Kapcsolatok a lipid metabolizmus és a DNS repair rendszer között - a stresszválasz és a metabolizmus kapcsoalta  részletek

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Projekt adatai

  
azonosító
123975
típus K
Vezető kutató Bay Péter
magyar cím Kapcsolatok a lipid metabolizmus és a DNS repair rendszer között - a stresszválasz és a metabolizmus kapcsoalta
Angol cím New connections between lipid metabolism and DNA repair – how to integrate stress into metabolism
magyar kulcsszavak PARP-2, lipid metabolizmus, SREBP, szteroid, mitokondrium
angol kulcsszavak PARP-2, lipid metabolism, SREBP, steroid, mitochondria
megadott besorolás
Anyagcsere (Orvosi és Biológiai Tudományok Kollégiuma)100 %
zsűri Élettan, Kórélettan, Gyógyszertan és Endokrinológia
Kutatóhely ÁOK Orvosi Vegytani Intézet (Debreceni Egyetem)
résztvevők Jankó Laura
Kiss Borbála
Kovács Tünde
Márton Judit
Molnár Zsuzsanna
Nagy Lilla Nikoletta
Sári Zsanett Mercédesz
Tóth Attila
projekt kezdete 2017-12-01
projekt vége 2022-11-30
aktuális összeg (MFt) 47.920
FTE (kutatóév egyenérték) 12.63
állapot aktív projekt





 

Zárójelentés

  
kutatási eredmények (magyarul)
A PARP enzimeket először DNS repair feférjékként írták le, a projekt keretében a lipid metabolizmusban betöltött szerepüket vizsgáltuk. Eredményeink a PARP1, PARP2 és PARP10 enzimek lipid metabolizmusban betöltött szerepére mutattak rá. Ezen enzimek csendesítése, deléciója vagy farmakológiai gátlása indukálja a mitokondriális lipid oxidációt, a koleszrerin bioszintézist és a steroid, pontosabban a tesztoszteron bioszintézist. A lipid metabolizmus változásai miatt megváltozik a biomembránok összetétele és fluiditása. A PARP1 és a PARP2 enzimek gátolják az autofágiát és a lipofágiát, illetve, emiatt az oxidatív anyagcseréhez rendelkezésre álló szubsztrátokat. Szélesebb perspektívából a PARP enzimek olyan negatív visszacsatolásokban játszanak szerepet, ahol a PARP enzimek aktivitásot lipid specieszek szabályozzák, míg a PARP aktivitás ezen specieszek szintézisét befolyásolja. Kimutattuk, hogy a PARP gátlás során bekövetkező mitokondriális biogenezisben kulcsszerepe van a reaktív (oxigén) intermedierek termelődésének és a ROS-ok mitokondriális fragmentációt okoznak. Azonosítottunk egy az UVB-indukált CPD dimerekről kiinduló jelpályát, ami a keratinociták túlélését segíti elő, azonban, lehetővé teszi, hogy a DNS mutációk továbbadódjanak és így emeli a malignizálódás kockázatát. Összességében a projekt eredményei arra mutatnak rá, hogy a PARP enzimek a külső stressz faktorok által aktivált metabolikus diszruptorként működnek.
kutatási eredmények (angolul)
PARP enzymes are key DNA repair enzymes with roles in metabolic regulation and in the frame of that project we assessed the role of PARPs in lipid metabolism. We evidenced a role for PARP1, PARP2 and PARP10 in multiple model systems in lipid metabolism. Silencing, deletion or pharmacological inhibition of PARPs induce mitochondrial lipid oxidation, cholesterol biosynthesis and subsequently enhance steroidogenesis and testosterone biosynthesis. Changes to lipid metabolism change the composition and fluidity of biomembranes. Activation of PARP1 and PARP2 inhibited autophagy and lipophagy and reduced substrate supply for cellular oxidative metabolism. On a broader scale, we identified negative feedback loops, where the activity of PARP enzymes were lipid species and, in turn, PARP enzymes regulated lipid biosynthetic pathways. We showed that PARP inhibition induces mitochondrial biogenesis through reactive species-mediated retrograde signaling but induced mitochondrial fragmentation. We identified a novel signaling pathway in UVB-irradiated keratinocytes that stems from the UVB-elicited CPDs in DNA and induce mitochondrial biogenesis and mitochondrial oxidation to support cell survival. This mechanism likely support the carryover of mutations in UVB-irradiated keratinocytes and, hence, enhance the risk of malignancies. Taken together, our results highlighted PARP enzymes are transducers of external stress into metabolism and are metabolic disruptors.
a zárójelentés teljes szövege https://www.otka-palyazat.hu/download.php?type=zarobeszamolo&projektid=123975
döntés eredménye
igen





 

Közleményjegyzék

  
Simon Á, Némenth J, Jávor A, Komlósi I, Bai P, Oláh J, Juhász B, Kiss R, Szilvássy Z, Czeglédi L: Feeding state and age dependent changes in melanin-concentrating hormone expression in the hypothalamus of broiler chickens., Acta Biochimica Polonica 65(2):251-258, 2018
Simon Á, Jávor A, Bai P, Oláh J, Czeglédi L: ) Reference gene selection for reverse transcription quantitative polymerase chain reaction in chicken hypothalamus under different feeding regimes., Journal of Animal Physiology and Animal Nutrition, 102(1):286-296, 2018
Márton J, Fodor T, Nagy L, Vida A, Kis G, Brunyánszki A, Antal M, Lüscher B, Bai P: PARP10 (ARTD10) modulates mitochondrial function., PLoS One, 13(1):e0187789, 2018
Vida A, Kardos G, Kovács T, Bodrogi BL, Bai P: The deletion of PARP1 changes the composition of the microbiome in the gut, Molecular Medicine Reports, 18(5):4335-4341, 2018
Mikó E, Vida A, Kovács T, Ujlaki Gy, Trencsényi Gy, Márton J, Sári Zs, Kovács P, Boratkó A, Hujber Z, Csonka T, Antal-Szalmás P, Watanabe M, Gombos I, Csoka B, Kiss B, Vígh L, Szabó J, Méhes G, Sebestyén A, Goedert JJ, Bai P: Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness., BBA – Bioenergetics 1859(9):958-974., 2018
Márton J, Péter M, Balogh G, Bódi B, Vida A, Szántó M, Bojcsuk D, Jankó L, Bhattoa Harjit P, Gombos I, Uray K, Horvath I, Török Zs, Bálint BL, Papp Z, Vígh L, Bai P: Poly(ADP-ribose) polymerase-2 is a lipid-modulated modulator of muscular lipid homeostasis., – Molecular and Cell Biology of Lipids 1863:1399-1422, 2018
Kovács T, Mikó E, Vida A, Sebő É, Toth J, Csonka T, Boratkó A, Ujlaki G, Lente G, Kovács P, Tóth D, Árkosy P, Kiss B, Méhes G, Goedert JJ, Bai P: Cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors., Scientific Reports in press DOI:10.1038/s41598-018-37664-7, 2019
P (29%), Goedert JJ (7%), Kovacs T (6%), Miko E (29%), Vida A (29%): METHODS FOR DIAGNOSING BREAST CANCER, PCT/HU2018/050027, 2018
Bai P (23%), Goedert JJ (4%), Kovacs T (23%), Miko E (23%), Sebő É (2%), Tóth J (2%), Vida A (23%): Treatment and diagnosis of breast cancer, P1800271, 2018
Simon Á, Gulyás G, Mészár Z, Bhide M, Oláh J, Bai P, Csősz É, Jávor A, Komlósi I, Remenyik J, Czeglédi L: Proteomics alterations in chicken jejunum caused by 24 h fasting., PEERJ 7:e6588, 2019
Kristof E, Kulsoczki A, Veress R, Shaw A, Combi ZS, Varga K, Gyory F, Balajthy Z, Bai P, Bacso Z, Fesus L: Ilnterleukin-6 released from differentiating human beige adipocytes improves browning., BBA-Experimental Cell Research 377(1-2):47-55., 2019
Mikó E, Kovács T, Sebő É, Tóth J, Csonka T, Ujlaki G, Sipos A, Szabó J, Méhes G, Bai P: Microbiome – microbial metabolome – cancer cell interactions in breast cancer – familiar, but unexplored, Cells 8:293, 2019
Nagy L, Rauch B, Balla N, Ujlaki G, Kis G, Abdul-Rahman O, Kristóf E, Sipos A, Antal M, Tóth A, Debreceni T, Horváth A, Maros T, Csizmadia P, Szerafin T, Bai P: Olaparib induces browning of in vitro cultures of human primary white adipocytes., Biochemical Pharmacology 167:76-85., 2019
Szántó M, Dózsa A, Antal D, Szabó K, Kemény L, Bai P: Targeting the gut-skin axis – probiotics as new tools for skin disorder management?, Experimental Dermatology 28(11):1210-1218., 2019
Kovács P, Csonka T, Kovács T, Sári Z, Ujlaki G, Sipos A, Karányi Z, Szeőcs D, Hegedűs C, Uray K, Jankó L, Kiss M, Kiss B, Laoui D, Virág L, Méhes G, Bai P, Mikó E: Lithocholic acid, a metabolite of the microbiome, increases oxidative stress in breast cancer., Cancers 11(9):1255, 2019
Kiss B, Szántó M, Hegedűs C, Antal D, Szödényi A, Márton J, Méhes G, Virág L, Szegedi A, Bai P: Poly(ADP-ribose) polymerase-1 depletion enhances the severity of inflammation in an imiquimod-induced model of psoriasis., Experimental Dermatology 29(1):79-85., 2020
Hegedűs Cs, Boros G, Fidrus E, Kis GN, Antal M, Juhász T, Janka EA, Jankó L, Paragh G, Emri G, Bai P, Remenyik É: PARP1 Inhibition Augments UVB-Mediated Mitochondrial Changes – Implications for UV-Induced DNA Repair and Photocarcinogenesis, Cancers 12(1):5, 2020
Szántó M, Bai P: The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolism, Genes and Development doi: 10.1101/gad.334284.119., 2020
Smolková K, Mikó E, Kovács T, Leguina-Ruzzi A, Sipos A, Bai P: NRF2 in regulating cancer metabolism., Antioxidants and Redox Signaling doi: 10.1089/ars.2020.8024., 2020
Jankó L, Sári Z, Kovács T, Kis G, Szántó M, Antal M, Juhász G, Bai P: Silencing of PARP2 blocks autophagic degradation., Cells https://doi.org/10.3390/cells9020380, 2020
Kovács T, Mikó E, Ujlaki G, Sári Z, Bai P: The microbiome as a component of the tumor microenvironment., Tumor Microenvironment – Novel Concepts. Advances in Experimental Medicine and Biology (ISSN:0065-2598). Springer-Nature Ed.: Alexander Birbrair, 2020
Csernus B, Biró S, Babinszky L, Komlósi I, Jávor A, Stündl L, Remenyik J, Bai P, Oláh J, Pesti-Asbóth G, Czeglédi L: Effect of carotenoids, oligosaccharides and anthocyanins on growth performance, immunological parameters and intestinal morphology in broiler chickens challenged with Esc, Animals 10(2), 347, 2020
Vida A, Bodrogi BL, Balogh B, Bai P: Taxamat: Automated Biodiversity Data Management Tool – implications for microbiome studies, Physiology International 1, 12-17., 2020
Kiss B, Mikó E, Sebő É, Toth J, Ujlaki G, Szabó J, Uray K, Bai P, Árkosy P: Oncobiosis and microbial metabolite signaling in pancreatic adenocarcinoma, Cancers, 12(5), 1068, 2020
Curtin N, Bányai K, Thaventhiran J, Le Quesne J, Helyes Z, Bai P: Repositioning PARP inhibitors for SARS-CoV-2 infection (COVID-19); a new multi-pronged therapy for ARDS?, British Journal of Pharmacology 177(16):3635-3645., 2020
Sári Z, Kovács T, Csonka T, Török M, Sebő É, Toth J, Tóth D, Mikó E, Kiss B, Szeőcs D, Uray K, Karányi Z, Kovács I, Méhes G, Árkosy P, Bai P: Fecal expression of E. coli lysine decarboxylase (LdcC) is downregulated in E-cadherin negative lobular breast carcinoma, Physiology International DOI: 10.1556/2060.2020.00016, 2020
Szabó Z, Marosvölgyi T, Szabó É, Bai P, Figler M, Verzár Z: The potential beneficial effect of EPA and DHA supplementation managing cytokine storm in COVID-19, Frontiers in Physiology 11:752., 2020
Nagy L, Béke F, Juhász L, Kovács T, Juhász-Tóth É, Docsa T, Tóth A, Gergely P, Somsák L, Bai P: Glycogen phosphorylase inhibitor, 2,3‐bis[(2E)‐3‐(4‐hydroxyphenyl)prop‐2‐enamido] butanedioic acid (BF142), improves baseline insulin secretion of MIN6 insulinoma cells, PLOS One 15(9):e0236081., 2020
Méhes G, Matolay O, Beke L, Czenke M, Pórszász R, Mikó E, Bai P, Berényi E, Trencsényi G: Carbonic anhydrase inhibitor acetazolamide enhances CHOP treatment response and stimulates effector T-cell infiltration in A20/BalbC murine B-cell lymphoma, International Journal of Molecular Sciences 21(14):E5001., 2020
Sári Zs, Mikó E, Kovács T, Jankó L, Csonka T, Lente G, Sebő É, Toth J, Tóth D, Árkosy P, Boratkó A, Ujlaki Gy, Török M, Kovács I, Szabó J, Kiss B, Méhes G, Goedert JJ, Bai P: Indolepropionic acid, a metabolte of the microbiome, has cytostatic properties in breast cancer by activating AHR and PXR receptors and inducing oxidative stress., Cancers, 12(9):2411., 2020
M, Bánhegyi V, Bódi B, Gyöngyösi A, Kovács Á, Árokszállási A, Hamdani N, Fagyas M, Édes I, Csanádi Z, Czuriga I, Kisvárday Z, Lekli I, Bai P, Tóth A, Papp Z, Czuriga D: Prophylactic, single-drug cardioprotection in a comparative, experimental study of doxorubicin-induced cardiomyopathy., Journal of Translational Medicine 18(1):470, 2020
Sári Zs, Mikó E, Kovács T, Boratkó A, Ujlaki Gy, Jankó L, Kiss B, Uray K, Bai P: Indoxylsufate, a metabolite of the microbiome, has cytostatic effects in breast cancer via activation of AHR and PXR receptors, Cancers 12(10), 2915., 2020
Curtin N, Bai P: PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer, Cancers 12(12):E3494., 2020
Hegedűs C, Juhász T, Fidrus E, Janka EA, Juhász G, Boros G, Paragh G, Uray K, Emri G, Remenyik É, Bai P: Cyclobutane pyrimidine dimers from UVB exposure induce a hypermetabolic state in keratinocytes via mitochondrial oxidative stress., Redox Biology doi: 10.1016/j.redox.2020.101808., 2020
Bai P (23%), Kovács T (23%), Mikó E (23%), Sári Zs (23%), Goedert JJ (4%), Tóth J (42%), Sebő É (2%): TREATMENT AND DIAGNOSIS OF BREAST CANCER., under review, 2020
Hegedűs C, Juhász T, Fidrus E, Janka EA, Juhász G, Boros G, Paragh G, Uray K, Emri G, Remenyik É, Bai P: Cyclobutane pyrimidine dimers from UVB exposure induce a hypermetabolic state in keratinocytes via mitochondrial oxidative stress., Redox Biology 38:101808, 2021
Smolkova K, Bai P: Editorial: Epithelial-Mesenchymal Transition: Yet Another Exciting Avenue in Cancer Metabolic Remodeling, Frontiers in Oncology 10:628664., 2021
Sipos A, Ujlaki G, Mikó E, Maka E, Szabó J, Uray K, Krasznai ZT, Bai P: The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling., Molecular Medicine 27(1):33, 2021
Kiss B, Mikó E, Sebő É, Tóth J, Ujlaki G, Szabó J, Uray K, Bai P, Árkosy P: Onkobiózis és mikrobiális metabolikus jelátvitel pancreas adenocarcinomában, Gasztroenterológiai szemle (Central European Journal of Gastroenterology) 7(2):57-65, 2021
Jankó L, Kovács T, Laczik M, Sári Z, Ujlaki G, Kis G, Horváth I, Antal M, Vígh L, Bálint BL, Uray K, Bai P: Silencing of poly(ADP-ribose) polymerase-2 induces mitochondrial reactive species production and mitochondrial fragmentation, Cells 10(6):1387, 2021
Szántó M, Gupte R, Kraus LW, Pacher P, Bai P: PARPs in lipid metabolism and related diseases, Progress in Lipid Research 84:101117, 2021
Kacsir I, Sipos A, Ujlaki G, Buglyó P, Somsák L, Bai P, Bokor E,: Ruthenium half-sandwich type complexes with bidentate monosaccharide ligands show antineoplastic activity in ovarian cancer cell models through reactive oxygen species pr, International Journal of Molecular Medicine 22:10454, 2021
Simon Á, Némenth J, Jávor A, Komlósi I, Bai P, Oláh J, Juhász B, Kiss R, Szilvássy Z, Czeglédi L: Feeding state and age dependent changes in melanin-concentrating hormone expression in the hypothalamus of broiler chickens., Acta Biochimica Polonica 65(2):251-258, 2018
Simon Á, Jávor A, Bai P, Oláh J, Czeglédi L: ) Reference gene selection for reverse transcription quantitative polymerase chain reaction in chicken hypothalamus under different feeding regimes., Journal of Animal Physiology and Animal Nutrition, 102(1):286-296, 2018
Vida A, Kardos G, Kovács T, Bodrogi BL, Bai P: The deletion of PARP1 changes the composition of the microbiome in the gut, Molecular Medicine Reports, 18(5):4335-4341, 2018
Mikó E, Vida A, Kovács T, Ujlaki Gy, Trencsényi Gy, Márton J, Sári Zs, Kovács P, Boratkó A, Hujber Z, Csonka T, Antal-Szalmás P, Watanabe M, Gombos I, Csoka B, Kiss B, Vígh L, Szabó J, Méhes G, Sebestyén A, Goedert JJ, Bai P: Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness., BBA – Bioenergetics 1859(9):958-974., 2018
Márton J, Péter M, Balogh G, Bódi B, Vida A, Szántó M, Bojcsuk D, Jankó L, Bhattoa Harjit P, Gombos I, Uray K, Horvath I, Török Zs, Bálint BL, Papp Z, Vígh L, Bai P: Poly(ADP-ribose) polymerase-2 is a lipid-modulated modulator of muscular lipid homeostasis., – Molecular and Cell Biology of Lipids 1863:1399-1422, 2018
Kovács T, Mikó E, Vida A, Sebő É, Toth J, Csonka T, Boratkó A, Ujlaki G, Lente G, Kovács P, Tóth D, Árkosy P, Kiss B, Méhes G, Goedert JJ, Bai P: Cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors., Scientific Reports 9(1):1300, 2019
Simon Á, Gulyás G, Mészár Z, Bhide M, Oláh J, Bai P, Csősz É, Jávor A, Komlósi I, Remenyik J, Czeglédi L: Proteomics alterations in chicken jejunum caused by 24 h fasting., PEERJ 7:e6588, 2019
Kristof E, Kulsoczki A, Veress R, Shaw A, Combi ZS, Varga K, Gyory F, Balajthy Z, Bai P, Bacso Z, Fesus L: Ilnterleukin-6 released from differentiating human beige adipocytes improves browning., BBA-Experimental Cell Research 377(1-2):47-55., 2019
Mikó E, Kovács T, Sebő É, Tóth J, Csonka T, Ujlaki G, Sipos A, Szabó J, Méhes G, Bai P: Microbiome – microbial metabolome – cancer cell interactions in breast cancer – familiar, but unexplored, Cells 8:293, 2019
Nagy L, Rauch B, Balla N, Ujlaki G, Kis G, Abdul-Rahman O, Kristóf E, Sipos A, Antal M, Tóth A, Debreceni T, Horváth A, Maros T, Csizmadia P, Szerafin T, Bai P: Olaparib induces browning of in vitro cultures of human primary white adipocytes., Biochemical Pharmacology 167:76-85., 2019
Szántó M, Dózsa A, Antal D, Szabó K, Kemény L, Bai P: Targeting the gut-skin axis – probiotics as new tools for skin disorder management?, Experimental Dermatology 28(11):1210-1218., 2019
Kiss B, Szántó M, Hegedűs C, Antal D, Szödényi A, Márton J, Méhes G, Virág L, Szegedi A, Bai P: Poly(ADP-ribose) polymerase-1 depletion enhances the severity of inflammation in an imiquimod-induced model of psoriasis., Experimental Dermatology 29(1):79-85., 2020
Hegedűs Cs, Boros G, Fidrus E, Kis GN, Antal M, Juhász T, Janka EA, Jankó L, Paragh G, Emri G, Bai P, Remenyik É: PARP1 Inhibition Augments UVB-Mediated Mitochondrial Changes – Implications for UV-Induced DNA Repair and Photocarcinogenesis, Cancers 12(1):5, 2020
Szántó M, Bai P: The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolism, Genes and Development 34(5-6):321-340, 2020
Smolková K, Mikó E, Kovács T, Leguina-Ruzzi A, Sipos A, Bai P: NRF2 in regulating cancer metabolism., Antioxidants and Redox Signaling 33(13):966-997, 2020
Jankó L, Sári Z, Kovács T, Kis G, Szántó M, Antal M, Juhász G, Bai P: Silencing of PARP2 blocks autophagic degradation., Cells 9(2):380, 2020
Csernus B, Biró S, Babinszky L, Komlósi I, Jávor A, Stündl L, Remenyik J, Bai P, Oláh J, Pesti-Asbóth G, Czeglédi L: Effect of carotenoids, oligosaccharides and anthocyanins on growth performance, immunological parameters and intestinal morphology in broiler chickens challenged with..., Animals 10(2), 347, 2020
Vida A, Bodrogi BL, Balogh B, Bai P: Taxamat: Automated Biodiversity Data Management Tool – implications for microbiome studies, Physiology International 1, 12-17., 2020
Kiss B, Mikó E, Sebő É, Toth J, Ujlaki G, Szabó J, Uray K, Bai P, Árkosy P: Oncobiosis and microbial metabolite signaling in pancreatic adenocarcinoma, Cancers, 12(5), 1068, 2020
Curtin N, Bányai K, Thaventhiran J, Le Quesne J, Helyes Z, Bai P: Repositioning PARP inhibitors for SARS-CoV-2 infection (COVID-19); a new multi-pronged therapy for ARDS?, British Journal of Pharmacology 177(16):3635-3645., 2020
Sári Z, Kovács T, Csonka T, Török M, Sebő É, Toth J, Tóth D, Mikó E, Kiss B, Szeőcs D, Uray K, Karányi Z, Kovács I, Méhes G, Árkosy P, Bai P: Fecal expression of E. coli lysine decarboxylase (LdcC) is downregulated in E-cadherin negative lobular breast carcinoma, Physiology International 107(2):349-358, 2020
Szabó Z, Marosvölgyi T, Szabó É, Bai P, Figler M, Verzár Z: The potential beneficial effect of EPA and DHA supplementation managing cytokine storm in COVID-19, Frontiers in Physiology 11:752., 2020
Nagy L, Béke F, Juhász L, Kovács T, Juhász-Tóth É, Docsa T, Tóth A, Gergely P, Somsák L, Bai P: Glycogen phosphorylase inhibitor, 2,3‐bis[(2E)‐3‐(4‐hydroxyphenyl)prop‐2‐enamido] butanedioic acid (BF142), improves baseline insulin secretion of MIN6 insulinoma cells, PLOS One 15(9):e0236081., 2020
Méhes G, Matolay O, Beke L, Czenke M, Pórszász R, Mikó E, Bai P, Berényi E, Trencsényi G: Carbonic anhydrase inhibitor acetazolamide enhances CHOP treatment response and stimulates effector T-cell infiltration in A20/BalbC murine B-cell lymphoma, International Journal of Molecular Sciences 21(14):E5001., 2020
Sári Zs, Mikó E, Kovács T, Jankó L, Csonka T, Lente G, Sebő É, Toth J, Tóth D, Árkosy P, Boratkó A, Ujlaki Gy, Török M, Kovács I, Szabó J, Kiss B, Méhes G, Goedert JJ, Bai P: Indolepropionic acid, a metabolte of the microbiome, has cytostatic properties in breast cancer by activating AHR and PXR receptors and inducing oxidative stress., Cancers, 12(9):2411., 2020
M, Bánhegyi V, Bódi B, Gyöngyösi A, Kovács Á, Árokszállási A, Hamdani N, Fagyas M, Édes I, Csanádi Z, Czuriga I, Kisvárday Z, Lekli I, Bai P, Tóth A, Papp Z, Czuriga D: Prophylactic, single-drug cardioprotection in a comparative, experimental study of doxorubicin-induced cardiomyopathy., Journal of Translational Medicine 18(1):470, 2020
Sári Zs, Mikó E, Kovács T, Boratkó A, Ujlaki Gy, Jankó L, Kiss B, Uray K, Bai P: Indoxylsufate, a metabolite of the microbiome, has cytostatic effects in breast cancer via activation of AHR and PXR receptors, Cancers 12(10), 2915., 2020
Curtin N, Bai P: PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer, Cancers 12(12):E3494., 2020
Hegedűs C, Juhász T, Fidrus E, Janka EA, Juhász G, Boros G, Paragh G, Uray K, Emri G, Remenyik É, Bai P: Cyclobutane pyrimidine dimers from UVB exposure induce a hypermetabolic state in keratinocytes via mitochondrial oxidative stress., Redox Biology 38:101808, 2021
Bai P (23%), Kovács T (23%), Mikó E (23%), Sári Zs (23%), Goedert JJ (4%), Tóth J (42%), Sebő É (2%): TREATMENT AND DIAGNOSIS OF BREAST CANCER., under PCT evaluation, 2020
Smolkova K, Bai P: Editorial: Epithelial-Mesenchymal Transition: Yet Another Exciting Avenue in Cancer Metabolic Remodeling, Frontiers in Oncology 10:628664., 2021
Sipos A, Ujlaki G, Mikó E, Maka E, Szabó J, Uray K, Krasznai ZT, Bai P: The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling., Molecular Medicine 27(1):33, 2021
Jankó L, Kovács T, Laczik M, Sári Z, Ujlaki G, Kis G, Horváth I, Antal M, Vígh L, Bálint BL, Uray K, Bai P: Silencing of poly(ADP-ribose) polymerase-2 induces mitochondrial reactive species production and mitochondrial fragmentation, Cells 10(6):1387, 2021
Szántó M, Gupte R, Kraus LW, Pacher P, Bai P: PARPs in lipid metabolism and related diseases, Progress in Lipid Research 84:101117, 2021
Kacsir I, Sipos A, Ujlaki G, Buglyó P, Somsák L, Bai P, Bokor E,: Ruthenium half-sandwich type complexes with bidentate monosaccharide ligands show antineoplastic activity in ovarian cancer cell models through reactive oxygen species pr, International Journal of Molecular Medicine 22:10454, 2021
Kovács T, Mikó E, Ujlaki G, Yousef H, Csontos V, Uray K, Bai P: The involvement of oncobiosis and bacterial metabolite signaling in metastasis formation in breast cancer, Cancer and Metastasis Reviews 40(4):1223-1249, 2021
acsir I, Sipos A, Bényei A, Janka E, Buglyó P, Somsák L, Bai P, Bokor É: Reactive oxygen species production is responsible for antineoplastic activity of osmium, ruthenium, iridium and rhodium half-sandwich type complexes with bidentate glycosyl heterocyclic ligands in various cancer cell models, International Journal of Molecular Medicine 23(2):813, 2021
Antal D, Alimohammadi S, Bai P, Szöllősi AG, Szántó M: Antigen-presenting cells in psoriasis., Life 12(2):234, 2022
Balázs B, Tóth Z, Kacsir I, Sipos A, Buglyó P, Somsák L, Bokor É, Kardos G, Bai P: Targeting multiresistant Gram-positive bacteria by ruthenium, osmium, iridium and rhodium half-sandwich type complexes with bidentate monosaccharide ligands., Frontiers in Chemistry 10:868234, 2022
Rezen T, Rozman D, Kovács T, Kovács P, Sipos A, Bai P, Mikó E: The role of bile acids in carcinogenesis., Cellular and Molecualr Life Sciences 79(5):243, 2022
Lénárt K, Bankó C, Újlaki G, Póliska S, Kis G, Csősz É, Antal M, Bacsó Z, Bai P, Fésüs L, Mádi A: Tissue transglutaminase knock-out preadipocytes and beige cells of epidydimal fat origin possess decreased mitochondrial functions required for thermogenesis., International Journal of Molecular Medicine 23(9):5175, 2022
Antal D, Janka EA, Szabó J, Szabó IL, Szegedi A, Gáspár K, Bai P, Szántó M: Culture-based analyses of skin bacteria in lesional moist, and unaffected dry and sebaceous skin regions of Hidradenitis Suppurativa patients., Journal of the European Academy of Dermatology and Venereology 36(9):e731-e733, 2022
Papp H, Bóvári-Biri J, Bánfai K, Juhász P, Mahdi M, Russo LC, Bajusz D, Sipos A, Petri L, Kemény Á, Madai M, Kuczmog A, Batta G, Mózner O, Vaskó D, Hirsch E, Bohus P, Méhes G, Tőzsér J, Curtin NJ, Helyes Z, Tóth A, Hoch NC, Jakab F, Keserű GM, Pongrácz JE, Bai P: Rucaparib blocks SARS-CoV-2 virus binding to cells and interleukin-6 release in a model of COVID-19., MedRXiv https://doi.org/10.1101/2022.06.30.22277079, 2022
Nagy L, Rauch B, Szerafin T, Uray K, Tóth A, Bai P: Nicotinamide-riboside shifts the differentiation of human primary white adipocytes to beige adipocytes impacting substrate preference and uncoupling respiration through SIRT1 activation and mitochondria-derived reactive species production., Frontiers Cell and Developmental Biology 10:979330, 2022
Wang L, Wang D, Sonzogni O, Ke S, Wang Q, Thavamani A, Batalini F, Stopka SA, Regan MS, Vandal S, Tian S, Pinto J, Cyr AM, Bret-Mounet V, Baquer G, Eikesdal HP, Yuan M, Asara JM, Heng YJ, Bai P, Agar NYR, Wulf GM: PARP-inhibition reprograms macrophages towards an anti-tumor phenotype., Cell Reports, 41(2):111462., 2022
Fagyas M, Nagy Jr B, Ráduly A, Siket Mányiné I, Mártha L, Erdősi G, Sipka S, Enyedi E, Pólik Z, Kappelmayer J, Papp Z, Borbély A, Szabó T, Balla J, Balla G, Bai P, Bácsi A, Tóth A: The majority of severe COVID-19 patients develop anti-cardiac autoantibodies., Geroscience in press, 2022
Kovács T, Rauch B, Mikó E, Bai P: Methods to assess the role of poly(ADP-ribose) polymerases in regulating mitochondrial oxidative function., Methods in Molecular Biology, in press. Ed: Alexei Tulin, 2023
Bai P, Balázs B, Bokor É, Buglyó P, Kacsir I, Kardos G, Kiss GA, Sipos A, Somsák L: Half sandvich transition metal complexes and uses thereof, submitted for PCT evaluation, 2022




 

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2018-05-07 13:43:19
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