A multisensory loop of the basal ganglia including the superior colliculus and the posterior thalamus in the feline and primate brain. Electrophysiological and morphological investigations.  Page description

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Details of project

 
Identifier
83810
Type K
Principal investigator Benedek, György
Title in Hungarian A bazális ganglionok colliculus superiort és a posterior thalamust tartalmazó pályája. Elektrofiziológiai és anatómiai vizsgálatok
Title in English A multisensory loop of the basal ganglia including the superior colliculus and the posterior thalamus in the feline and primate brain. Electrophysiological and morphological investigations.
Keywords in Hungarian látás, érzőpályák, bazális ganglionok, superior colliculus, thalamus
Keywords in English vision, sensory pathways, basal ganglia, colliculus superior, thalamus
Discipline
Neuroanatomy and neurophysiology (Council of Medical and Biological Sciences)60 %
Analysis, modelling and simulation of biological systems (Council of Medical and Biological Sciences)30 %
Biological basis of neurological and psychiatric disorders (Council of Medical and Biological Sciences)10 %
Panel Neurosciences
Department or equivalent Department of Physiology (University of Szeged)
Participants Berényi, Antal
Braunitzer, Gábor
Gombkötő, Péter
Hajdúné Petrovszki, Zita
Horváth, Gyöngyi
Janáky, Márta
Kékesi, Gabriella
Kéri, Szabolcs
Nagy, Anett
Nagy, Attila
Rokszin, Alice
Starting date 2011-07-01
Closing date 2016-06-30
Funding (in million HUF) 23.840
FTE (full time equivalent) 11.75
state running project





 

Final report

 
Results in Hungarian
A pathway to the basal ganglia including the posterior thalamus and superior colliculus. Electrophysiological and anatomical studies Our project was to study parallel processing of sensory information. We attempted to prove the hypothesis that the sensory information that reaches the basal ganglia basically of tectal origin. In this aspect, the most remarkable result of ours was the introduction of awake, eye movement controlled behaving cat preparate that can substitute the anaesthetized, immobilizes animals in the experiments. We regard it as great importance the new rat strain of ours that has similar hehavioural properties as schizophrenic patients display. Besides these, other forms of parallel information processing were studied, too. The range of our experiments was rather wide it extended to four species: humans, cats, rhesus monkeys and rats were either our experimental subjects. During the time of the grant we published 29 full-paper, English language publications. Seven PhD diplomas were earned by our students.
Results in English
A basalis ganglionok a colliculus superior-t és a hátsó thalamus-t magában foglaló pályája. Elektrofiziologiai és anatómiai tanulmányok. Projektünk tárgya a szenzoros információ párhuzamos szerveződésének vizsgálata volt. Kísérleteinkben megpróbáltuk azt a hypothesist bizonyítani, hogy a basalis ganglionokat elérő szenzoros információ alapjában véve tectális eredetű. Ebből a szempontból legértékesebb eredményünknek az éber, szemmozgás ellenőrzött viselkedő macskapreparátum bevezetését tartjuk, amellyel helyettesíteni lehetne az eddig használt, altatott, immobilizált állatkisérleteket. Nagy jelentőségűnek tartjuk egy új patkányfajta kialakítását, amelynek magatartási tulajdonságai sok szempontban hasonlítanak a schizophren betegekéhez. Emellett a parallel információfeldolgozás más formáit is tanulmányoztuk. A kisérleteket széles körben végeztük, négy speciesre terjedtek ki kisérleteink: ember, macska, majom és patkány volt kísérleteink alanya. A pályázat tartama alatt 29 teljes szövegű, angol nyelvű közlemény jelent meg és hét PhD diplomát szereztek hallgatóink.
Full text https://www.otka-palyazat.hu/download.php?type=zarobeszamolo&projektid=83810
Decision
Yes





 

List of publications

 
Braunitzer G, Keri S, Benedek G, Őze A, Nagy T, Nagy A: Motion transparency-do we need the primary visual cortex?, Society for Neuroscience 41st Annual Meeting, Washington, USA, November 12-16, 2011
Gombkötő P, Berényi A, Benedek G, Nagy A: Optic flow detection in the caudate nucleus of the primate., Society for Neuroscience 41st Annual Meeting, Washington, USA, November 12-16, 2011
Nagy AJ, Gulya K, Benedek G, Nagy A: Tecto-thalamo-striatal visual pathway in the primate., IBRO International Workshop, Szeged, Hungary, 19-21 January, 2012
ROKSZIN A, GOMBKÖTO P, BERÉNYI A, MÁRKUS Z, BRAUNITZER G, BENEDEK G, NAGY A: Visual stimulation synchronizes or desynchronizes the activity of neuron pairs between the caudate nucleus and the posterior thalamus., Brain Res 1418: 52-63, 2011
GOMBKÖTŐ P, ROKSZIN A, BERÉNYI A, BRAUNITZER G, UTASSY G, BENEDEK G, NAGY A: Neuronal code of spatial visual information int he caudate nucleus., Neuroscience 182: 225-231, 2011
NAGY AJ, BERÉNYI A, GULYA K, NORITA M, BENEDEK G, NAGY A: Direct projection from the visual associative cortex to the caudate nucleus in the feline brain., Neurosci Lett 503: 52-57, 2011
BRAUNITZER G, ROKSZIN A , KÓBOR J , NAGY A , SZTRIHA L, BENEDEK G: Development of visual contour integration in children with migraine without aura., Cephalalgia 31: 1048-1056, 2011
BRAUNITZER G, ROKSZIN A, KÓBOR J, BENEDEK G, NAGY A, KINCSES ZT: Delayed development of visual motion processing in childhood migraine., Cephalalgia 32: 492-496, 2012
GOMBKÖTŐ P, BERÉNYI A, NAGYPÁL T, BENEDEK G, BRAUNITZER G, NAGY A: Co-oscillation and synchronization between the posterior thalamus and the caudate nucleus during visual stimulation, NEUROSCIENCE, 2013
WYPYCH M, WANG C, NAGY A, BENEDEK G, DREHER B, WALESZCZYK WJ: Standardized F1 - A consistent measure of strength of modulation of visual responses to sine-wave drifting gratings, Vision Research, 2012
NAGYPÁL T, GOMBKÖTŐ P, AVERKIN R, PUSKÁS T, BERÉNYI A, BENEDEK G, NAGY A: Responses of various cell types to optic flow in the caudate nucleus of the behaving cat, XIII. MITT Konferencia, Budapest, 2013
Csete G, Szabó N, Rokszin A, Tóth E, Braunitzer G, Benedek G, Vécsei L, Kincses ZT: An investigation of the white matter microstructure in motion detection using diffusion MRI, Brain Res. 1470: 35-42,, 2014
Fejes I, Kocsis PB, Benedek G, Janáky M.: Interocular amplitude and latency differences of pattern ERG and pattern VEP parameters., Optom. Vis. Sci. 91:472-476,, 2014
Petrovszki Z, Adam G, Kekesi G, Tuboly G, Morvay Z, Nagy E, Benedek G, Horvath G.: The effects of juvenile capsaicin desensitization in rats: behavioral impairments., Physiol. Behav. 125: 38-44,, 2014
Janáky M, Braunitzer G, Benedek G, Vörös E, Kocsis BP, Clamp MF, Fu AD: Diagnostic and therapeutic challenges., Retina 34: 408-413,, 2014
Janáky M, Borbély J, Benedek G, Kocsis BP, Braunitzer G: Achromatic luminance contrast sensitivity in X-linked color-deficient observers: an addition to the debate., Vis. Neurosci. 31: 99-103,, 2014
Kelemen O, Kiss I, Benedek G, Kéri S: Perceptual and cognitive effects of antipsychotics in first-episode schizophrenia: the potential impact of GABA concentration in the visual cortex., Prog Neuropsychopharmacol Biol Psychiatry. 47:13-19,, 2013
Kóbor J, Nyári T, Benedek G, Túri S.: Age-related prevalence and features of migraine headache in Hungarian schoolchildren and adolescents., Eur J Paediatr Neurol. 17: 600-607,, 2013
Nagypál T, Gombkötő P, Utassy G, Averkin RG, Benedek G, Nagy A: A new, behaving, head restrained, eye movement-controlled feline model for chronic visual electrophysiological recordings., J Neurosci Methods 221: 1-7,, 2014
Wypych M, Nagy A, Mochol G, Foik A, Benedek G, Waleszczyk WJ: Spectral characteristics of phase sensitivity and discharge rate of neurons in the ascending tectofugal visual system, PLOSOne (Közlésre elfogadva), 2014
Nagypál T, Gombkötő P, Averkin RG, Puskás T, Berényi A, Benedek G, Nagy A: Neuronal responses to stationary and dynamic visual stimulation of the caudate nucleus in behaving cat., IBRO Workshop 2014, 16-17 January, Debrecen, Hungary 2014, P47, 2014
Braunitzer G, Nagy A, Őze A, Nagy T, Puszta A, Benedek G, Kéri S: Flickering licht stimulation affectsglobal form detection but not global motion detection., IBRO Workshop 2014, 16-17 January, Debrecen, Hungary 2014, P23, 2014
Nagy A, Nagypál T, Gombkötő P, Benedek G: Tectal multisensory loop of the basal ganglia., 9th FENS Forum of Neuroscience, 5-9 July 2014, Milano, Italy, P1391, 2014
Kekesi G, Petrovszki Z, Benedek G, Horvath G: Sex-specific alterations in behavioral and cognitive functions in a "three hit" animal model of schizophrenia, BEHAVIOURAL BRAIN RESEARCH 284: pp. 85-93., 2015
Safrany-Fark A, Petrovszki Z, Kekesi G, Liszli P, Benedek G, Keresztes C, Horvath G: In vivo potency of different ligands on voltage-gated sodium channels, EUROPEAN JOURNAL OF PHARMACOLOGY 762: pp. 158-164., 2015
A Safrany-Farka, Z Petrovszki, G Kekesi, C Keresztes, G Benedek, G Horvath: Telemetry monitoring for non-invasive assessment of changes in core temperature after spinal drug administration in freely moving rats, JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 72: pp. 19-25., 2015
Halmos KC, Gyarmati P, Xu H, Maimaiti S, Jancso G, Benedek G, Smith BN: Molecular and functional changes in glucokinase expression in the brainstem dorsal vagal complex in a murine model of type 1 diabetes., NEUROSCIENCE 306: pp. 115-122., 2015
Nagypal T, Gombkoto P, Barkoczi B, Benedek G, Nagy A: Activity of Caudate Nucleus Neurons in a Visual Fixation Paradigm in Behaving Cats., PLOS ONE 10:(11) p. e0142526., 2015
Deák K, Fejes I, Janáky M, Várkonyi T, Benedek G, Braunitzer G.: Further Evidence for the Utility of Electrophysiological Methods for the Detection of Subclinical Stage Retinal and Optic Nerve Involvement in Diabetes, Med Princ Pract. 2015 Nov 4. [Epub ahead of print], 2015
Braunitzer G, Őze A, Nagy T, Eördegh G, Puszta A, Benedek G, Kéri S, Nagy A: The effect of simultaneous Flickering light stimulation on global form and motion perception thresholds., Neurosci. Lett. 583:98-91, 2014
Horvath G, Kekesi G, Petrovszki Z, Benedek G,: Abnormal Motor Activity and Thermoregulation in a Schizophrenia Rat Model for Translational Science., PlosOne 10(12): e0143751. doi: 10.1371/journal.pone.0143751. eCollection 2015, 2015
Horvath G, Petrovszki Z, Kekesi G, Tuboly G, Bodosi B, Horvath J, Gombkoto P, Benedek G, Nagy A,: Electrophysiological alterations in a complex rat model of schizophrenia., Behav. Brain Res. 307: 65-72,, 2016
Őze A, Nagy A, Benedek G, Bodosi B, Kéri S, Pálinkás E, Bihari K, Braunitzer G.: Acquired Equivalence and Related Memory Processes in Migraine Without Aura., Cephalalgia in press, 2016
Benedek G: Mechanisms of paralelel information processing in the visual system, Neuro-Ophtalmology, Springer, pp. 9-14., 2016
Kéri S, Szamosi A, Benedek G, Kelemen O: How does the hippocampal formation mediate memory for stimuli processed by the magnocellular and parvocellular visual pathways? Evidence from the comparison of schizophrenia and amnestic mild cognitive impairment (aMCI)., Neuropsychologia, 50: 3193-3199, 2012
Tuboly G, Rudas L, Csillik A, Nagy A, Benedek K, Benedek G, Braunitzer G: Haemodynamic parameters and congitive function during modeled acute volume loss, Acta Physiol. Hu. 99: 118-125, 2012
Petrovszki Z, Kovacs G, Tömböly C, Benedek G, Horvath G: Effects of peptide and lipid endocannabinoids on arthritic pain at spinal level, Anesth. Analg. 114: 1346-1352, 2012
Keri S, Benedek G: Why is vision impaired in fragile X premutation carriers? The role of fragile X mental retardation protein and potential FMR1 mRNA toxicity., Neuroscience 206: 183-189, 2012
Petrovszki Z, Adam G, Tuboly G, Kekesi G, Benedek G, Keri S, Horvath G: Characterization of gene-environment interactions by behavioral profiling of selectively bred rats: the effect of NMDA receptor inhibition and social isolation, Behav. Brain Res. 240: 134-145, 2013
Horvath G., Joo G., Kekesi G., Farkas I., Tuboly G., Petrovszki Z., Benedek G.: Inhibition of itch-related responses at spinal level in rats., Acta Physiol. Hung. 98(4):479-489, 2011





 

Events of the project

 
2015-03-24 23:34:29
Résztvevők változása
2013-11-21 14:46:27
Résztvevők változása




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