Glucocorticoids and behavioural disorders: a study integrating effects on aggression, anxiety and depression  Page description

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Details of project

 
Identifier
46785
Type K
Principal investigator Haller, József
Title in Hungarian Glukokortikoidok és magatartási rendellenességek: agresszió, szorongás, és depresszió integrált vizsgálata
Title in English Glucocorticoids and behavioural disorders: a study integrating effects on aggression, anxiety and depression
Panel Neurosciences
Department or equivalent Laboratory of Behavioural and Stress Studies (Institute of Experimental Medicine)
Participants Barna, István
Halász, József
Mikics, Éva
Soproni, Krisztina
Starting date 2004-01-01
Closing date 2008-03-31
Funding (in million HUF) 13.416
FTE (full time equivalent) 0.00
state closed project





 

Final report

 
Results in Hungarian
Összehasonlító módon leírtuk az abnormális és normális agresszivitás idegrendszeri hátterét. Kidolgoztuk a stressz által indukált szorongásnak egy új modelljét, és leírtuk ennek idegrendszeri hátterét. Vizsgáltuk a depresszió stresszfüggését, és ennek idegrendszeri hátterét. Mindhárom viselkedési modell esetében (glukokotikoid-függő abnormális agresszió modell, stressz által kiváltott szociális elkerülés modell, szociális alárendeltség által kiváltott depresszió modell) tisztáztuk a glukokortikoidok szerepét. Farmakológiai kísérleteinkben új, potenciális gyógyszercélpontokat azonosítottunk (az NK1 receptort az abnoprmális agresszió esetében, illetve a CB1 receptort a stressz által kiváltott szorongás esetében). Megfigyeléseket tettünk a három magatartási zavar integrált szabályozására vonatkozólag. A projekt keretében végzett vizsgálatokból eddig 22 publikáció született, amelyek összesített impakt faktora megközelíti a 80-at. Az eredményekből még további 4-5 publikáció írását tervezzük. Az eltelt rövid idő alatt (a publikációk jelentős része 2007-ben illetve 2008-ban született) a projekt keretében írt publikációkra több mint 100-szor hivatkoztak.
Results in English
We compared the neural background of normal and abnormal aggression in a model recently developed by us. We developed a new model of stress-induced anxiety, and characterized its neural background. The stress- dependence of depression symptoms was studied in a model involving chronic social submission. The role of glucocorticoids was clarified in all three models (i.e. the glucocorticoid-dependent abnormal aggression model, the stress-induced social avoidance model, and the submission-induced depression model). New pharmacological targets were identified for abnormal aggression and stress-induced anxiety (the NK1 receptor and the cannabinoid CB1 receptor, respectively). We also studied the integrated control of aggression, anxiety and depression. The project lead to 22 publications so far, the cumulative impact factor of which is close to 80. We plan to write 4-5 publications in addition. In the short time elapsed, the above mentioned 22 publications were cited more than 100 times. We mention that many of the publications were written in 2007 and 2008.
Full text https://www.otka-palyazat.hu/download.php?type=zarobeszamolo&projektid=46785
Decision
Yes





 

List of publications

 
Kruk MR, Halasz J, Meelis W, Haller J: Fast positive feedback between the adrenal stress response and a brain mechanism in aggressive behavior, Behav. Neurosci. 118: 1062-1070, 2004, 2004
Haller J, Tóth M, Halász J: The activation of raphe serotonergic neurons in normal and hypoarousal-driven aggression: a double labeling study in rats, Behav Brain Res 161: 88-94, 2005, 2005
Haller J, Mikics É, Tóth M, Halász J: Emotional shifts during aggression - pathway to violence?, Physiol Behav, elfogadva, 2008
Haller J, Horváth Zs, Bakos N.: The effect of buspirone on normal and hypoarousal-driven abnormal aggression in rats, Prog Neuropsychopharmacol Biol Psych 2007; 31: 27-31., 2007
Halasz J, Toth M, Kallo I, Liposits Z, Haller J.: The activation of prefrontal cortical neurons in aggression—A double labeling study., Behav Brain Res 2006; 175: 166-175., 2006
Mikics É, Barsy B, Haller J: The effect glucocorticoids on aggressiveness in established colonies of rats, Horm Behav, 2007; 32: 160-170., 2007
Mikics E, Dombi T, Barsvári B, Varga B, Ledent C, Freund TF, Haller J.: The effects of cannabinoids on contextual conditioned fear in CB1 knockout and CD1 mice., Behav Pharmacol. 2006; 17: 223-230., 2006
Haller J, Mátyás F, Soproni K, Varga B, Barsy B, Németh B, Mikics E, Freund TF, Hájos N.: Correlated species differences in the effects of cannabinoid ligands on anxiety and on GABAergic and glutamatergic synaptic transmission., Eur J Neurosci. 2007; 25: 2445-2456., 2007
Mikics E, Baranyi J, Haller J.: Rats exposed to traumatic stress bury unfamiliar objects - A novel measure of hyper-vigilance in PTSD models?, Physiol Behav. 2008; [Epub ahead of print] PMID: 18339410, 2008
Mikics É, Tóth M, Varjú P, Gereben B, Liposits Z, Ashaber M, Halász J, Barna I, Farkas I, Haller J.: Lasting changes in social behavior and amygdala function after a single exposure to a traumatic stressor., Psychoneuroendocrinology 2008, elfogadva, 2008
Halász J, Zelena D, Tóth M, Haller J: Hypothalamic neurokinin1 receptor positive neurons are crucial for the expression of different emotion-related behavioral patterns, Neuropsychopharmacology 2008, beküldve, 2008
Tóth M, Halász E., Mikics É, Barsy B, Haller J: Early social deprivation induces disturbed social communication and violent aggression in adulthood, Behav. Neurosci. 2008, elfogadva, 2008
Baranyi J, Bakos N, Haller J.: Social instability in female rats: the relationship between stress-related and anxiety-like consequences., Physiol Behav 84: 510-518, 2005, 2005
Haller J, Mikics E, Halasz J, Toth M.: Mechanisms differentiating normal from abnormal aggression: Glucocorticoids and serotonin, Eur J Pharmacol 526: 89-100 2005, 2005
Hrabovszky E, Halász J, Meelis W, Kruk MR, Liposits Zs, Haller J: Neurochemical characterization of hypothalamic neurons involved in attack behavior: glutamatergic dominance and co-expression of thyrotropin-releasing hormone in a subset, Neuroscience 133: 657-666, 2005, 2005
Mikics É, Barsy B, Barsvári B, Haller J: Behavioural specificity of non-genomic glucocorticoid effects: coping responses on the elevated plus-maze and the open-field, Horm. Behav. 48: 152-162, 2005, 2005
Haller J, Kruk MR.: Normal and abnormal aggression: human disorders and novel laboratory models, Neurosci Biobehav Rev 30: 292-303, 2006, 2006
Haller J, Tóth M, Halász J, de Boer SF: Patterns of violent aggression-induced brain cFos expression in male mice selected for aggressiveness., Physiol Behav 2006; 88: 173-182, 2006
Leveleki Cs., Sziray N, Levay G, Barsvári B, Soproni K, Mikics É, Haller J.: Pharmacological evaluation of the stress-induced social avoidance model of anxiety, Brain Res Bull 69: 153-160, 2006, 2006
Sziray N, Leveleki Cs, Levay G, Haller J.: Mechanisms underlying the long term behavioral effects of traumatic experience: the role of serotonin/noradrenaline balance and NMDA receptors., Brain Res Bull, 2007; 71: 376–385, 2007
Halász J, Tóth M, Mikics É, Hrabovszky E, Barsy B, Barsvári B, Haller J: The effect of NK1 receptor blockade on territorial aggression and in a model of violent aggression in rats, Biol. Psych. 2008; 63: 271-278., 2008
Haller J, Mikics E, Makara GB.: The effects of non-genomic glucocorticoid mechanisms on bodily functions and the central neural system. A critical evaluation of findings., Front Neuroendocrinol. 2007 Oct 24; [Epub ahead of print] PMID: 18054070, 2008




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