Bisphosphonate-related osteonecrosis of the jaw: preventive and therapeutic alternatives  Page description

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Details of project

 
Identifier
109388
Type K
Principal investigator Piffkó, József
Title in Hungarian Biszfoszfonát-indukálta állcsont necrosis: megelőzési és terápiás alternatívák
Title in English Bisphosphonate-related osteonecrosis of the jaw: preventive and therapeutic alternatives
Keywords in Hungarian biszfoszfonát, osteonecrosis, osteoporosis, VEGF, angiogenesis,
Keywords in English bisphosphonate, osteonecrosis of the jaw, osteoporosis, VEGF, angiogenesis,
Discipline
Biological basis of diseases related to the above (Council of Medical and Biological Sciences)40 %
Clinical pharmacology, gene therapy, cell therapy, regenerative medicine (Council of Medical and Biological Sciences)30 %
Medical engineering and technology (Council of Medical and Biological Sciences)30 %
Panel Physiology, Pathophysiology, Pharmacology and Endocrinology
Department or equivalent Department of Oral And Maxillofacial Surgery (University of Szeged)
Participants Garab, Dénes
Hartmann, Petra
Janovszky, Ágnes
Lázár, Péter György
Sipka, Balázs
Szabó, Andrea
Varga, Renáta
Zsoldiné dr. Urbán, Edit
Starting date 2014-01-01
Closing date 2017-12-31
Funding (in million HUF) 19.992
FTE (full time equivalent) 10.48
state running project





 

Final report

 
Results in Hungarian
I. A novel method for the in vivo visualization and investigation of the mandibular periosteum II. Microcirculatory aspects of bisphosphonate-related osteonecrosis of the jaw III. Effect of ischemic reperfusion on the periosteal microcirculation in osteoporotic rats treated with bisphosphonate IV. Preventive effect of light (low-level laser and LED) and shock wave on the development of medication-related osteonecrosis of the jaw (MRONJ) V. Controlled-release of angiogenic factors to prevent the development of medication-related osteonecrosis of the jaw (MRONJ) VI. Limited efficacy of ischemic preconditioning in ovariectomized rats. Potential preconditioning-dependent and independent effects of estrogen supplementation.
Results in English
I. Módszer kidolgozása a mandibularis periosteum in vivo vizsgálatára patkányon II. Biszfoszfonát-indukálta állcsont necrosis mikrokeringési aspektusainak vizsgálata III. Az osteoporosis és az alsó végtagi ischaemia-reperfúzió mikrokeringési hatásainak vizsgálata krónikus biszfoszfonát-kezelést követően IV. A fény (alacsony energiájú lézer és LED) és lökéshullám terápia preventív hatásának vizsgálata gyógyszer-indukálta állcsont necrosis állatkísérletes modelljében V. A kontrollált angiogén faktorok felszabadulásának szerepe a gyógyszer-indukálta állcsont necrosis megelőzésében VI. Az ischemiás prekondícionálás limitált hatása osteoporosisban
Full text https://www.otka-palyazat.hu/download.php?type=zarobeszamolo&projektid=109388
Decision
Yes





 

List of publications

 
Raskó Z, Nagy L, Radnai M, Piffkó J, Baráth Z.: Assessing the Accuracy of Cone-Beam Computerized Tomography in Measuring Thinning Oral and Buccal Bone., J Oral Implantol. 2016 Jun;42(3):311-4., 2016
Szabó A, Janovszky Á, Pócs L, Boros M.: The periosteal microcirculation in health and disease: An update on clinical significance., Microvasc Res. 2016 Nov 23;110:5-13., 2016
Boa K, Barrak I, Varga E Jr, Joob-Fancsaly A, Varga E, Piffko J.: Intraosseous generation of heat during guided surgical drilling: an ex vivo study of the effect of the temperature of the irrigating fluid., Br J Oral Maxillofac Surg. 2016 Oct;54(8):904-908., 2016
Barrak IÁ, Varga E, Piffko J.: Navigation in implantology: Accuracy assessment regarding the literature., Fogorv Sz. 2016 Jun;109(2):61-8., 2016
Lóderer Z, Janovszky Á, Lázár P, Piffkó J.: Surgical Management of Progressive Hemifacial Atrophy With De-Epithelialized Profunda Artery Perforator Flap: A Case Report., J Oral Maxillofac Surg. 2016 Oct 29., 2016
Vass G, Mohos G, Bere Z, Ivan L, Varga J, Piffko J, Rovo L.: Secondary correction of nasal deformities in cleft lip and palate patients: surgical technique and outcome evaluation., Head Face Med. 2016 Dec 1;12(1):34., 2016
Lóderer Z, Piffkó J, Somlai K, Bognár G, Sándor G.: Cooperation between the plastic surgery and the head & neck surgery departments in the treatment of unusual cases, Veszprém, Hungary, 2010-2015., Magy Seb. 2016 Dec;69(4):178-185., 2016
Pócs L, Janovszky Á, Garab D, Terhes G, Ocsovszki I, Kaszaki J, Boros M, Piffkó J, Szabó A.: Estrogen-dependent efficacy of limb ischemic preconditioning in female rats., J Orthop Res., 2018
Szabó A, Janovszky Á, Pócs L, Boros M.: The periosteal microcirculation in health and disease: An update on clinical significance., Microvasc Res., 2017
Janovszky A, Szabo A, Varga R, Garab D, Boros M, Mester C, Beretka N, Zombori T, Wiesmann HP, Bernhardt R, Ocsovszki I, Balazs P, Piffko J: Periosteal microcirculatory reactions in a zoledronate-induced osteonecrosis model of the jaw in rats., CLIN ORAL INVEST 19: (6) 1279-1288, 2015
Rasko Z, Nagy L, Radnai M, Piffko J, Barath Z: Assessing the Accuracy of Cone-beam Computed Tomography in Measuring Thinning Oral and Buccal Bon., J ORAL IMPLANTOL &: &, 2015
Seres L, Kocsis A, Varga E, Rasko Z, Virag V, Bago B, Varga E, Piffko J: Virtuális modell-műtét és az okklúziós lemez háromdimenziós nyomtatása súlyos mandibula aszimmetria esetében, FOGORVOSI SZEMLE 108: (2) 45-52, 2015
Janovszky A, Vereb T, Szabó A, Piffkó J.: Current approaches for early detection and treatment of medication-related osteonecrosis of jaw, Orv Hetil. 155(49):1960-6., 2014
Janovszky A, Szabó A, Varga R, Garab D, Boros M, Mester C, Beretka N, Zombori T, Wiesmann HP, Bernhardt R, Ocsovszki I, Balázs P, Piffkó J.: Periosteal microcirculatory reactions in a zoledronate-induced osteonecrosis model of the jaw in rats., Clin Oral Investig., 2014
Varga R, Janovszky Á, Szabó A, Garab D, Bodnár D, Boros M, Neunzehn J, Wiesmann HP, Piffkó J.: A novel method for in vivo visualization of the microcirculation of the mandibular periosteum in rats., Microcirculation. 21(6):524-31., 2014
Janovszky A: Microcirculatory aspects of bisphosphonate-related osteonecrosis of the jaw, Szegedi Tudományegyetem, 2014
Seres L, Varga E Jr, Kocsis A, Rasko Z, Bago B, Varga E, Piffko J: Correction of a severe facial asymmetry with computerized planning and with the use of a rapid prototyped surgical template: a case report/technique article., HEAD FACE MED 10: (1) 27, 2014





 

Events of the project

 
2016-06-29 15:39:12
Résztvevők változása




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