PUBLICATIONES MATHEMATICAE-DEBRECEN 84:(1-2) pp. 259-277. (2014), 2014

Gál, Z., Almási, B., Dabóczi, T., Vida, R., Oniga, S., Baran, S., Farkas, I.: Internet of things: application areas and research results of the FIRST project, Infocomm. J. 6 (2014), no. 3, 37-44, 2014

Ecsedi S, Hernandez-Vargas H, Lima SC, Vízkeleti L, Tóth R, Lázár V, Koroknai V, Kiss T, Emri G, Herceg Z, Ádány R, Balázs M: DNA methylation characteristics of primary melanomas with distinct biological behaviour, PLoS One 9(5):e96612. (2014), 2014

Pokol E, Deim N, Veres I, Galuska L, Erdei I, Dezső B, Péter Z, Remenyik É, Emri G, Juhász I: Sentinel nyirokcsomó-biopszia melanoma malignumban: 10 év tapasztalatának eredményei a DEOEC Bőrgyógyászati Klinikáján, Bőrgy Venerol Szle 90(3):100-105. (2014), 2014

Gellén E, Emri G, Szegedi A, Horkay I, Remenyik É: Az UV-sugárzás biológiai hatásai és kapcsolata a gyermekkorral, Gyermekorvos Továbbképzés 13(1):24-28. (2014), 2014

Emri G: Bőrdaganatok kezelésének új lehetőségei, Orvostovábbképző Szle 21(7-8):36-41. (2014), 2014

Mohammad Reza Azodinia, Andras Hajdu: A method for image retrieval using combination of color and frequency layers, International Journal of Computer Applications 118(3) (May 2015), 10-13, 2015

Balazs Harangi, Andras Hajdu: Detection of the optic disc in fundus images using information fusion, Computers in Biology and Medicine (Elsevier) (2015), to appear, 2015

S. Brunetti, P. Dulio, Hajdu L., C. Peri,: Discrete Tomography towards Denoising Ghosts, Journal of Mathematical Imaging and Vision (kozlésre elfogadva), 2015

J. Toth, I. Lazar, L. Barta, B. Harangi, A. Hajdu: An application and an online platform for analyzing and sharing dermatological data, 6th IEEE International Conference on Cognitive Infocommunications (CogInfoCom 2015), Gyor, Hungary, 2015, accepted, 2015

R. Karimi, A. Hajdu: A novel pipeline for real-time identification of species from high-throughput sequencing reads in metagenomics and clinical diagnostic assays, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC2015), Milano, Italy, 2015, 4 pages, 2015

J. Toth, H. Toman, A. Hajdu: Improving the performance of an ensemble-based exudate detection system using stochastic parameter optimization, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC2015), Milano, Italy, 2015, 4 pages., 2015

Mohammad Reza Azodinia, Andras Hajdu: A recommender system that deals with items having an image as well as quantitative features, IEEE 12th International Symposium on Intelligent Signal Processing (WISP2015), 15-17 May 2015, Siena, Italy, 6 pages., 2015

Renato Besenczi, Kristof Szitha, Andras Hajdu: A framework for distributed processing on an offline cell phone network, 5th IEEE International Conference on Cognitive Infocommunications (CogInfoCom 2014), Vietri sul Mare, Italy, 2014, 257-262., 2015

Janos Toth, Laszló Kovacs, Balazs Harangi, Csaba Kiss, Andras Mohacsi, Zoltan Orosz, Andras Hajdu: An Online Benchmark System for Image Processing Algorithms, 5th IEEE International Conference on Cognitive Infocommunications (CogInfoCom 2014), Vietri sul Mare, Italy, 2014, 377-382., 2015

B. Harangi, A. Hajdu: Detection of exudates in fundus images using a Markovian segmentation model, 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC2014), Chicago, USA, 2014, 130-133., 2015

R. Karimi, L. Bellatreche, P. Girard, A. Boukorca, A. Hajdu: Bitmap indexes and NoSQL for identifying species with DNA signatures through metagenomics samples, 5th International Conference on Information Technology in Bio- and Medical Informatics (ITBAM 2014), Munich, Germany, Lecture Notes in Computer Science 8649, 2014, 1-14., 2015

Cs. Bertók, L. Hajdu: On a Hasse-type principle for exponential diophantine equations and its applications, Math. Comput. (accepted for publication), 2015

A. Custic, L. Hajdu, D. Kreso, R. Tijdeman: On conjectures and problems of Ruzsa, concerning difference graphs of S-units, Acta Math. Hungar. (közlésre elfogadva), 2015

L. Hajdu: On a conjecture of Schaffer concerning the equation 1^k+...+x^k=y^n, J. Number Theory 155 =2015), 129-138, 2015

L. Hajdu, M. Szikaszai: Common factors in series of consecutive terms of associated Lucas and Lehmer sequences, Fibonacci Quart. (közlésre elfogadva), 2015

Baran, S., Möller, A.: Joint probabilistic forecasting of wind speed and temperature using Bayesian model averaging, Environmetrics 26 (2015), no. 2, 120-132, 2015

Gellén E, Sántha O, Janka E, Juhász I, Péter Z, Erdei I, Lukács R, Fedinecz N, Galuska L, Remenyik É, Emri G: Diagnostic accuracy of 18F-FDG-PET/CT in early and late stages of high-risk cutaneous malignant melanoma, J Eur Acad Dermatol Venereol 2015 Mar 9. doi: 10.1111/jdv.13084. [Epub ahead of print] (2015), 2015

Baran, S., Stehlík, M.: Optimal designs for parameters of shifted Ornstein-Uhlenbeck sheets measured on monotonic sets, Statist. Probab. Lett. 99 (2015), 114-124., 2015

Almádi Tamás, Sawhney Irina, Tóth Anett, Szilágyi Eszter, Remenyik Éva, Emri Gabriella: Új terápiás lehetőségek metasztatikus melanoma malignumban. Esetriport, Bőrgyógyászati és Venerológiai szemle (revízió alatt), 2015

M. Bessenyei, Zs. Páles: A contraction principle in generalized metric spaces, Journal of Nonlinear and Convex Analysis (közlésre elfogadva), 2015

Bo He, Á. Pintér, A. Togbé: On simultaneous Pell equation and related Thue equations, PROCEEDINGS OF THE AMERICAN MATHEMATICAL SOCIETY, megjelenés alatt, 2015

Bo He, Á. Pintér, A. Togbé, N. Varga: A generalization of a problem of Mordell, GLASNIK MATEMATICKI 50:(1) pp. 35-41. (2015), 2015

M. Bennett, Á. Pintér: Intersections of recurrence sequences, PROCEEDINGS OF THE AMERICAN MATHEMATICAL SOCIETY 143: pp. 2347-2353. (2015), 2015

Á. Pintér, Cs. Rakaczki: On the decomposability of linear combinations of Bernoulli polynomials, MONATSHEFTE FUR MATHEMATIK, megjelenés alatt, 2015

Renato Besenczi, Kristof Szitha, Andras Hajdu: Distributed eye lesion detection on an offline cell phone network, 5th IEEE International Conference on Cognitive Infocommunications (CogInfoCom 2014), Vietri sul Mare, Italy, 2014, abstract, 467., 2015

Janos Toth, Laszló Kovacs, Balazs Harangi, Csaba Kiss, Andras Mohacsi, Zoltan Orosz, Andras Hajdu: An Online System for Algorithm Benchmarking, 5th IEEE International Conference on Cognitive Infocommunications (CogInfoCom 2014), Vietri sul Mare, Italy, 2014, abstract, 383., 2015

Baran, S., Lerch, S.: Log-normal distribution based EMOS models for probabilistic wind speed forecasting, Q. J. R. Meteorol. Soc., doi:10.1002/qj.2521, 2015

Boros Gábor, Mikó Edit, Muramatsu Hiromi, Weissman Drew, van der Horst Gijsbertus TJ, Szegedi Andrea, Horkay Irén, Emri Gabriella, Karikó Katalin, Remenyik Éva: Identification of cyclobutane pyrimidine dimer-responsive genes using UVB-irradiated human keratinocytes transfected with in vitro-synthesized photolyase mRNA, PLoS One 2015 Jun 29;10(6):e0131141. doi: 10.1371/journal.pone.0131141, 2015

Emri E, Mikó E, Bai P, Boros G, Nagy G, Rózsa D, Juhász T, Hegedűs Cs, Horkay I, Remenyik É, Emri G: Effects of non-toxic zinc exposure on human epidermal keratinocytes, Metallomics 7(3):499-507. (2015), 2015

Kiss T, Ecsedi S, Vízkeleti L, Koroknai V, Emri G, Kovács N, Ádány R, Balázs M: The role of osteopontin expression in melanoma progression, Tumour Biol 2015 May 7. [Epub ahead of print] (2015), 2015

Baran, S., Sikolya, K., Stehlík, M.: Optimal designs for the methane flux in troposphere, Chemometr. Intell. Lab., doi:10.1016/j.chemolab.2015.06.002, 2015

Events of the project

2014-03-26 12:23:40

Résztvevők változása

Back »