Mechanistic insight into the action of thymidylate biosynthesis targeting chemotherapeutic drugs using next generation sequencing technologies

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Identifier

137867

Type

Principal investigator

Békési, Angéla

Title in Hungarian

Timidilát bioszintézist célzó rákterápiás szerek hatásmechanizmusának vizsgálata újgenerációs szekvenálási technikák bevonásával

Title in English

Mechanistic insight into the action of thymidylate biosynthesis targeting chemotherapeutic drugs using next generation sequencing technologies

Keywords in Hungarian

uracil, U-DNA-Seq, RNA-seq, raltitrexed, 5fluoro-dezoxiribo-uridin, HCT116, uracil-DNS glikoziláz, hibáspár javítás

Keywords in English

uracil, U-DNA-Seq, RNA-seq, raltitrexed, 5fluoro-deoxyuridine, HCT116, uracil-DNA glycosylase, mismatch repair

Discipline

Genomics, comparative genomics, functional genomics (Council of Medical and Biological Sciences)	40 %
Systems biology (Council of Medical and Biological Sciences)	30 %
DNA synthesis, modification, repair, recombination and degradation (Council of Medical and Biological Sciences)	30 %

Panel

Genetics, Genomics, Bioinformatics and Systems Biology

Department or equivalent

Department of Applied Biotechnology and Food Science (Budapest University of Technology and Economics)

Participants

Grolmusz, Vince
Holub, Eszter
Nagy, Nikolett
Pálinkás, Hajnalka Laura
Papp, Gábor
Vértessy G., Beáta

Starting date

2021-10-01

Closing date

2025-09-30

Funding (in million HUF)

39.983