Comprehensive study of the coupling between substrate transport and ATP hydrolysis in P-glycoprotein and ABCG2  Page description

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Details of project

 
Identifier
124815
Type K
Principal investigator Goda, Katalin
Title in Hungarian A szubsztrát transzport és ATP hidrolízis kapcsolatának átfogó vizsgálata a P-glikoprotein és ABCG2 transzporterekben
Title in English Comprehensive study of the coupling between substrate transport and ATP hydrolysis in P-glycoprotein and ABCG2
Keywords in Hungarian ABCB1, ABCG2, katalitikus ciklus, konformáció érzékeny antitest, konformáció változás, hely-specifikus mutagenezis
Keywords in English ABCB1, ABCG2, catalytic cycle, conformation sensitive antibody, conformation changes, site-directed mutagenesis
Discipline
Biophysics (e.g. transport mechanisms, bioenergetics, fluorescence) (Council of Medical and Biological Sciences)40 %
Ortelius classification: Biophysics
General biochemistry and metabolism (Council of Medical and Biological Sciences)30 %
Ortelius classification: Enzimology
Molecular biology (Council of Medical and Biological Sciences)30 %
Ortelius classification: Molecular biology
Panel Molecular and Structural Biology and Biochemistry
Department or equivalent Department of Biophysics and Cell Biology (University of Debrecen)
Participants Gyöngy, Zsuzsanna
Kalló, Gergő
Szabó, Gábor
Szakács, Gergely
Tarapcsák, Szabolcs
Starting date 2017-09-01
Closing date 2021-08-31
Funding (in million HUF) 47.997
FTE (full time equivalent) 8.21
state running project




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